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Accuracy of urea breath test in Helicobacter pylori infection: Meta-analysis

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World Journal of Gastroenterology 2015年第4期21卷 1305-1314页

作者： Mazen Ferwana Imad Abdulmajeed Ali Alhajiahmed Wedad Madani Belal Firwana Rim Hasan Osama Altayar Paul J Limburg Mohammad Hassan Murad Bandar Knawy National and Gulf Center for Evidence-Based Health Practice King Saud Bin Abdulaziz University for Health SciencesRiyadh 11426Saudi Arabia Department of Medicine University of Missouri ColumbiaMissouriMO 65211United States Knowledge and Evaluation Research Unit Mayo ClinicRochesterMN 65212United States Knowledge and Evaluation Research Unit Mayo ClinicRochesterMN 55905United States Department of Internal Medicine Allegheny General HospitalPittsburgPA 55905United States Division of Gastroenterology Mayo ClinicRochesterMN 55905United States Division of Preventive Medicine Mayo ClinicRochesterMN 55905United States

AIM: To quantitatively summarize and appraise the available evidence of urea breath test(UBT) use to diagnose Helicobacter pylori(H. pylori) infection in patients with dyspepsia and provide pooled diagnostic accuracy ***: We searched MEDLINE, EMBASE, Cochrane library and other databases for studies addressing the value of UBT in the diagnosis of H. pylori infection. We included cross-sectional studies that evaluated the diagnostic accuracy of UBT in adult patients with dyspeptic symptoms. Risk of bias was assessed using QUADAS(Quality Assessment of Diagnostic Accuracy Studies)-2 tool. Diagnostic accuracy measures were pooled using the random-effects model. Subgroup analysis was conducted by UBT type(13C vs 14C) and by measurement technique(Infrared spectrometry vs Isotope Ratio Mass Spectrometry).RESULTS: Out of 1380 studies identified, only 23 met the eligibility criteria. Fourteen studies(61%) evaluated 13 C UBT and 9 studies(39%) evaluated 14 C UBT. There was significant variation in the type of reference standard tests used across *** sensitivity was 0.96(95%CI: 0.95-0.97) andpooled specificity was 0.93(95%CI: 0.91-0.94). Likelihood ratio for a positive test was 12 and for a negative test was 0.05 with an area under thecurve of 0.985. Meta-analyses were associated with a significant statistical heterogeneity that remained unexplained after subgroup analysis. The included studies had a moderate risk of ***: UBT has high diagnostic accuracy for detecting H. pylori infection in patients with dyspepsia. The reliability of diagnostic meta-analytic estimates however is limited by significant heterogeneity.

关键词： Helicobacter pylori dyspepsia Breath tests Urea/an

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Stomach and duodenum

外科研究与新技术 1992年第4期 215-217页

920683 The relationship between the fast-ing gastric bile acids and non-ulcer dyspep-sia. FENG Weihua(冯伟华), et al. Dept Bio-chemist, Changhai Hosp, 2nd Milit Med *** 200433 Chin. J Digest 1992; 12(2):77-79. In the ... 详细信息

关键词： fasting duodenum Digest chemist dyspepsia ConA motility pathogenesis membranous gastritis

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General Treatment

China Medical Abstracts(Internal Medicine) 2009年第1期26卷 6-7页

2009012 Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial. ZHU Liming(朱丽明), et al. Dept Gastroenterol, PUMC & CAMS, Beijing 100730. Chin J Intern Med 2008;47(11):910-913. Objective To investigate the efficacy and safety of compound azintamide on dyspepsia symptoms. Methods One hundred and eighty dyspepsia patients were divided into two

关键词： dyspepsia hundred CAMS 朱丽 discomfort satisfactory rally tablets

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*** TRACT

外科研究与新技术 1993年第4期 214-216页

*** and duodenum930685 Seroprevalence of Helicobacter pylori insome inhabitants of Beijing *** Qiboet al.1st Teach Hosp,Beijing Med Univ,Bei-jing,*** Med J 1993;15(4):*** the use of an enzyme-linked immunosorbentassay... 详细信息

关键词： duodenum weekly strie district dyspepsia irritable duodenal relapse 叶剑雄 gastrin

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GENERAL TREATMENT

China Medical Abstracts(Internal Medicine) 1995年第2期12卷 68-69页

Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group

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World Journal of Gastroenterology 2014年第46期20卷 17388-17398页

作者： Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos Department of Epidemiology Faculty of Public HealthUniversity of S?o PauloS?o Paulo 01246-904Brazil Janssen-Cilag Farmacêutica Ltda. S?o Paulo 05501-900Brazil Department of Gastroenterology Faculty of MedicineUniversity of S?o PauloS?o Paulo 05409-001Brazil

AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South ***:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey *** Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage *** were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal *** response data from each respondent were weighted by the numbers of adults and landline telephones in each *** analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census ***:Among 4570 households contacted,an adult from 3050(66.7%)agreed to *** nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)*** than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were *** than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per *** of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing *** instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdomi

关键词： dyspepsia Epidemiology Esophagus Gastroesophageal reflux Prevalence Stomach

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Stomach and duodenum

外科研究与新技术 1993年第1期 42-43页

930131 Measurement of gastric emptying innon-ulcer *** Xiaohua(侯晓华),et *** Gastroenterol,Union Hosp,TongjiMed Univ,Wuhan,*** J Intern Med1992;31(10):*** real-time ultrasonography,we moni-tored gastric emptying indirectly in 26 cases ofnon-ulcer dyspepsia(NUD)and 13 healthyadults by determing the anteroposterior gastricmeasurement of a single section of the stomachin the corpus fundus immediately after drinking500ml water and then every 10 *** *** average time for 50% gastric empty-ing in NUD patients(36.46±13.13,x±s)waslonger than that in healthy adults(23.54±5.93),but the half time of gastric emptying inChina Medical Abstracts(Internal Medicine)

关键词： emptying duodenum dyspepsia fundus Wuhan immediately drinking corpus indirectly minutes

Changes in patients' symptoms and gastric emptying after Helicobacter pylori treatment

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World Journal of Gastroenterology 2016年第18期22卷 4585-4593页

作者： Chun-Ling Zhang Chang-Hui Geng Zhi-Wei Yang Yan-Lin Li Li-Quan Tong Ping Gao Yue-Qiu Gao Department of Ultrasound Daqing Oilfield General Hospital Department of General Surgery the Fifth Affiliated Hospital of Harbin Medical University Department of Gastroenterology Daqing Oil Field General Hospital Department of Gastroenterology Harbin Medical University Affiliated Fifth Hospital

AIM: To investigate the changes in clinical symptoms and gastric emptying and their association in functional dyspepsia(FD) ***: Seventy FD patients were enrolled and divided into 2 groups Helicobacter pylori(H. pylori)-negative group(28 patients), and H. pylori-positive group(42 patients). Patients in the H. pylori-positive group were further randomly divided into groups: H. pylori-treatment group(21 patients) and conventional treatment group(21 patients). Seventy two healthy subjects were selected as the control group. The proximal and distal stomach area was measured by ultrasound immediately after patients took the test meal, and at 20, 40, 60 and 90 min; then, gastric half-emptying time was calculated. The incidence of symptoms and gastric half-emptying time between the FD and control groups were compared. The H. pylori-negative and conventional treatment groups were givenconventional treatment: domperidone 0.6 mg/(kg/d) for 1 mo. The H. pylori-treatment group was given H. pylori eradication treatment + conventional treatment: lansoprazole 30 mg once daily, clarithromycin 0.5 g twice daily and amoxicillin 1.0 g twice daily for 1 wk, then domperidone 0.6 mg/(kg/d) for 1 mo. The incidence of symptoms and gastric emptying were compared between the FD and control groups. The relationship between dyspeptic symptoms and gastric half-emptying time in the FD and control groups were analyzed. Then total symptom scores before and after treatment and gastric half-emptying time were compared among the 3 groups. RESULTS: The incidence of abdominal pain, epigastric burning sensation, abdominal distension, nausea, belching, and early satiety symptoms in the FD group were significantly higher than in the control group(50.0% vs 20.8%; 37.1% vs 12.5%; 78.6% vs 44.4%; 45.7% vs 22.2%; 52.9% vs 15.3%; 57.1% vs 19.4%; all P < 0.05). The gastric half-emptying times of the proximal end, distal end, and the whole stomach in the FD group were slower than in the control grou

关键词： Functional dyspepsia Gastric emptying Ultrasound

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Drug treatment

外科研究与新技术 1995年第2期 68-69页

950229 A controlled multi—center clinical trial oncisapride in treatment of functional ***(王宝恩),et *** Friendship Hosp,*** J Intern Med 1995;34(3):180—184.A controlled muhi-centre clinical trial was con-ducted for evaluating the efficacy and safety of cis-apride in the treatment of 414 cases of functional dys-pepsia with 169 cases as *** were

关键词： dyspepsia 王宝恩 morphine evaluating Drug treatment saline centre Ningbo nausea lamine