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Calixarene-integrated nano-drug delivery system for tumortargeted delivery and tracking of anti-cancer drugsin vivo

Nano Research 2022年第8期15卷 7295-7303页

作者： Lina Xu Jingshan Chai Ying Wang Xinzhi Zhao Dong-Sheng Guo Linqi Shi Zhanzhan Zhang Yang Liu Key Laboratory of Functional Polymer Materials of Ministry of Education College of ChemistryNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Nano-drug delivery systems(nanoDDS)have been extensively investigated clinically to improve the therapeutic effect of anticancer ***,the complicated synthesis during the preparation as well as the potential drug leakage during transportation has greatly limited their general *** this work,a calixarene-integrated nanoDDS(CanD)that achieves tumor-targeted delivery and tracking of anti-cancer drugs in vivo is *** hypoxia-responsive calixarene(SAC4A)exhibits high binding affinity to a series of anti-cancer drugs and rhodamine B(RhB)under normoxic condition while decreasing the binding affinity under hypoxic condition,which leads to the drug release and fluorescence recovery ***,the hypoxia-responsiveness of SAC4A conveys CanD with tumor-targeting ability,resulting in the enrichment of the drug in tumors and enhancement in tumor suppression in ***,CanD could become a general platform allowing the delivery of a wide scope of anti-cancer drugs that have strong host-guest interaction with SAC4A.

关键词： drug delivery system calixarene host-guest interaction hypoxia-responsiveness drug tracking

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Revealing drug targets with multimodal bioorthogonal AMPD probes through visual metabolic labeling

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Chinese Chemical Letters 2024年第12期35卷 405-410页

作者： Fukui Shen Yuqing Zhang Guoqing Luan Kaixue Zhang Zhenzhen Wang Yunhao Luo Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300353China College of Life Sciences Nankai UniversityTianjin 300071China

Multimodal bioorthogonal small molecule probes play a pivotal role in drug-focused biomedical ***,existing drug tracking and imaging techniques face obstacles in living organisms,hindering precise drug localization and target protein ***,we introduced a multimodal probe named 1-(azidomethyl)pyrene-4,5–dione(AMPD).The probe incorporates adjacent dione structures at the pyrene *** selectively interacts with oxygen-rich alkene-labeled drug molecules under ice-blue LED light exposure,producing specific fluorescence emission and enabling in vivo tracking and flow cytometry sorting.A methyl azide group was also introduced at the pyrene core to help efficiently enrich target proteins via click chemistry with alkyne-functionalized *** demonstrates exceptional biocompatibility,rendering it highly suitable for visual photo-triggered tracking *** with metabolic labeling using an oxygen-rich alkene-tagged drug molecule probe,AMPD is effective for live animal,tissue,cellular,and in-gel imaging,as well as target protein identification through magnetic *** its versatile capabilities,AMPD enhances our comprehension of drug-target interactions at the in vivo level and expedites the process of drug discovery.

关键词： Multimodal bioorthogonal probe Bioorthogonal reactions Photoclick In-situ drug tracking

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