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Effect of intra-arterial infusion with triolein emulsion on rabbit liver

World Journal of Gastroenterology 2014年第39期20卷 14442-14449页

作者： Yong-Woo Kim Young Mi Park Sik Yoon Hak Jin Kim Do Yoon Park Byung Mann Cho Seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Pusan National University College of Medicine Yangsan 626-770 South Korea Department of Radiology Busan Paik Hospital Inje University Pusan 614-735 South Korea Department of Anatomy Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Radiology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Pathology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Preventive Medicine Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Pusan National University Postgraduate School Pusan National University Pusan 602-739 South Korea

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit ***: An emulsion of 0.2 mL triolein in 20 mL of saline was infused into either the hepatic arteries of nine rabbits(group 1) or the superior mesenteric arteries of 12 rabbits(group 2). Five rabbits infused with 20 mL of normal saline were used as a control group(group 3). The serum aspartate aminotransferase(AST) and alanine aminotransferase(ALT) levels were measured to evaluate liver function in each group just before the infusion, at 2 h, day 1, day 4, and day 7 following infusion. Each rabbit in all of the groups was infused with Evans blue on day 7 to evaluate changes in vascular permeability, and obtain the stained area of the hepatic surface. If the stained area was not available, the anteroinferior portion of the right hepatic lobe was selected. The obtained tissues were examined by light, electron and confocal microscopy. The changes in AST and ALT levels at each time point were calculated and statistically analyzed using a mixed linear model. A P value 0.05). Only three rabbits in each group showed hepatic surface staining with the Evans blue dye. Light and electron microscopic findings showed no specific changes in the selected hepatic tissues. Confocal microscopic examination with transferase-mediated dUTP nick-end labeling stain revealed lack of hepatocyte ap

关键词： Triolein Emulsions Hepatology Liver dys-function H

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