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New Octadecanoyl diterpenoid Arabinoside from Conyza blinii

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Chemical Research in Chinese Universities 2009年第4期25卷 458-460页

作者： CHEN Lei SU Yan-fang TU Guang-zhong School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R China Beijing Institute of Microehemistry Beijing 100091 P. R. China

A new octadecanoyl diterpenoid glycoside,（E）-8α,15-dihydroxy-15-（3S-hydroxy-octadecanoyl）-13-labdene-8-O-α-L-arabinopyranoside（1）,was isolated from the aerial parts of Conyza blinii,and the structure was ident... 详细信息

关键词： Conyza blinii diterpenoid Labdane Arabinoside

Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways

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World Journal of Gastroenterology 2013年第31期19卷 5085-5093页

作者： Xuan Huang Bin Lv Shuo Zhang Qun Dai Bing-Bing Chen Li-Na Meng Department of Gastroenterology the First Affiliated Hospital Zhejiang Chinese Medical University

AIM:To study effect of diterpenoid C extracted from radix curcumae on Helicobacter pylori(***)-infected inflammation,intestinal metaplasia,and nuclear factor kappa B(NF-κB)signaling pathway in ***:We used I-type *** to infect human gastric epithelial gastric epithelium cell line(GES-1)cell lines,and then ***-infected GES-1 cells were treated with radix curcumae(RC)-derived diterpenoid C of different concentrations(5,10,20μg/mL)and *** expression of p65,IκB kinase(IKK)αand IKKγproteins was detected with Western blotting,and the expression of interleukin(IL)-8,IL-6 and IL-4 was determined with enzyme-linked immunosorbent assay *** were analyzed using SPSS software *** comparisons between groups of more than two unpaired values,one-way analysis of variance(ANOVA)was *** an ANOVA F value was significant,post hoc comparisons were performed between *** results were not normally distributed,the Mann-Whitney U test was used to compare two groups of unpaired values,whereas for comparisons between groups of more than two unpaired values,the Kruskal-Wallis H test was *** significance was established at Pditerpenoid C and amoxicillin all were 5μg/mL for gastric GES-1 *** expression of IL-8 was significantly increased,especially at 12 h time point;and the expression of IL-4 was decreased in *** GES-1 *** ***-infected GES-1 cells were treated with RC-derived diterpenoid C of different concentrations and amoxicillin,the expression of IL-8was decreased at 12,24,48,72 h points(Pditerpenoid C(20μg/mL)group;and the expression of IL-4 was increased,especially in moderate and high-concentration diterpenoid C(10 and 20μg/mL)***-derived diterpenoid C had the inhibitory effects on ***-induced p65 translocation from cytopla

关键词： Radix curcumae-derived diterpenoid C Helicobacter pylori Nuclear factor-κB Inflammatory cytokine

A new diterpenoid from the stem bark of Populus davidiana

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Chinese Chemical Letters 2008年第9期19卷 1080-1082页

作者： Xin Feng Zhang Xiang Li Byung Sun Min Ki Hwan Bae College of Forestry and Biotechnology Zhejiang Forestry University Hangzhou 311300 China Saskatoon Research Center Agriculture and Agri-Food Canada 107 Science Place SK Canada STN OX2 College of Pharmacy Catholic University ofDaegu Gyeongbuk 712-702 Republic of Korea College of Pharmacy Chungnam National University Daejeon 305-764 Republic of Korea

A new diterpenoid, named populusol A （1）, was isolated from the methanolic extraction of the stem bark of Populus davidiana. The structure was elucidated on the basis of extensive 1D and 2D NMR as well as HRFAB-MS s... 详细信息

关键词： Populus davidiana diterpenoid Populusol A

A new ent-abietane diterpenoid from Isodon macrophyllus

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Chinese Chemical Letters 2008年第7期19卷 849-851页

作者： Zheng Yue Chen Pei Yong Qiu Yong Xue Wang Su Ping Bai Fu Lin Yan Ji Xia Zhang Han Dong Sun Pharmaceutical Laboratory Xinxiang Medical University Xinxiang 453003 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A new ent-abietane diterpenoid, named dayecrystal C, was isolated from the EtOAc extract of the dried leaves of Isodon macrophyllus. Its structure was determined on the basis of spectroscopic methods.

关键词： Isodon macrophyllus ent-Abietane diterpenoid Dayecrystal C

Antioxidant,lipid peroxidation inhibition and free radical scavenging efficacy of a diterpenoid compound sugiol isolated from Metasequoia glyptostroboides

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 9-15页

作者： Vivek K.Bajpai Ajay Sharma Sun Chul Kang Kwang-Hyun Baek School of Biotechnology Yeungnam UniversityGyeongsanGyeongbook 712-749Republic of Korea

Objective:To investigate the antioxidant enicacy of a biologically active dilerpenoid compound sugiol isolated from Metasequoia glyptostroboides(***)in various antioxidant ***:An abietane type diterpenoid sugiol,isolated from ethyl acetate extract of *** cones,was analyzed for its antioxidant efficacy as reducing power ability and lipid peroxidation inhibition as well as its ability to scavenge free radicals such as 1,1-diphenyl-2-picryl hydrazyl,nitric oxide,superoxide and hydroxyl ***:The sugiol showed significant and concentration-dependent antioxidant and free radical scavenging ***,the sugiol exerted lipid peroxidation inhibitory effect by 76.3%as compared to a-tocopherol(80.13%)and butylaled hydroxyanisole(76.59%).In addition,the sugiol had significant scavenging activities of l,l-diphenyl-2-picryl hydrazyl,nitric oxide,superoxide and hydroxyl free radicals in a concentration-dependent manner by 78.83%,72.42%,72.99%and 85.04%,when compared to the standard compound ascorbic acid(81.69%,74.62%,73.00%and 73.79%)and a-tocopherol/butylated hydroxyanisole(84.09%,78.61%,74.45%and 70.02%),***:These findings justify the biological and traditional uses of *** or its secondary metabolites as confirmed by its promising antioxidant efficacy.

