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Resorcinarene-centered Amphiphilic Star-block Copolymers: Synthesis, Micellization and Controlled drug Release

Chinese Journal of Polymer Science 2014年第11期32卷 1431-1441页

作者： Chen Gao Ying Wang Wei-pu Zhu 沈之荃 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

Eight-arm star-shaped poly（■-caprolactone）-block-poly（ethylene glycol）s（SPCL-b-PEG） have been prepared by a combination of controlled ring-opening polymerization（CROP） and coupling reaction. First, eight-arm star-shaped poly（■-caprolactone）s（SPCL） with a resorcinarene core were synthesized using octamethyl tetraundecylresorcinarene octaacetate as octa-initiator and yttrium tris（2,6-di-tert-butyl-4-methylphenolate） [Y（DBMP）3] as catalyst. Then the coupling reaction was carried out between SPCLs and carboxyl-terminated methoxy poly（ethylene glycol）s（mP EG-COOH） in the presence of N,N′-dicyclohexylcarbodiimide（DCC） and 4-dimethylaminopyridine（DMAP）, resulting in eight-arm star-shaped SPCL-b-PEGs with controlled molecular weight and well-defined architecture. Furthermore, these amphiphilic eight-arm SPCL-b-PEGs could self-assemble into micelles with low critical micellar concentrations（CMC）, which was characterized by fluorescent spectroscopy. Moreover, indomethacin loaded micelles with high drug loading content and high encapsulation efficiency can be prepared, which is probably due to the highly branched architecture. The morphologies of micelles were characterized by transmission electron microscopy（TEM）, which exhibited diverse nanostructures as the drug loading contents varied. In vitro drug release of indomethacin from SPCL-b-PEG micelles was carried out in PBS, from which a sustained release behavior was observed. SPCL-b-PEG micelles did not show significant cytotoxicity at copolymer concentrations up to 1000 mg/L, making them very promising for drug delivery.

关键词： Star block copolymer Resorcinarene Micelles drug delivery.

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ELECTROSPINNING OF CYCLODEXTRIN FUNCTIONALIZED CHITOSAN/PVA NANOFIBERS AS A drug delivery.SYSTEM

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Chinese Journal of Polymer Science 2013年第10期31卷 1343-1351页

作者： Maryam Bazhban Mahdi Nouri Javad Mokhtari Department of Textile Engineering Faculty of Engineering University of Guilan

A new type ofnanofibrous structure from chitosan bearing carboxymethyl-β-cyclodextrin （CS-g-β-CD） as a novel drug delivery.system was synthesized by grafting carboxymethyl-β-cyclodextrin （CM β-CD） onto chitosan （CS） in the presence of water soluble 1-ethyl-3-（3-dimethylaminopropyl） carbodiimide （EDC） as the condensing agent and N-hydroxysuccinimide （NHS）. Defect free mats containing CS-g-β-CD have been fabricated using electrospirming of an aqueous solution of poly（vinyl alcohol）（PVA）/CS-g-β-CD blends. The morphology and diameter of the electrospun nanofibers were examined by scanning electron microscopy （SEM）. The average fiber diameter was in the range of 130-210 run. SEM images showed that the morphology and diameter of the nanofibers were mainly affected by weight ratio of the blend at constant applied voltage. The results revealed that increasing CS-g-β-CD content in the blends decreases the average fiber diameter. It was observed that the PVA/CS-g-β-CD nanofibrous mat provided a slower release of the entrapped drug in compare to PVA/CS nanofibrous mat.

关键词： Chitosan βcyclodextrin Nanofibers drug delivery.

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SYNTHESIS,CHARACTERIZATION AND NANOPARTICLE FORMATION OF STAR-SHAPED POLY(L-LACTIDE)WITH SIX ARMS

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Chinese Journal of Polymer Science 2008年第2期26卷 161-169页

作者：董常明 Department of Polymer Science & Engineering School of Chemistry and Chemical TechnologyShanghai Jiao Tong University

Well-defined star-shaped poly(L-lactide)with six arms(sPLLA)was synthesized via the ring-opening polymerization of L-lactide using dipentaerythritol as initiator and stannous octoate as catalyst in bulk at 125~*** effects of molar ratios of both monomer to initiator and monomer to catalyst on the molecular weights of as-synthesized sPLLA polymers were in detail *** molecular weights of sPLLA polymers linearly increased with the molar ratio of monomer to initiator,and the molecular weight dist...

关键词： Star-shaped poly(L-Lactide) Ring-opening polymerization Nanoparticles drug delivery.

