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Traditional Chinese medicine during the COVID-19 pandemic:recent successes and future perspectives

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Acupuncture and Herbal Medicine 2023年第4期3卷 357-359页

作者： Xiaopeng Chen Mei Wang State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China Naturalis Biodiversity Center Darwinweg 22333 CR Leiden Postbus 95172300 RALeidenNetherlands SU BioMedicine BV Galileiweg 82333 BD LeidenNetherlands

The article titled“Three medicines and three formulas in COVID-19:from bench to bedside”introduces the clinical effects and mechanisms of three medicinal products and three prescription formulas(TMTF)from traditiona... 详细信息

关键词： COV during medicines

2006～2008年重庆大气降水δD和δ18 O特征初步分析

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水科学进展 2010年第6期21卷 757-764页

作者：李廷勇李红春沈川洲杨朝秀李俊云衣成城袁道先王建力谢世友 Ting-yong Hong-chun Chuan-zhou Chao-xiu Jun-yun Cheng-cheng Dao-xian Jian-li Shi-you 西南大学地理科学学院重庆400715 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室陕西西安710075 三峡库区生态环境教育部重点实验室(重庆大学&西南大学成功大学地球科学系台湾台南70101 台湾大学地质科学系台湾台北10617 西南大学地理科学学院重庆400715

大气降水稳定同位素组成受到温度、蒸发、水汽源地等多种因素的复杂影响,在不同时间和不同地区具有很大差异。通过分析2006~2008年间重庆雨水样品的δD和δ18O,初步建立了当地的大气降水线方程。当地的大气降水稳定同位素组成在不同季... 详细信息

大气降水稳定同位素组成受到温度、蒸发、水汽源地等多种因素的复杂影响,在不同时间和不同地区具有很大差异。通过分析2006~2008年间重庆雨水样品的δD和δ18O,初步建立了当地的大气降水线方程。当地的大气降水稳定同位素组成在不同季节变化明显:夏季降水中的稳定同位素值普遍偏轻,而冬季降水中稳定同位素值普遍偏重。水汽来源是控制当地大气降水稳定同位素组成的最重要原因,而蒸发作用等是控制短期次降水事件中雨水稳定同位素组成的重要影响因素。

关键词：重庆大气降水线特征分析 Study during 稳定同位素组成同位素值蒸发作用雨水影响因素夏季降水水汽源地水汽来源控制降水事件季节变化多种因素冬季降水水样品

Endocytosis and Vesicular Transport of Plasmid DNA in Cells during Electric Field-Mediated Gene Delivery

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医用生物力学 2019年第A01期34卷 12-13页

作者： Fan Yuan Department of Biomedical Engineering Duke University

Pulsed electric field has been used widely as a nonviral approach to improving gene delivery in basic and translational research[1-2].The technique has been called electrotransfection(ET),electroporation,electrogene transfer,and gene electroinjection in the literature [1,3].It has a great potential to improve clinical treatment of diseases through delivery of vaccines and therapeutic genes,genome and epigenome editing,and generation of human induced pluripotent stem cells for tissue engineering[1-3].during ET,extracellular transport of plasmid DNA(pDNA)relies on electrophoresis,which is critical for applications in vivo.However,mechanisms of intracellular transport remain to be understood.The lack of understanding has hindered the translation of ET technology to the clinic.It is well known that pulsed electric field can generate transient hydrophilic pores in the plasma membrane(i.e.,electroporation)that permit membrane-impermeant molecules to enter cells.Although the pores have yet to be visualized directly under a microscope,the electric field-induced membrane permeabilization has been demonstrated through experimental measurements of electrical conductance of synthetic lipid membranes and plasma membranes,direct observation of fluorescent markers crossing the membranes facing both cathode and anode,and numerical simulations of the membrane permeabilization[1,3].Results from the simulations have predicted that the cutoff size of the pores is on the order of a few hundred nanometers,and the lifetime of the pores that are larger than 100 nm is on the order of 10 msec.Although these data provide a solid evidence of the membrane permeabilization,recent studies have demonstrated that the generation of the pores is insufficient for ET[1,4].The reasons are as follows.First,the lifetime of the pores is several orders of magnitude shorter than the time scale for pDNA uptake,which is on the order of 10 min.Second,complex formation between pDNA and plasma membrane is a necessary condition for successful gene transfer.Thir

关键词： Endocytosis Vesicular Transport Plasmid DNA Cells during Electric Field-Mediated Gene Delivery DNA

Transcriptomic and epigenomic remodeling occurs during vascular cambium periodicity in Populus tomentosa

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Horticulture Research 2021年第1期8卷 1271-1286页

作者： Bo Chen Huimin Xu Yayu Guo Paul Grunhofer Lukas Schreiber Jinxing Lin Ruili Li Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083China College of Biological Sciences and Biotechnology Beijing Forestry UniversityBeijing 100083China Institute of Tree Development and Genome Editing Beijing Forestry UniversityBeijing 100083China College of Biological Sciences China Agricultural UniversityBeijing 100193China Institute of Cellular and Molecular Botany University of BonnKirschallee 1D-53115 BonnGermany

