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Effects of diquafosol sodium in povidone iodine-induced dry eye model

International Journal of Ophthalmology(English edition) 2023年第12期16卷 1919-1927页

作者： Can Zhang He Wang Dong-Yan Chen Kai Zhao Wei Wang Ming-Xin Li Department of Ophthalmology the First People’s Hospital of LianyungangLianyungang 222000Jiangsu ProvinceChina Department of Ophthalmology the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Ophthalmology Zhang Ye People’s Hospital Affiliated to Hexi UniversityZhangye 734000Gansu ProvinceChina

AIM:To investigate the effects of diquafosol sodium(DQS)for dry eye model induced with povidone-iodine(PI)***:Ten Sprague Dawley rats as the control *** Sprague Dawley rats were used to establish the dry eye model with stimulation of 10 g/L PI for 14d,then divided rats into three groups:dry eye group with no treatment(DED group,n=10);phosphate buffer saline treated group(PBS group,n=10);diquafosol treated group(DQS group,n=10).Clinical changes were observed by tear production test,fluorescein staining,tear breakup time(TBUT)test,corneal confocal microscope and ocular surface comprehensive *** were collected on day 10 of treatment for hematoxylin-eosin(HE),periodic acid-Schiff(PAS),and alcian blue *** assay,polymorphonuclear(PMN)and mucin 1(MUC1)immunofluorescence were performed and corneal ultrastructural changes were detected by electron ***:Compared with DED and PBS groups,tear production(7.26±0.440 vs 4.07±0.474 mm;7.26±0.440 vs 3.74±0.280 mm;all P<0.01)and TBUT(7.37±0.383s vs 1.49±0.260s;7.37±0.383s vs 1.42±0.437s;all P<0.01)were significantly increased in DQS ***,PAS,and alcian blue staining and MUC1 immunofluorescence showed mucins and conjunctival goblet cells density(8.45±0.718 vs 5.21±0.813 cells/0.1 mm^(2);8.45±0.718 vs 5.36±0.615 cells/0.1 mm^(2);all P<0.01)increased in DQS *** microscopy,PMN immunofluorescence and TUNEL staining showed inflammatory infiltration and corneal epithelial cells apoptosis decreased in DQS *** increased number of microvilli in corneal epithelial and the recovered cell junction were observed in DQS ***:PI instillation can induce goblet cells and mucin loss,epithelial cell apoptosis and inflammation,which are consistent with the pathological manifestations of dry *** can repair the ocular surface damage caused by PI,reduce corneal inflammation,inhibit corneal epithelial cell apoptosis,promote mucin secretion and maintain te

关键词： diquafosol povidone iodine dry eye mucin inflammation tear film rats

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The effect of 3% diquafosol on the improvement of ocular surface post cataract surgery:A meta-analysis for time of intervention

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 1-7页

作者： Yuhang Zhang Ying Qi Xiaohang Xie Fengyan Zhang The Division of Ophthalmology and Vision Science Department of OphthalmologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina College of Medicine Zhengzhou UniversityZhengzhouChina

Purpose The effect of interventional time for 3% diquafosol reatment in post-cataract surgery has not been well established.A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment *** Studies were performed based on 5 databases:PubMed,Cochrane Library,Web of Science,Embase,and China National Knowledge *** on changes in Schirmer’s test,tear breakup time(TBUT),corneal staining score,and OSDI score were collected for *** A total of 621 affected eyes from 9 independent clinical studies were included.6 studies conducted Schirmer's test after the application of 3% ***-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application(less than or equal to 1 month)(WMD=0.14,P=0.27,95% CI:-0.11 to 0.39),but was statistically different for long-term application(longer than or equal to 3 months)(WMD=0.76,P=0.03,95% CI:0.08 to 1.45).For the corneal fluorescence staining score,the data from 6 studies indicated that the improvement was statistically significant for short-term application(WMD=-0.40,P<0.00001,95% CI:-0.72 to-0.08)and but not long-term application(WMD=-0.21,P=0.26,95% CI:-0.57 to 0.15).For TBUT,the data from 9 studies indicated that both short-term and long-term application showed significant improvement(WMD=1.70,P<0.00001,95% CI:1.38 to 2.03;WMD=1.52,P<0.00001,95% CI:1.09 to 1.95).Similar results were observed in data from 5 studies with OSDI scores,where both short-term and long-term application showed statistically significant improvements(WMD=-5.41,P<0.00001,95% CI:-7.02 to-3.81;WMD=-6.10,P<0.00001,95% CI:-8.52 to-3.67).Conclusions The application of 3% DQS in post-operative cataract patients has a positive effect on improving the ocular surface ***-term application resulted in lower corneal staining scores,prolonged TBUT,and imp

关键词： diquafosol Cataract surgery Ocular surface Meta-analysis

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Changes of tear film lipid layer thickness by 3% diquafosol ophthalmic solutions in patients with dry eye syndrome

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1555-1560页

作者： Dong-Hyun Kang Yong-Woo Lee Kyu-Yeon Hwang Kyung-Min Koh Young-A Kwon Byung-Yeop Kim Sang-Wroul Song Kook-Young Kim Myung-Gok Eye Research Institute Department of Ophthalmology Kim’s Eye Hospital Konyang University College of Medicine

AIM: To evaluate the quantitatively changes in lipid layer thickness(LLT) when 3% diquafosol eye drop is used for dry eye patients using the tear film interferometer. METHODS: A total 124 participants(32 males, 92 females;mean age, 28.9 y) diagnosed with dry eye disease(DED) received topical instillation of 4 ophthalmic solutions in one eye: diquafosol, normal saline, 0.1% sodium hyaluronate and 0.3% gatifloxacin, in a masked manner. LLT was measured using an interferometer at baseline and 20 min after the instillation of each ophthalmic ***: Changes of LLT after instillation(nm, mean± standard error) were as follows: 12.6±2.0 for diquafosol(Pdiquafosol increases tear film LLT in DED patients. diquafosol 3% eye drop might be effective treatment option of evaporative DED with meibomian gland dysfunction.

关键词： diquafosol ophthalmic solutions dry eye syndrome tear film lipid layer thickness

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FDA要求diquafosol的更多数据

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国外药讯 2004年第4期 21-21页

作者：李燕燕

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