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Anti-herpes simplex virus activities of monogalactosyl diglyceride and digalactosyl diglyceride from Clinacanthus nutans, a traditional Thai herbal medicine

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 192-197页

作者： Sirada Pongmuangmul Supaporn Phumiamorn Phanchana Sanguansermsri Nalin Wongkattiya Ian Hamilton Fraser Donruedee Sanguansermsri Faculty of Medical Science Naresuan University Regional Medical Sciences Center Nakhonswan Department of Medical Sciences Ministry of Health Institute of Biological Products Department of Medical Sciences Ministry of Health Faculty of Science Maejo University School of Chemistry Monash University Centre of Excellence in Medical Biotechnology Faculty of Medical Science Naresuan University

Objective: To evaluate the monogalactosyl diglyceride(MGDG) and digalactosyl diglyceride(DGDG) from Clinacanthus nutans(C. nutans) for their in vitro antiviral activities against herpes simplex virus type 1(HSV-1) and type 2(HSV-2) by plaque reduction ***: MGDG and DGDG were extracted with chloroform from C. nutans *** and DGDG were separated from chloroform crude extract using column chromatography, characterized by thin layer chromatography and quantified by high performance liquid chromatography. The anti HSV-1 and 2 activity against pre-treatment and posttreatment of the compounds was evaluated using plaque reduction assay. The cytotoxicity of the extract and the compounds on Vero cells were performed by MTT ***: MGDG and DGDG obtained by column chromatography showed identical profiles as standard MGDG and standard DGDG using thin layer chromatography and high performance liquid chromatography. MGDG and DGDG from C. nutans showed 100%inhibition of HSV-1 replication at the post step of infection at noncytotoxic concentration with IC50 values of 36.00 and 40.00 mg/m L, and HSV-2 at 41.00 and 43.20 mg/mL,respectively. Moreover, MGDG and DGDG from C. nutans were demonstrated to have antiherpes simplex activity at the same level as standard synthetic compounds. In contrast, pretreatment of Vero cells with MGDG and DGDG before HSV-1 and HSV-2 infection did not show inhibitory effect against these viruses. MGDG and DGDG exhibited antiviral activity against HSV-1 with selectivity index of 26.00 and 23.00 and HSV-2 of 23.30 and ***: MGDG and DGDG from C. nutans, a traditional Thai herbal medicine illustrated inhibitory activity against HSV-1 and HSV-2, probably by inhibiting the late stage of multiplication, suggesting their promising use as anti-HSV agents.

关键词： Glycoglycerolipids Monogalactosyl diglyceride digalactosyl diglyceride Clinacanthus nutans Herpes simplex virus type 1 Herpes simplex virus type 2 Antiviral activity

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Thermal stability of oxygen evolution in photosystem Ⅱ core complex in the presence of digalactosyl diacylglycerol

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Chinese Science Bulletin 2002年第24期47卷 2089-2092页

作者： YANG Zhenle, LI Liangbi & KUANG TingyunPhotosynthesis Research Center, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Photosynthesis Research Center Institute of Botany Chinese Academy of Sciences Beijing China

The influence of digalactosyldiacylglycerol (DGDG), one of the photosynthetic membrane lipids, on heat inactivation of the process of oxygen evolution has been studied in vitro in photosystem Ⅱ(PS Ⅱ) core complex. It was found that the temperature of semi-inactivation of oxygen evolution in the complex increased from 40.0 to about 43.0℃ in the presence of DGDG with 5-min heat treatment in the dark. Furthermore, when PS Ⅱ core complex was incubated for 5 min at 45.0℃, the oxygen evolution in the complex was completely lost, whilst the DGDG-complexed PS Ⅱ core complex still retained a 16% of activity (100% for 25.0℃). In addition, a 1-h incubation at 38.0℃ inactivated absolutely the oxygen evolution for the PS Ⅱ core complex. By contrast, there remained about 20% of activity (zero time for 100%) for the complex in the presence of DGDG under the same condition. These results indicate a new role of DGDG in the protection of PS Ⅱ core complex against the deleterious effects of temperature. It was

关键词： digalactosyl diacylglycerol photosystem Ⅱ core complex extrinsic protein of 33 kD thermal stability oxygen evolution.

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Comparison of Oxidative Stability of Monogalactosyl Diacylglycerol, digalactosyl Diacylglycerol, and Triacylglycerol Containing Polyunsaturated Fatty Acids

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Food and Nutrition Sciences 2018年第3期9卷 221-234页

作者： Noor Yuslida Binti Hazahari Masashi Hosokawa Kazuo Miyashita Faculty of Fisheries Sciences Hokkaido University Hakodate Japan

Oxidative stability of three different lipid classes, namely, monogalactosyl diacylglycerol (MGDG) and digalactosyl diacylglycerol (DGDG) from spinach and edible brown seaweed (Akamoku) and triacylglycerol (TAG) of linseed oil was compared. Analysis of oxygen consumption and polyunsaturated fatty acid (PUFA) composition demonstrated that spinach DGDG had the highest oxidative stability, followed by Akamoku DGDG, Akamoku MGDG, spinach MGDG, and linseed TAG. These results disagree with the order of oxidative stability expected from the average number of bis-allylic positions of each lipid. Additionally, DGDG constituents of both spinach and Akamoku showed higher oxidative stability than their MGDG constituents. The unusual oxidative stability of MGDG and DGDG could be conferred by the protection of bis-allylic positions of the PUFA against oxidative attack by the galactosyl moiety of the GL.

关键词： Oxidative Stability Glyceroglycolipids Monogalactosyl Diacylglycerol digalactosyl Diacylglycerol Triacylglycerol Polyunsaturated Fatty Acids

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