Trees in temperate regions exhibit evident seasonal patterns,which play vital roles in their growth and development.The activity of cambial stem cells is the basis for regulating the quantity and quality of wood,which has received considerable attention.However,the underlying mechanisms of these processes have not been fully elucidated.Here we performed a comprehensive analysis of morphological observations,transcriptome profiles,the DNA methylome,and miRNAs of the cambium in Populus tomentosa during the transition from dormancy to activation.Anatomical analysis showed that the active cambial zone exhibited a significant increase in the width and number of cell layers compared with those of the dormant and reactivating cambium.Furthermore,we found that differentially expressed genes associated with vascular development were mainly involved in plant hormone signal transduction,cell division and expansion,and cell wall biosynthesis.In addition,we identified 235 known miRNAs and 125 novel miRNAs.Differentially expressed miRNAs and target genes showed stronger negative correlations than other miRNA/target pairs.Moreover,global methylation and transcription analysis revealed that CG gene body methylation was positively correlated with gene expression,whereas CHG exhibited the opposite trend in the downstream region.Most importantly,we observed that the number of CHH differentially methylated region(DMR)changes was the greatest during cambium periodicity.Intriguingly,the genes with hypomethylated CHH DMRs in the promoter were involved in plant hormone signal transduction,phenylpropanoid biosynthesis,and plant–pathogen interactions during vascular cambium development.These findings improve our systems-level understanding of the epigenomic diversity that exists in the annual growth cycle of trees.

关键词： periodicity finding during

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洋务运动时期士向知识分子的初步转化

安徽师范大学学报（社会科学版） 2010年第6期38卷 719-723页

作者：章征科安徽师范大学政法学院安徽芜湖241003

洋务运动时期是传统中国士向知识分子转化的重要时期。这一时期已具备了士向知识分子转化的条件,中国政治、经济、文化各层面从思想到实践都出现了新的因素,士自身的许多新观念反映了这一时代的变化,表明他们之中不少人已开始转变为知... 详细信息

洋务运动时期是传统中国士向知识分子转化的重要时期。这一时期已具备了士向知识分子转化的条件,中国政治、经济、文化各层面从思想到实践都出现了新的因素,士自身的许多新观念反映了这一时代的变化,表明他们之中不少人已开始转变为知识分子。

关键词：洋务运动时期知识分子 Movement during Transformation 中国政治新观念文化条件思想实践时代经济

China's Economic Development and its Impact on the World during the Past 40-year Reform and Opening-up

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Peace 2018年第2期 8-13页

作者： Zhang Jianping Western Asian and African Studies the Research Institute of the Ministry of Commerce Shen Bo Economics College Peking University

The year 2018 coincides with the 40 th anniversary of China's reform and opening-up. Over the past 40 years, China's economic development has made great achievements, which may be regarded as a "miracle" of economic development. This economic miracle is reflected in the scale and quality of China's economic development. China's 4-decade economic development has not only brought great changes to Chinese society, but also has a profound impact on the growth and development of the world economy. However, this does not mean that China has found a complete new road to economic development. China needs to correctly view its achievements in the 40-year reform and opening-up, and accelerate the transformation and upgrading of economic development in a new era, so as to make a greater contribution to the sustainable development of the world economy.

关键词： China’s Economic Development and its Impact on the World during the Past 40-year Reform and Opening-up World

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主动深度介入:转型期教育实践研究的新方式

现代大学教育 2010年第6期26卷 38-43页

作者：伍红林江苏淮阴师范学院教科院

"主动深度介入"是当代中国社会转型期教育理论研究者开展教育实践研究的新方式。在秉持坚定的教育学立场,主张实践研究与实践变革过程相统一及根据研究与变革内在需要对各种研究方法进行具体综合运用,强调理论者与实践者、理论与实践、"... 详细信息

"主动深度介入"是当代中国社会转型期教育理论研究者开展教育实践研究的新方式。在秉持坚定的教育学立场,主张实践研究与实践变革过程相统一及根据研究与变革内在需要对各种研究方法进行具体综合运用,强调理论者与实践者、理论与实践、"事"与"人"三大关系的内在融通与交互生成等方面,它形成了自己的独特。但是,在具体的实施过程中,它亦有一定限制条件。

关键词：转型期教育实践研究新方式 Active during Practice Educational Research Approach 教育理论当代中国社会教育学立场综合运用研究方法限制条件实施过程三大关系内在需要内在融通交互生成

during the “Thirteenth Five Year Plan” Period, China will Drive Forward Five Major Reforms in Mineral Resource Management

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China Nonferrous Metals Monthly 2016年第7期 9-10页

‘The Outline of Land and Resource in the"Thirteenth Five Year Plan"’clearly pointed out that,in the"Thirteenth Five Year Plan"period,land and resource management will continue to adhere to dual emphasis on protection and guarantee,insist on cost saving and efficient utilization,it also identified the direction of speeding up mineral resource management system reform.

关键词： insist Forward adhere during the Period guarantee prospecting emphasis Major pointed

Morphological Evolution during Synthesis of New AlPO4·H2O Crystal

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Chinese Physics Letters 2005年第10期22卷 2704-2707页

作者：陈万春刘道丹王育人 Institute of Physics Chinese Academy of Sciences Beijing 100080 National Laboratory of Microgravity Institute of Mechanics Chinese Academy of Sciences Beijing 100080

A new crystal of aluminophosphate, AIPO4·H2O, is synthesized from two-batch aqueous solution under hydrothermal conditions. Three types of the crystal habits, i.e. the tetragonal double pyramid, the tetragonal prism and the plate-type tetragonal prism, are found from batch-A solution. Two types of the crystal habits, i.e. the hexagonal pyramid and the strip-type tetragonal prism, are found from batch-B solution. The change of crystal morphology is originated from the fluctuation of the synthesis conditions, such as the supersaturation, the temperature and the impurity content. It causes change of the step energies, the defect density and the step roughness, and further, change of the growth rates. Since the crystal morphology is sensitive to the mass transport mechanism, the crystal habits could be changed under the microgravity.

关键词： Morphological Evolution during Synthesis