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Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression

Neural Regeneration Research 2022年第3期17卷 632-642页

作者： Ning-Xi Zeng Hui-Zhen Li Han-Zhang Wang Kai-Ge Liu Xia-Yu Gong Wu-Long Luo Can Yan Li-Li Wu Research Center for Basic Integrative Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina

Icariin(ICA) has a significant capacity to protect against depression and hippocampal injury,but it cannot effectively cross the bloodbrain barrier and accumulate in the ***,the mechanism by which ICA protects against hippocampal injury in depression remains *** this study,we performed proteomics analysis of cerebrospinal fluid to investigate the mechanism by which ICA prevents dysfunctional hippocampal neurogenesis in depression.A rat model of depression was established through exposure to chronic unpredictable mild stress for 6 weeks,after which 120 mg/kg ICA was administered subcutaneously every *** results showed that ICA alleviated depressive symptoms,learning and memory dysfunction,dysfunctional neurogenesis,and neuronal loss in the dentate gyrus of rats with *** stem cells from rat embryonic hippocampi were cultured in media containing 20% cerebrospinal fluid from each group of rats and then treated with 100 μM *** addition of cerebrospinal fluid from rats treated with ICA largely prevented the corticosterone-mediated inhibition of neuronal proliferation and ***-two differentially expressed proteins regulated by chronic unpredictable mild stress and ICA were identified through proteomics analysis of cerebrospinal *** proteins were mainly involved in the ribosome,PI3 K-Akt signaling,and interleukin-17 signaling *** reaction monitoring mass spectrometry showed that Rps4 x,Rps12,Rps14,Rps19,Hsp90 b1,and Hsp90 aa1 were up-regulated by chronic unpredictable mild stress and down-regulated by *** contrast,Htr A1 was down-regulated by chronic unpredictable mild stress and up-regulated by *** findings suggest that ICA can prevent depression and dysfunctional hippocampal neurogenesis through regulating the expression of certain proteins found in the cerebrospinal *** study was approved by the Experimental Animal Ethics Committee of Guangzhou University of Chinese

关键词： cerebrospinal fluid chronic unpredictable mild stress depression dysfunctional hippocampal neurogenesis hippocampus icariin proteomics ribosome pathway

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