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Optimal aspect ratio of endocytosed spherocylindrical nanoparticle

Frontiers of physics 2015年第1期10卷 119-123页

作者： Ying-Bing Chen Yan-Hui Liu Yah Zeng Wei Mao Lin Hu Zong-Liang Mao Hou-Qiang Xu Key Laboratory of Animal Genetics Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education College of Animal Science Guizhou University Guiyang 550025 China Soft Condensed Matter Laboratory College of Science Guizhou University Guiyang 550025 China State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China College of Civil Engineering Guizhou University Guiyang 550025 China

Recent simulations have demonstrated that bioparticle size and shape modulate the process of endocytosis, and studies have provided more quantitative information that the endocytosis efficiency of spherocylindrical bioparticles is decided by its aspect ratio. At the same time, the dimensions of the receptor-ligand complex have strong effects on the size-dependent exclusion of proteins within the cellular environment. However, these earlier theoretical works including simulations did not consider the effects of ligand-receptor complex dimension on the endocytosis process. Thus, it is necessary to resolve the effects of ligand-receptor complex dimension and determine the optimal aspect ratio of spherocylindrical bioparticles in the process of endocytosis. Accordingly, we proposed a continuum elastic model, of which the results indicate that the aspect ratio depends on the ligand-receptor complex dimension and the radius of the spherocylindrical bioparticle. This model provides a phase diagram of the aspect ratio of endocytosed spherocylindrical bioparticles, the larger aspect ratio of which appears in the phase diagram with increasing ligand density, and highlights the bioparticle design.

关键词： cellular uptake depletion effects dimension of ligand-receptor complex elasticity theory

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