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Chinese Science Bulletin 1987年第1期32卷 72-页

作者：张纯贞战书莉谢晶曦 Institute of Materia Medica Chinese Academy of Medical Sciences Beijing Institute of Materia Medica

Synthetic biphenyl diester, dimethyl 4, 4’-dimethoxy-5, 6, 5′, 6′-bismethylenedioxybi-phenyl-2, 2′-dicarboxylate is a new antihepatitic drug. Pharmacological studies showed that biphenyl diester has relatively strong SGPT lowering activity. It has been used clinically for the treatment of chronic hepatitis and lowering the elevated SGPT caused by certain chemicals and medicaments. Owing to the presence of four ortho substituents on the 2, 2′ and 6, 6′position in the biphenyl skeleton, the molecule can exist in two atropisomers.

关键词： biphenyl lowering dimethoxy chemicals ortho SGPT DICARBOXYLATE dimethoxy-5 skeleton elevated

Direct conversion of furfural to levulinic acid/ester in dimethoxymethane:Understanding the mechanism for polymerization

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Green Energy & Environment 2019年第4期4卷 400-413页

作者： Yuewen Shao Xun Hu Zhanming Zhang Kai Sun Guanggang Gao Tao Wei Shu Zhang Song Hu Jun Xiang Yi Wang School of Material Science and Engineering University of JinanJinan250022China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037JiangsuChina School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan430074China

This study investigated the conversion of furfural to 5-hydroxymethylfurfural(HMF)and further to levulinic acid/ester in dimethoxymethane under acidic conditions,with the particular focus on understanding the mechanism for polymer *** results showed that furfural could react with dimethoxymethane via electrophilic substitution reaction to form HMF or the ether/acetal of HMF,which were further converted to levulinic acid and methyl *** polymerization of furfural and the cross-polymerization between dimethoxymethane and the levulinic acid/ester produced were the main side reactions leading to the decreased yields of levulinic acid/*** to the other solvent,methanol as the co-solvent helped to alleviate but not totally inhibited the occurrences of the polymerization,as the polymerization reactions via aldol condensation did not eliminate the C=O *** a consequence,the polymerization reactions continued to *** co-solvent used such as guaiacol,dimethyl sulfoxide and acetone interfered with the transformation of furfural to HMF or aided the polymerization *** polymer produced from the reactions between furfural and DMM was different from that produced from levulinic acid/*** former had a higher crystallinity,while the latter was more *** DRIFTS and TG-MS studies showed that the polymer had the carboxylic group,methyl group and the aliphatic structure in the *** removal of these functionalities was accompanied by the aromatization of the *** condensation of DMM with levulinic acid/ester was the key reason for the diminished production of levulinic acid/ester.

关键词： polymerization methane dimethoxy

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HEMATOPOIETIC SYSTEM

China Medical Abstracts(Internal Medicine) 2002年第1期19卷 38-40页

副凋亡:肿瘤细胞克服凋亡抵抗的途径(英文)

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中国药理学与毒理学杂志 2015年第S1期29卷 13-14页

作者： KyeongSookCHOI Department of Biochemistry Ajou University School of Medicine

Since inherent or acquired cellular resistance to various pro-apoptotic treatments often leads to therapeutic failure,a better understanding of alternative non-apoptotic pathways may facilitate the design of novel therapeutics against malignant cancer *** is a cell death mode characterized by extensive vacuolization that arises via dilation of the endoplasmic reticulum(ER)and mitochondria,without any apoptotic *** found that curcumin,dimethoxycurcumin(a more stable analog of curcumin),and celastol kill malignant cancer cells via induction of paraptosis as a main cell death *** on the underlying mechanisms of paraptosis revealed that simultaneous proteasomal inhibition and mitochondrial Ca2+ overload can effectively induce paraptosis in cancer *** Ca2+ overload can be achieved not only by inhibition of mitochondrial Na+/Ca2+ exchanger but also by IP3 receptor-or ryanodine receptor-mediated release of Ca2+ from the ER and its subsequent mitochondrial Ca2+ uniporter-mediated Ca2+ influx into *** malignant cancer cells are more vulnerable to oxidative stress and ER stress than normal cells,clarification of the molecular basis of paraptosis that targets mitochondria and the ER at the same time may provide a rational therapeutic strategy for effectively killing resistant cancer cells.

