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Preclinical study of a self-expanding pulmonary valve for the treatment of pulmonary valve disease

Regenerative Biomaterials 2020年第6期7卷 609-618页

作者： Dajun Kuang Yang Lei Li Yang Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityNo 29 Wangjiang RoadChengdu 610064China Venus Medtech(Hangzhou)Inc. 88 Jiangling RoadHangzhou 311053China

In the past decade,balloon-expandable percutaneous pulmonary valves have been developed and applied in clinical ***,all the existing products of pulmonary artery interventional valves in the market have a straight structure design,and they require a preset support frame and balloon *** shape design of the valve limits the application *** addition,the age of the population with pulmonary artery disease is generally low,and the existing products cannot meet the needs of anti-calcification properties and valve material *** this study,through optimization of the support frame and leaflet design,a self-expanding pulmonary valve product with a double bell-shaped frame was designed to improve the match of the valve and the implantation site.A loading and deployment study showed that the biomaterial of the valve was not damaged after being *** flow and fatigue in vitro tests showed that the fabricated pulmonary valve met the hydrodynamic requirements after 2108 accelerated fatigue *** safety and efficacy of the pulmonary valve product were demonstrated in studies of pulmonary valve implantation in 11 *** and echocardiography showed that the pulmonary valves were implanted in a good position,and they had normal closure and acceptable valvular *** 180 days’implantation results showed that the calcium content was 0.31-1.39 mg/g in the anti-calcification treatment group,which was significantly lower than that in the control valve without anti-calcification treatment(16.69 mg/g).Our new interventional pulmonary valve product was ready for clinical trials and product registration.

关键词： pulmonary valve self-expanding double bell-shaped anti-calcification preclinical

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