检索结果-南通市图书馆

Intensive care drug therapy and its potential adverse effects on blood pressure and heart rate in critically ill children

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第9期19卷 902-911页

作者： Lisa Marie Kiesel Astrid Bertsche Wieland Kiess Manuela Siekmeyer Thilo Bertsche Martina Patrizia Neininger drug Safety Center and Clinical Pharmacy Institute of PharmacyMedical FacultyLeipzig UniversityBruederstr.3204103 LeipzigGermany Division of Neuropediatrics University Hospital for Children and AdolescentsFleischmannstr.817475 GreifswaldGermany Department of Women and Child Health Hospital for Children and Adolescents and Center for Pediatric ResearchUniversity Hospital of LeipzigLiebigstr.20a04103 LeipzigGermany

Background Owing to complex treatment,critically ill children may experience alterations in their vital *** investigated whether such hemodynamic alterations were temporally and causally related to drug *** In a university pediatric intensive care unit,we retrospectively analyzed hemodynamic alterations defined as values exceeding the limits set for heart rate(HR)and blood pressure(BP).For causality assessment,we used the World Health Organization–Uppsala Monitoring Center(WHO–UMC)system,which categorizes the probability of causality as“certain,”“probable,”“possible,”and“unlikely.”Results Of 315 analyzed patients with 43,200 drug prescriptions,59.7%experienced at least one hemodynamic alteration;39.0%were affected by increased HR,19.0%by decreased HR,18.1%by increased BP,and 16.2%by decreased *** to drug information databases,83.9%of administered drugs potentially lead to hemodynamic ***,88.3%of the observed hemodynamic alterations had a temporal relation to the administration of drugs;in 80.2%,more than one drug was *** on the WHO–UMC system,a drug was rated as a“probable”causing factor for only 1.4%of hemodynamic *** the remaining alterations,the probability ratings were lower because of multiple potential causes,e.g.,several *** Critically ill children were frequently affected by hemodynamic *** administration of drugs with potentially adverse effects on hemodynamic parameters is often temporally related to hemodynamic *** alterations are often multifactorial,e.g.,due to administering multiple drugs in rapid succession;thus,the influence of individual drugs cannot easily be captured with the WHO–UMC system.

关键词： Adverse drug reaction drug therapy Hemodynamic monitoring Multifactorial causality Pediatric intensive care unit

drug therapy in patients with Parkinson’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2012年第1期1卷 68-80页

作者： Thomas Muller Department of Neurology St.Joseph Hospital Berlin-WeissenseeGartenstr.113088 BerlinGermany

Parkinson`s disease(PD)is a progressive,disabling neurodegenerative disorder with onset of motor and non-motor *** reduce quality of life of PD patients and cause caregiver *** review aims to provide a survey of possible therapeutic options for treatment of motor and non motor symptoms of PD and to discuss their relation to each ***-B-Inhibitors,NMDA antagonists,dopamine agonists and levodopa with its various application modes mainly improve the dopamine associated motor symptoms in *** armentarium of PD drugs only partially influences the onset and occurrence of non motor *** PD features predominantly result from non dopaminergic *** features,such as seborrhea,hyperhidrosis,orthostatic syndrome,salivation,bladder dysfunction,gastrointestinal disturbances,and neuropsychiatric symptoms,such as depression,sleep disorders,psychosis,cognitive dysfunction with impaired execution and impulse control may *** therapy of these non motor symptoms complicates long-term PD drug therapy due to possible occurrence of drug interactions,-side effects,and altered pharmacokinetic behaviour of applied *** substituting compounds themselves may contribute to onset of these non motor *** complicates the differentiation from the disease process itself and influences therapeutic options,which are often limited because of additional morbidity with necessary concomitant drug therapy.

关键词： Motor symptoms Parkinson’s disease non motor features drug therapy

Advances in drug therapy for Alzheimer’s Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2020年第6期40卷 999-1008页

作者： Chuan-cong ZHU Si-yu FU Yu-xin CHEN Ling LI Ruo-lin MAO Jian-zhi WANG Rong LIU Yi LIU Xiao-chuan WANG Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Department of Pathology and Pathophysiology School of MedicineJianghan UniversityWuhan 430056China

Alzheimer’s disease(AD)is a chronic neurodegenerative disease that mainly causes *** is a serious threat to the health of the global elderly *** money and effort has been invested in the development of drug therapy for AD *** drug therapies are currently under development or in clinical trials,based on two known mechanisms of AD,namely,Aβtoxicity and the abnormal Tau *** drugs are also being developed for other AD associated mechanisms such as neuroinflammation,neurotransmitter imbalance,oxidative damage and mitochondrial dysfunction,neuron loss and *** so,the number of drugs that can successfully improve symptoms or delay the progression of the disease remains very ***,multi-drug combinations may provide a new avenue for drug therapy for *** addition,early diagnosis of AD and timely initiation of treatment may allow drugs that act on the early pathological processes of AD to help improve the symptoms and prevent the progression of the condition.

