检索结果-南通市图书馆

Life Metabolism 2022年第1期1卷 10-24页

作者： John R.Speakman Joel K.Elmquist Shenzhen Key Laboratory of Metabolic Health Center for Energy Metabolism and ReproductionShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina School of Biological Sciences University of AberdeenAberdeenUK State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental biologyChinese Academy of SciencesBeijingChina CAS Center of Excellence in Animal Evolution and Genetics KunmingChina Departments of Internal Medicine and Pharmacology Center for Hypothalamic ResearchUniversity of Texas SouthwesternDallasTXUSA

People completely lacking body fat(lipodystrophy/lipoatrophy)and those with severe obesity both show profound metabolic and other health issues.Regulating levels of body fat somewhere between these limits would,therefore,appear to be adaptive.Two different models might be contemplated.More traditional is a set point(SP)where the levels are regulated around a fixed level.Alternatively,dual-intervention point(DIP)is a system that tolerates fairly wide variation but is activated when critically high or low levels are breached.The DIP system seems to fit our experience much better than an SP,and models suggest that it is more likely to have evolved.A DIP system may have evolved because of two contrasting selection pressures.At the lower end,we may have been selected to avoid low levels of fat as a buffer against starvation,to avoid disease-induced anorexia,and to support reproduction.At the upper end,we may have been selected to avoid excess storage because of the elevated risks of predation.This upper limit of control seems to have malfunctioned because some of us deposit large fat stores,with important negative health effects.Why has evolution not protected us against this problem?One possibility is that the protective system slowly fell apart due to random mutations after we dramatically reduced the risk of being predated during our evolutionary history.By chance,it fell apart more in some people than others,and these people are now unable to effectively manage their weight in the face of the modern food glut.To understand the evolutionary context of obesity,it is important to separate the adaptive reason for storing some fat(i.***.the lower intervention point),from the nonadaptive reason for storing lots of fat(a broken upper intervention point).The DIP model has several consequences,showing how we understand the obesity problem and what happens when we attempt to treat it.

关键词： obesity BMI body fat adiposity evolution selection adaptive leptin resistance metabolic programming dual-intervention point model set-point model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：