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double-edged effects caused by magnesium ions and alkaline environment regulate bioactivities of magnesium-incorporated silicocarnotite in vitro

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Regenerative Biomaterials 2021年第6期8卷 1-14页

作者： Qiang Wu Shunxiang Xu Fei Wang Bo He Xin Wang Ye Sun Congqin Ning Kerong Dai Shanghai Key Laboratory of Orthopedic Implant Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639Zhizaoju RoadShanghaiHuangpu District 200011China The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Normal UniversityNo.100Guilin RoadShanghaiXuhui District 200234China Department of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityNo.169East Lake RoadWuchang DistrictWuhan 430071China Department of Orthopaedics The First Affiliated Hospital of Nanjing Medical UniversityNo.300Guangzhou RoadDrum-tower DistrictNanjing210029China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesNo.1295Dingxi RoadChangning DistrictShanghai 200050China

Magnesium(Mg)is an important element for its enhanced osteogenic and angiogenic properties in vitro and in vivo,however,the inherent alkalinity is the adverse factor that needs further *** order to study the role of alkalinity in regulating osteogenesis and angiogenesis in vitro,magnesium-silicocarnotite[Mg-Ca5(PO4)2SiO4,Mg-CPS]was designed and *** this study,Mg-CPS showed better osteogenic and angiogenic properties than CPS within 10wt.%magnesium oxide(MgO),since the adversity of alkaline condition was covered by the benefits of improved Mg ion concentrations through activating Smad2/3-Runx2 signaling pathway in MC3T3-E1 cells and PI3K-AKT signaling pathway in human umbilical vein endothelial cells in ***,provided that MgO was incorporated with 15wt.%in CPS,the bioactivities had declined due to the environment consisting of higher-concentrated Mg ions,stronger alkalinity and lower Ca/P/Si ions *** to the results,it indicated that bioactivities of Mg-CPS in vitro were regulated by the double-edged effects,which were the consequence of Mg ions and alkaline environment ***,if MgO is properly incorporated in CPS,the improved bioactivities could cover alkaline adversity,making Mg-CPS bioceramics promising in orthopedic clinical application for its enhancement of osteogenesis and angiogenesis in vitro.

关键词： silicocarnotite magnesium double-edged effects osteogenesis and angiogenesis

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