关键词： Alzheimer’s disease Aβ tau drug therapy

Severe acute respiratory syndrome-coronavirus-2(SARS-COV-2)infection of pneumocytes with vaccination and drug therapy:Mathematical analysis and optimal control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2024年第2期17卷 299-334页

作者： R.Viriyapong P.Inkhao Department of Mathematics Faculty of Science Naresuan University Phitsanulok65000Thailand

We propose a mathematical model studying a within-host infection dynamics of SARSCoV-2 in *** model incorporates immune response,vaccination and antiviral *** crucial properties of the model-the existence,positivity and boundary of solutions are *** points and the basic reproduction number are *** stability of each equilibrium point is *** control is applied to the model by adding three control variables:vaccination,treatment by Favipiravir and treatment by *** results show that each individual control could reduce SARS-CoV-2 infection in some aspects;however,with a combination of three controls,we obtain the best results in reducing SARS-CoV-2 *** study has emphasized the importance of prevention by vaccine and the antiviral treatments.

关键词： SARS-CoV-2 vaccination drug therapy immune response optimal control

Endovascular treatment vs drug therapy alone in patients with mild ischemic stroke and large infarct cores

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第28期10卷 10077-10084页

作者： Wen-Hui Kou Xiao-Qin Wang Jin-Shui Yang Nan Qiao Xiao-Hui Nie Ai-Mei Yu Ai-Xia Song Qian Xue Department of Neurology First Affiliated Hospital of Hebei North UniversityZhangjiakou 075061Hebei ProvinceChina

BACKGROUND Treatment decision making is strictly associated with the outcomes in patients with ischemic stroke who show a large core *** care alone may result in suboptimal treatment efficacy,and endovascular treatment may be accompanied by safety *** endovascular treatment is superior to medical care is not well investigated in the clinical *** To investigate the efficacy of endovascular treatment and drug therapy alone in mild ischemic stroke patients with large infarct *** Fifty patients with mild ischemic stroke and 50 patients with acute ischemic stroke caused by anterior large vessel occlusion were selected at the First Affiliated Hospital of Hebei North University between January 2021 and December *** were divided into an endovascular therapy group and a drug therapy group according to different treatment *** the endovascular therapy group,there were 28 patients with minor stroke and 22 patients with large infarct *** drug therapy group had 22 patients with minor stroke and 28 patients with large infarct *** National Institutes of Health Stroke Scale(NIHSS) scores were collected and compared between the two groups immediately after the operation and 24 h and 7 d after the *** modified Rankin scale(m RS) and/or activity of daily living were assessed at hospital *** There was no significant difference in NIHSS scores between the two groups before the operation(P > 0.05).NIHSS scores were lower in the endovascular therapy group than in the drug therapy group at 24 h and 7 d after the operation and at hospital discharge(all P therapy group than in the drug therapy group(P drug therapy group,and the activity of daily living score was better in the endovascular treatment gr

关键词： Ischemic stroke Large infarct cores Endovascular therapy drug therapy Efficacy

Current status of drug therapy for alveolar echinococcosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第11期16卷 1243-1254页

作者： Qin-Dong Jing Ji-De A Lin-Xun Liu Hai-Ning Fan Department of General Surgery Qinghai Provincial People’s HospitalXining 810000Qinghai ProvinceChina School of Clinical Medicine Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Hepatic Hydatidosis Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Qinghai Province Research Key Laboratory for EchinococcosisAffiliated Hospital of Qinghai UniversityXining 810001Qinghai ProvinceChina