关键词： paraptosis cancer curcumin dimethoxy curcumin

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两种药用植物的化学成分及生物活性研究

两种药用植物的化学成分及生物活性研究

作者：郭晓江山东大学

学位级别：硕士

余甘子系藏族习用药材,为大戟科(Euphorbiaceae)叶下珠属(Phyllanthus L.)植物余甘子.Phyllanthus emblica L.的干燥成熟果实,冬季至次春果实成熟时采收。2005年《中国药典》记载的余甘子功能主治为：清热凉血,消食健胃,生津止咳。用于... 详细信息

余甘子系藏族习用药材,为大戟科(Euphorbiaceae)叶下珠属(Phyllanthus L.)植物余甘子.Phyllanthus emblica L.的干燥成熟果实,冬季至次春果实成熟时采收。2005年《中国药典》记载的余甘子功能主治为：清热凉血,消食健胃,生津止咳。用于血热血瘀,消化不良,腹胀,咳嗽,喉痛,口干。文献记载余甘子具有较强的抗氧化活性,是联合国卫生组织指定的全世界推广种植的3种保健植物之一。本课题对余甘子果实进行了系统的化学成分研究,共分离并鉴定了28个化合物,包括9个木脂素类化合物：vermixocins B (1), vermixocins A (2), vermixocins D(3),4-羰基松脂酚(4),丁香脂素(5),杜仲树脂酚(6),鹅掌揪树脂酚A(7),7S,8R-4,9,9'-trihydroxy-3,4'-dimethoxy-8-O-3'-neolignan (8a)7R,8S-4,9,9'-trihydroxy-3,4'-dimethoxy-8-O-3'-neolignan (8b),异落叶松树酯醇(9);1个生物碱类化合物：divaricataesters D (10);1个倍半萜类化合物：4-hydroxy phyllaemblic acid methyl ester (11);12个酚酸及其衍生物：3,4,8,9,10-五羟基尿石酸(12),没食子酸(13),香草酸(14),香兰素(15),没食子酸甲酯(16),没食子酸乙酯(17),对羟基苯甲酸甲酯(18),对苯二甲酸二丁酯(19),松柏醛(20),丁香醛(21),反式肉桂酸(22)和咖啡酸甲酯(23);1个甾体类化合物：β-谷甾醇(24);1个糠醛类化合物：5-羟甲基糠醛(25);两个多元酸酯：黏酸-1-甲酯-6-乙酯(26)和苹果酸二乙酯(27)。其中,化合物3,10,11为新化合物,化合物1,2,4,5,6,7,8,9,12,14,15,18,20,21,23,27为首次从该植物中分离得到。对余甘子中得量较大的化合物12,13和17进行了自由基清除实验和细胞氧化损伤保护活性研究,结果表明,化合物13和17具有潜在Nrf2诱导活性,化合物17对H2O2引起的细胞氧化损伤具有显著保护作用。三叶青Tetrastigma hemsleyanum为葡萄科(Vitaceae)崖爬藤属(Albertisia Becc.)植物,主要分布于长江以南各地。三叶青主要以块根入药,具有清热解毒、祛风化痰、活血止痛、理气健脾等作用,临床内服可治疗小儿高热惊厥、痢疾、支气管炎、肺炎、咽喉炎、肝炎及病毒性脑膜炎等,外敷可治毒蛇咬伤、扁桃体炎、蜂窝织炎、跌打损伤等。本课题对三叶青块根进行了系统的化学成分研究,已鉴定了10个化合物：香橙素(S1),山奈酚-3-O-β-D-葡萄糖苷(S2),槲皮素苷(S3),烟花苷(S4),刺槐素(S5),根皮苷(S6),云杉新苷(S7),1’-O-苯乙基-α-L-吡喃鼠李糖基-(1→6)-β-D-吡哺葡萄糖苷(S8),水杨酸(S10)。

关键词：化学成分余甘子三叶青 dimethoxy 生物活性叶下珠属木脂素类化合物细胞氧化损伤化合物结构崖爬藤属

密花石豆兰和紫茉莉两种药用植物化学成分的研究

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密花石豆兰和紫茉莉两种药用植物化学成分的研究

作者：徐俊驹云南师范大学

学位级别：硕士

本文对两种云南产药用植物密花石豆兰[Bulbophyllum odoratissimum(J. E. Smith)Lindl]和紫茉莉(Mirabilis jalapa L)的化学成分进行了研究。密花石豆兰是兰科石豆兰属植物,其全草在民间作药用,具有润肺化痰、行气止痛的功能,用于肺结... 详细信息