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Fluid-Solid Interaction Analysis of drug delivery.Mechanism to Damaged Cancer Cellules in the Shape of Single-Walled Carbon Nanocone by Molecular Mechanics Approach

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Journal of Pharmacy and Pharmacology 2016年第2期4卷 73-87页

作者： Morteza Rasouli Gandomani Hassan Haddadpour College of Aerospace Engineering Sharif University of Technology Tehran 11155-8639 Tehran Iran

drug delivery.systems able to deliver the required dose of the drug to the target level use active or passive nano metric designed systems. In the earlier researches, carbon nanocones are used for transferring the serum to damaged proteins and damaged cancer cellules. In this lecture, stability analysis of drug delivery.to damaged cancer cellutes is studied in the shape of single-walled carbon nanocone. In this method, each atom is considered as node and interactions between them are supposed as 3D-beam elements. By supposing that potential energy in macro relations is equal to the nano relations, nano-drug characteristics can be calculated. Then shape functions can be extracted to use in blood＇s FEM model and using reduced-order method, divergence velocities of carbon nanocone can be found. In this lecture, carbon nanocones are modeled with different dimensions and boundary conditions and stability of them in blood flow is studied and optimized carbon nanocone is selected in blood flow. Results show that conical nano-drug structures have more efficiency in blood flow rather than tube nano-drug structures and by increasing length of carbon nanocones, dimensionless stability parameter decreased and by increasing declination angle of carbon nanocones, dimensionless stability parameter increased.

关键词： Conical Nano-drugs molecular mechanics drug delivery.

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Metal-Organic Frameworks for Energy, Environmental and Pharmaceutical Applications: A Computational Perspective

Metal-Organic Frameworks for Energy, Environmental and Pharm...

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The 1st International Congress on Advanced Materials 2011

作者： Jianwen Jiang Department of Chemical and Biomolecular Engineering National University of Singapore

Metal-organic frameworks (MOFs) have emerged as a new class of hybrid nanoporous materials. Composed of metal-oxide clusters and organic linkers, MOFs possess extremely large surface area (up to 6000 m 2 /g) and high porosity (up to 90%) ever recorded for crystalline materials. The judicious choice of controllable organic linkers and the variation of metal oxides allow the pore sizes, volumes and functionalities of MOFs to be tailed in a rational way for designable architectures. MOFs provide a wealth of opportunities for engineering new functional materials and are considered as versatile candidates for storage, separation, sensing, catalysis, and other important applications. An overview will be presented for the recent state-of-the-art computational studies on energy, environmental and pharmaceutical applications of MOFs. A few typical examples will be given: (1) CO 2 storage is examined in a series of MOFs by varying metal center, organic linker, functional group and framework topology. The affinity with CO 2 is enhanced by the addition of functional groups and the formation of constricted pores;both lead to a stronger adsorption at low pressures. The organic linker plays a critical role in tuning the free volume and accessible surface area, and thus largely determines CO 2 adsorption at high pressures. The capacities at high pressures correlate well with framework density, free volume, porosity and accessible surface area of MOFs. These molecular-based structure-function correlations are useful for a priori prediction of CO 2 capacity and for rational screening of MOFs toward the high-efficacy CO 2 storage. (2) The separation of CO 2 /CH 4 mixture is studied in MOFs with unique characteristics such as exposed metals, catenation and extra-framework ions. The catenated MOFs have a higher selectivity than their non-catenated counterparts. CO 2 /CH 4 selectivity in charged MOF is substantially higher than in neutral MOFs, and the highest among various MOFs reported

关键词： Metal-Organic Frameworks CO2 Storage and Capture drug delivery.

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Poly(Vinyl Alcohol)(PVAl)and Poly(N-2-Vinyl-Pyrrolidone)Hydrogels Nanostructured by Laponite Clay for drug delivery

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材料科学与工程（中英文B版） 2022年第3期12卷 97-107页

作者： Maria José.A.Oliveira Vinicius J.Santos Lucas Freitas de Freitas Ademar B.Lugão Duclerc F.Parra Nuclear and Energy Research Institute-IPEN-CNEN/SP.Av.Professor Lineu Prestes 2242Cidade UniversitáriaSão Paulo 05508-000SPBrazil

Hydrogels for wound dressings are usually developed for contact surfaces where mechanical properties are conveniently *** this sense nanocomposite hydrogels based on PVAl(poly(vinyl alcohol))and PVP(poly(N-2-vinil-pirrolidone))containing 0.5-1.5 wt%of the synthetic laponite RD clay were prepared by a gamma radiation process and compared with similar membranes composed separately of PVP or *** study aimed to evaluate the effect of clay on the properties and the differences of the polymer blend instead of a unique *** morphology of the hydrogels was evaluated by spectrometric techniques using XRD(X-ray diffraction),SEM(scanning electron microscopy),swelling assay,and FTIR(infrared spectroscopy).The swelling kinetics at 22℃and the mechanical properties by a tensile test comprised the structural properties that were *** results showed PVA/PVP network depends directly on the clay concentration in the nanocomposite *** blend PVP/PVAl proved to have potentially efficient mechanical properties for drug delivery.in the treatment of wounds.

关键词： Hydrogels clay nanocomposite drug delivery.

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