Alveolar echinococcosis(AE)is a chronic zoonotic parasitic disease caused by infection with Echinococcus *** is associated with a high mortality rate and poses a significant threat to human *** primary treatment for AE is surgical resection of the lesions;however,owing to its long incubation period and insidious disease progression,many patients are diagnosed only after the onset of complications such as liver cirrhosis,jaundice,and portal hypertension,which preclude curative surgical *** patients who are unwilling or unable to undergo surgery,lifelong administration of anti-AE medications is *** compounds,such as albendazole and mebendazole,are the current mainstays of treatment,offering good ***,these medications primarily inhibit parasite proliferation rather than eradicate the infection,and their long-term use can lead to significant drug-related toxic ***,there is an urgent need to develop new therapeutic strategies that convey better efficacy and reduce the adverse effects associated with current *** advancements in AE therapy include novel synthetic compounds such as antiviral agents,antibiotics,antineoplastic agents,immunosuppressants,and antiangiogenic agents,as well as natural compounds derived from traditional Chinese and Tibetan *** new drugs show promising clinical potential because they interfere with parasitic metabolic pathways and cellular *** review aims to discuss recent research on AE drug therapy,including mechanisms of action,dosing regimens,signalling pathways,and therapeutic outcomes,with a goal of providing new insights and directions for the development of anti-AE drugs and summarizing current advancements in AE pharmacotherapy.

关键词： Alveolar echinococcosis drug therapy Albendazole Synthetic compounds Natural compounds

New Developments in drug therapy and Research of Cerebral Vasospasm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Neurosurgery 2013年第4期3卷 72-93页

作者： Eleftherios Archavlis Peter Ulrich Mario Carvi YNievas Department of Neurosurgery Sana Klinikum OffenbachAkademisches Lehrkrankenhaus der UniversitatFrankfurtGermany Department of Neurosurgery Klinikum TraunsteinAkademisches Lehrkrankenhaus der UniversitatMünchenGermany

In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vaso-spasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Current research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.

关键词： Cerebral Vasospasm drug therapy Subarachnoid Hemorrhage Delayed Cerebral Ischemia New Developments Treatment

Research Progress of drug therapy for Diabetes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expert Review of Chinese Medical

Expert Review of Chinese Medical 2024年第1期2卷 6-9页

作者： Yuhang Li Chunhui Zhang Hui Gao Yunnan University of Economics and Management School of Medicine

Diabetes is mainly a series of symptoms of glucose metabolism disorder caused by relative or absolute insufficiencies of *** patients are accompanied by protein,fat,water and electrolyte disorders,including diabetes type 1 and diabetes type 2,of which diabetes type 2 accounts for more than 90%.The incidence rate of diabetes is high,the course of disease is long,and it is difficult to *** patients need long-term *** study analyzed the clinical manifestations and predisposing factors of diabetes,and explored the progress of drug treatment of diabetes,which is summarized as follows.

关键词： diabetes drug therapy research progress

Exploration for drug therapy in endometrial carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 1996年第5期109卷 360-360页

作者： X Zhang B Cao Obstetrics and Gynecology Hospital Shanghai Medical University.

OBJECTIVE To explore the therapeutic effect of three drugs, i.e., hydroxyprogesterone caproate (HPC), Tamoxifen (TMX) and Aminoglutethimide (AG), in the treatment of endometrial *** The patients were collected by double-blind method and classified into 6 groups (3 groups used single drug and 3 groups used combined drugs) at random. The patient was given assigned drug therapy for 10 days according to her group after being admitted to the hospital. Operations were performed 7-10 days after drug therapy. Plasma FSH, LH, E2 and P were measured by standard radioimmunoassay of WHO. ER and PR in cancer tissues were examined by enzyme linked histochemistry. Cancer tissues obtained before and after drug therapy were examined *** The values of FSH, LH and E2 decreased and that of P increased after single drug therapy in the group treated with HPC; and the values of FSH, LH, E2 and P all decreased in the groups treated with TMX and AG respectively (Pdrugs. The changes of FSH and E2 are remarkable (P0.05). PR and ER usually increased after treatment with TMX, but decreased with HPC or AG, or combined drugs. The pathological changes indicate that the tumors responded to all of the three drugs. The response to TMX was most significant, following which was *** HPC and TMX are two drugs proved to be useful in endometrial carcinoma. AG also can be used to treat endometrial carcinoma. It adds a new drug to the drug therapy for endometrial carcinoma.

关键词： High Performance Computing Exploration Pharmaceutical Preparations Double-Blind Method Silver TMX1 gene Endometrial Carcinoma drug therapy