本文对两种云南产药用植物密花石豆兰[Bulbophyllum odoratissimum(J. E. Smith)Lindl]和紫茉莉(Mirabilis jalapa L)的化学成分进行了研究。密花石豆兰是兰科石豆兰属植物,其全草在民间作药用,具有润肺化痰、行气止痛的功能,用于肺结核、慢性炎症和接骨等。近年来,国内外对著名中药石斛[兰科石斛属(Dendrobium)多种植物的茎]的开发应用较多。石斛属植物生长条件苛刻,随着环境的破坏及人为掠夺性采挖,资源越来越少,有些物种已濒临灭绝的边缘。石豆兰属等近缘植物常混作或作石斛类药材应用。为了解石豆兰属植物的化学成分及能否替代中药石斛应用,我们对云南产密花石豆兰的化学成分进行了研究。其全草通过溶剂提取、硅胶柱层析和Sephadex LH-20柱层析等方法共分得25个成分。波谱分析(核磁共振氢谱、碳谱、DEPT谱、NOESY谱、HMBC谱、HMQC谱、H-H COSY谱和质谱等)鉴定了其中18个化合物的结构。包括菲、菲醌、9,10-二氢菲及其二聚体、联苄和其它芳香族化合物、甾体和脂肪酸等类型。结构分别为3, 7-dihydroxy-2, 4, 6-trimethoxyphenanthrene (1)、1, 3', 5', 7-tetrahydroxy-4, 7'-dimethoxy-9, 9', 10, 10'-tetrahydro-2, 2'-biphenanthrene (2)、3', 4, 5', 7-tetrahydroxy-2, 7'-dimethoxy-9, 9', 10, 10'-tetrahydro-1, 2'-biphenanthrene (3)、moscatin (2, 5-dihydroxy-4-methoxyphenanthrene, 4)、7-hydroxy-2, 3, 4-trimethoxy-9, 10-dihydrophenanthrene (5)、coelonin (2, 7-dihydroxy-4-methoxy-9, 10-dihydrophenan threne, 6)、4, 7-dihydroxy-2-methoxy-9, 10-dihydrophenanthrene (7)、densiflorol B (7-hydroxy-2-methoxy-1, 4-phenanthraquinone, 8)、7-hydroxy-2, 6-dimethoxy-1, 4-phenanthraquinone (9)、gigantol (10)、batatasin Ⅲ (11)、tristin (12)、2', 2'-二乙基邻苯二甲酸二已酯[bis(2', 2"-diethylhexyl) phthalate, 13]、邻苯二甲酸二丁酯(dibutyl phthalate, 14)、β-谷甾醇(β-sitosterol, 15)、香草酸(vanillic acid, 16)、丁香醛(syringaldehyde, 17)和二十九烷酸(nonacosanoic acid, 18)。化合物1～3为新化合物,其余均为首次从密花石豆兰中分得。对化合物4～6、8、10和11进行人白血病细胞株(HL-60)和人肝癌细胞株(SMMC-7721)抑制活性测试,结果表明这些化合物体外有不同程度的抑制人白血病细胞株和人肝癌细胞株活性。紫茉莉为紫茉莉科紫茉莉属植物,根叶可供药用,有清热解毒、活血调经和滋补的功效,种子白粉可去面部癍痣粉刺。我们在寻找植物来源DNA裂解剂的

关键词：植物化学成分紫茉莉根石豆兰 dimethoxy dihydroxy 甲氧基质子硅胶柱层析二氧次甲基二十九烷 sitosterol

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曲昔匹特体内代谢过程及种属差异性研究

四川生理科学杂志 1994年第1期16卷 44-44页

作者：洪诤华西医科大学药学院

日本入仑勉等1979年报告了新药曲昔匹持(KU—54)在大鼠、小鼠、豚鼠、犬及人体内的代谢过程.结果如下: 1、尿和胆汁的代谢物包括有M—1为原形药,M—2为5—(3,4,5—trimethoxy—benzamido)-2-piperidine,M-3为3—(4.5—dimethoxy-3-hydr... 详细信息

日本入仑勉等1979年报告了新药曲昔匹持(KU—54)在大鼠、小鼠、豚鼠、犬及人体内的代谢过程.结果如下: 1、尿和胆汁的代谢物包括有M—1为原形药,M—2为5—(3,4,5—trimethoxy—benzamido)-2-piperidine,M-3为3—(4.5—dimethoxy-3-hydroxybenzamido)piperidine,和M—4为3—(3,4—dimethoxy—4—hydroxybenzamido)piperidine。是经过β—醛糖酸酶/芳基硫酸酶的水解后,用物理化学方法分析、鉴定(包括熔点、红外(IR)、质谱(Mass)、顺磁共震(PMR)等法),并用薄层层析密度计(TLC—densitometry)加以估量。

关键词：曲昔匹特体内代谢过程 dimethoxy 差异性研究物理化学方法密度计醛糖酸芳基薄层层析药曲