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Inhalable microparticles as drug delivery systems to the lungs in a dry powder formulations

Regenerative Biomaterials 2023年第1期10卷 218-248页

作者： Karolina Knap Konrad Kwiecien Katarzyna Reczynska-Kolman Elzbieta Pamuła Department of Biomaterials and Composites Faculty of Materials Science and CeramicsAGH University of Science and Technology30-059 KrakowPoland

Inhalation-administrated drugs remain an interesting possibility of addressing pulmonary *** drug delivery to the lungs allows one to obtain high concentration in the site of action with limited systemic distribution,leading to a more effective therapy with reduced required doses and side *** the other hand,there are several difficulties in obtaining a formulation that would meet all the criteria related to physicochemical,aerodynamic and biological properties,which is the reason why only very few of the investigated systems can reach the clinical trial phase and proceed to everyday use as a ***,we focused on powders consisting of polysaccharides,lipids,proteins or natural and synthetic polymers in the form of microparticles that are delivered by inhalation to the lungs as drug *** summarized the most common trends in research today to provide the best dry powders in the right fraction for inhalation that would be able to release the drug before being removed by natural *** review article addresses the most common manufacturing methods with novel modifications,pros and cons of different materials,drug loading capacities with release profiles,and biological properties such as cytocompatibility,bactericidal or anticancer properties.

关键词： pulmonary therapies drug delivery systems to lungs microparticles inhalers dry powder inhalers

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Electroconductivity,a regenerative engineering approach to reverse rotator cuff muscle degeneration

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Regenerative Biomaterials 2023年第1期10卷 1693-1712页

作者： Nikoo Saveh-Shemshaki Mohammed A.Barajaa Takayoshi Otsuka Elnaz S.Mirdamadi Lakshmi S.Nair Cato T.Laurencin The Cato T.Laurencin Institute for Regenerative Engineering University of ConnecticutFarmingtonCT 06030USA Department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA Department of Biomedical Engineering Imam Abdulrahman Bin Faisal UniversityDammam 31451Saudi Arabia Department of Orthopedic Surgery University of Connecticut Health CenterFarmingtonCT 06030USA Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA Department of Chemical&Biomolecular Engineering University of ConnecticutStorrsCT 06269USA

关键词： pulmonary therapies drug delivery systems to lungs microparticles inhalers dry powder inhalers

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