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Chromosomal Alterations in Patients with Alzheimer Disease in Manaus,Amazonas,Brazil

Journal of Pharmacy and Pharmacology 2019年第8期7卷 451-458页

作者： Cleiton Fantin Kledson Moraes Nunes Ernanda Raquel de Queirós Goncalves de Sousa e Fernandes Diana Vieira Brito Natalia Dayane Moura Carvalho Denise Corrêa Benzaquem Laboratório de Citogenética Escola Superior de Ciências da SaúdeUniversidade do Estado do AmazonasManausAmazonas 69065-001Brazil Laboratório de Análises Clínicas do Hospital Universitário Getúlio Vargas–HUGV ManausAmazonas 69020-170Brasil Secretaria Municipal de Saúde SEMSAManausAmazonas 69057-000Brasil

Alzheimer disease(AD)is a complex neurodegenerative pathology that is characterized by a cognitive *** causes and mechanisms are still largely *** has been suggested that both genetic and life exposure factors can contribute to AD *** are also evidences that chromosomal alterations can be related to this *** far,there is not a precise diagnosis for AD,which is given only after the exclusion of other dementia by clinical and neurological *** possible association of AD with chromosomal alterations and the easy access of classical cytogenetics analysis are important aspects to consider,given the difficulties in *** to the lack of similar studies in Brazil and the increasing number of AD cases in the state of Amazonas,the aim of this study was to investigate the presence of chromosomal alterations in patients diagnosed with AD in Manaus,Amazonas,*** blood lymphocytes of twelve patients and twelve healthy individuals with the same age were analyzed using conventional *** AD patients presented cells with autosomal aneuploidy,while no chromosomal alterations were found in the age-matched ***,rare events of double and multiple aneuploidies are being reported in association with AD for the first *** results corroborate that the increase in the frequencies of aneuploidies is not related to the aging process itself,but it might be associated to the disease ***,no chromosomes were preferentially affected in all AD patients,and no consistent karyotype pattern for AD lymphocytes was ***,our results do not support the use of standard cytogenetics as a tool for AD *** studies are necessary to understand better the association between chromosomal alterations and AD.

关键词： AD karyotyping numeric chromosomal alterations double aneuploidies multiple aneuploidies

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