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*** nanoparticles as a new drug vector for glaucoma therapy

Annals of Eye Science 2018年第1期 488-488页

作者： Florence Masse Mathieu Ouellette Elodie Boisselier Department of Medicine UniversitéLavalQuebecQCCanada Département d'ophtalmologie Facultéde MédecineCUO-RechercheCentre de recherche du CHU de QuébecHôpital du St-SacrementQuebecQCCanada

Background:Glaucoma is an optical neuropathy affecting over 67 million people in the *** of current active molecules,as travoprost(hydrophobic)is limited when administered by ophthalmic ***,more than 99.9%is discarded due to multiple factors including lacrimal *** retention time of drugs at the cornea leads to their poor *** aim of the project is to develop a drug delivery system allowing the drug penetration through biological *** hypothesis is that a drug delivery system based on gold nanoparticles should enhance the efficiency of the *** main objective is to study the encapsulation ability of gold nanoparticles towards *** specific objectives are(I)the synthesis and characterizations of gold nanoparticles;(II)the establishment of the encapsulation protocol;(III)the method development of the separation of free and encapsulated drugs and;(IV)the quantification of the encapsulated ***:Gold nanoparticles were synthesized by a new method developed in our *** encapsulation protocol was settled using aqueous conditions at 37℃.The separation of free and encapsulated drugs was performed with magnetic *** quantification of the encapsulated drugs was then performed by high performance liquid chromatography and confirmed by UV-visible ***:Gold nanoparticles of 28±1 nm were synthesized and purified according to our new experimental *** encapsulation protocol lasts 5 days in the optimised *** separation method involving magnetic beads was optimized to get rid of non-specific *** travoprost was incubated with the nanoparticles until the reach of equilibrium in ***:We showed that active molecules used for glaucoma therapy,as travoprost,can be encapsulated in gold *** analysis will allow identifying the encapsulation properties of various gold nanoparticles,differing by their size,shape and chemical s

关键词： Gold nanoparticles drug vector glaucoma travoprost

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Advances in Mycobacterium siderophore-based drug discovery

引用

Acta Pharmaceutica Sinica B 2011年第1期1卷 8-13页

作者： Jun-li He Jian-ping Xien Institute of Modern Biopharmaceuticals Southwest UniversityChongqing 400715China

Tuberculosis remains a public health threat of global *** is a scarce resource indispensable to both host and pathogen during infection with Mycobacterium tuberculosis,the causative agent of *** are critical molecules for iron acquisition under iron-limiting conditions and,as a very efficient pathogen,*** has evolved elaborate siderophores knowledge of which is being intensively translated into clinical *** paper summarizes the structures,types and physiological functions of Mycobacterium siderophores with emphasis on siderophore-inspired design of drugs and drug delivery vehicles.

关键词： Tuberculosis Mycobacterium tuberculosis Siderophore drug vector drug design

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