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Specific sensing of antibiotics with metal-organic frameworks based dual sensor system

Nano Research 2022年第7期15卷 6430-6437页

作者： Yan-Long Zhao Qiang Chen Jie Lv Ming-Ming Xu Xin Zhang Jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering Faculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The illegal usage of antibiotics as veterinary drugs is an increasing threat for human *** specific sensing of antibiotics with different toxicity levels is of high challenge,and mainly relies on expensive,time-consuming,and complex *** realize specific sensing by rapid and handy optical sensors,a metal-organic framework(MOF)based dual sensor system is herein developed using two MOF materials BUT-128 and BUT-129 with high sensing selectivity and ***-128 and BUT-129 exhibit the lowest limit of detection(LOD)towards chloramphenicol and furazolidone among reported MOF *** corresponding dual sensor system with enriched signal readouts realized specific sensing of the strictly forbidden antibiotics(chloramphenicol and nitrofurans)from other regulated veterinary drugs including thiamphenicol,a structural analog of ***,the strategy of this work is expected to flourish the development of optical sensors with high specificity for environment and food safety purposes.

关键词： antibiotics specific sensing metal-organic frameworks dual sensor fluorescence quenching

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Assessment of Adaptive Rate Response Provided by Accelerometer, Minute Ventilation and dual sensor Compared with Normal Sinus Rhythm During Exercise： A Self-controlled Study in Chronotropically Competent Subjects

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Chinese Medical Journal 2015年第1期128卷 25-31页

作者： Yuanyuan Cao Yiqun Zhang Yangang Su Jin Bai Wei Wang Junbo Ge Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China Institute of Advancing Science Boston Scientific-China Shanghai 200032 China

Background：dual sensor （DS） for rate adaption was supposed to be more *** evaluate its superiority,the DS （accelerometer [ACC] and minute ventilation [MV]） and normal sinus rate response were compared in a self-controlled way during exercise treadmill testing.Methods：This self-controlled study was performed in atrioventricular block patients with normal sinus function who met the indications of pacemaker ***-one patients came to the 1-month follow-up *** performed a treadmill test 1-month post implant while programmed in DDDR and sensor passive *** these patients,sensor response factors were left at default settings （ACC =8,MV =3） and sensor indicated rates （SIRs） for DS,ACC and MV sensor were retrieved from the pacemaker memories,along with measured sinus node （SN） rates from the beginning to 1-minute after the end of the treadmill test,and compared among study *** measures analysis of variance and profile analysis,as well as variance analysis of randomized block designs,were used for statistical analysis.Results：Fifteen patients （15/2 l） were determined to be chronotropically *** mean differences between DS SIRs and intrinsic sinus rates during treadmill testing were smaller than those for ACC and MV sensor （mean difference between SIR and SN rate：ACC ***,MV ***,DS ***,respectively,34.84,17.60,16.15 beats/min）,though no sensors could mimic sinus rates under the default settings for sensor response factor （ACC *** P-adjusted 〈 0.001; MV *** P-adjusted =0.002; DS *** P-adjusted =0.005）.However,both in the range of 1st minute and first 3 minutes of exercise,only the DS SIR profile did not differ from sinus rates （P-adjusted =0.09,0.90,respectively）.Conclusions：The DS under default settings provides more physiological rate response during physical activity than the corresponding single sensors （ACC or MV sensor）.Further study is needed to determine if individual optimization would further

关键词： Accelerometer Adaptive Rate Pacing dual sensor Minute Ventilation

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