关键词： Sugiol diterpenoid Antioxidant Free radicals Lipid peroxidation

A New Epi‑neoverrucosane‑type diterpenoid from the Liverwort Pleurozia subinfata in Borneo

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Natural Products and Bioprospecting 2020年第1期10卷 51-56页

作者： Takashi Kamada Mary Lyn Johanis Shean-Yeaw Ng Chin-Soon Phan Monica Suleiman Charles SVairappan Department of Materials and Life Science Faculty of Science and TechnologyShizuoka Institute of Science and Technology2200-2 ToyosawaFukuroiShizuoka 437-8555Japan Institute for Tropical Biology and Conservation Universiti Malaysia Sabah88400 Kota KinabaluSabahMalaysia

New bioactive 13-epi-neoverrucosane diterpenoid,5β-acetoxy-13-epi-neoverrucosanic acid(1)along with three known secondary metabolites,13-epi-neoverrucosan-5β-ol(2),chelodane(3)and(E)-β-farnesene(4)were isolated from the MeOH extract of east Malaysia’s liverwort Pleurozia *** chemical structure of new compound was elucidated by the analyses of its spectroscopic data(FTIR,NMR and HR-ESI-MS).These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for *** in *** 3 was widespread in marine sponges however this is the frst record for 3 to be found in *** metabolites were tested for their antifungal potentials against selected fungi from the marine *** 1 exhibited efective antifungal activity against Lagenidium thermophilum.

关键词： Epi-neoverrucosane diterpenoid Pleurozia subinfata Liverwort Borneo

Structure of a New diterpenoid From Euphorbia micractina

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Chinese Science Bulletin 1993年第10期38卷 856-859页

作者：石建功贾忠建王奇光 The State Key Laboratory of Applied Organic Chemistry Institute of Organic Chemistry Lanzhou University Lanzhou 730000 PRC

The genus Euphorbia has skin irritant, tumor promoting and anficancer activities. In recent years considerable attention has been devoted to the study on its chemical constitutents. In this note, we report a new compound, with the name of euphoractine A（1）, isolated from Euphorbia micractina, which has been identified to be a tetracyclic diterpenoid with a novel carbon skeleton by IR, EIMS, 1HNMR and 13

关键词： Euphorbia micractina Euphorbiaceae diterpenoid euphoractine A X-ray structural analysis.

Scapaundulin C,a novel labdane diterpenoid isolated from Chinese liverwort Scapania undulate,inhibits acetylcholinesterase activity

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Chinese Journal of Natural Medicines 2015年第12期13卷 933-936页

作者： KANG Ya-Qi ZHOU Jin-Chuan FAN Pei-Hong WANG Shu-Qi LOU Hong-Xiang Department of Natural Products Chemistry School of Pharmaceutical SciencesShandong University

In the present study, scapaundulin C(1), a new labdane diterpenoid, and four related known compounds scapaundulin A(2), 5?, 8?, 9?-trihydroxy-13E-labden-12-one(3), 5?, 8?-dihydroxy-13E-labden-12-one(4), and(13S)-15-hydroxylabd-8(17)-en-19-oic acid(5), were isolated from the Chinese liverwort Scapania undulate(L.) Dum., using column chromatography. The structures of these compounds were determined on the basis of 1D- and 2D-NMR analyses. The acetylcholinesterase(Ach E) inhibitory activity was evaluated using a bioautographic TLC assay and the cytotoxic activity was evaluated by the MTT method. All the compounds were reported for the first time to exhibit moderate Ach E inhibitory activity with minimal inhibitory quantities ranging from 250 to 500 ng. All the compounds were tested for their cytotoxicity against five human tumor cell lines, A549, K562, A2780, Hela, and HT29, and compounds 3 and 4 exhibited moderate inhibitory effects on the growth of A2780 cells.

关键词： Liverwort Scapania undulate Labdane diterpenoid AChE inhibitory activity Cytotoxic activity

A New diterpenoid from Aralia fargesii

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Acta Botanica Sinica 2002年第4期44卷 474-476页

作者：张聿梅杨峻山中国协和医科大学中国医学科学院药用植物研究所北京100094

Four diterpenoids, including a new ent-kaurane diterpene (1), were isolated from the rhizome of Aralia fargesii Franch. On the basis of chemical and spectral evidence (IR, EI-MS, HREI-MS, H-1-NMR, C-13-NMR and HMQC), the structure of compound 1 was established to be 17-acetoxy-16alpha-ent-kauran-19-oic acid The other three known compounds were identified as ent-pimera-8(14) 15-dien-19-oic acid (2), 16alpha-hydroxy-( -)-kauran-19-oic acid (3) and 16alpha-17-dihydroxy-ent-kauran-19-oic acid (4). The three known diterpenoids were obtained from this plant for the first time.

关键词： Aralia fargesii diterpenoid 17-acetoxy-16 alpha-ent-kauran-19-oic acid