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diffusion tensor imaging of the hippocampus reflects the severity of hippocampal injury induced by global cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第4期17卷 838-844页

作者： Wen-Zhu Wang Xu Liu Zheng-Yi Yang Yi-Zheng Wang Hai-Tao Lu China Rehabilitation Science Institute School of Rehabilitation MedicineCapital Medical UniversityBeijing Bo’ai HospitalChina Rehabilitation Research CenterBeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina Department of Rehabilitation Medicine Beijing Friendship HospitalCapital Medical UniversityBeijingChina Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijingChina

At present,predicting the severity of brain injury caused by global cerebral ischemia/reperfusion injury(GCI/RI)is a clinical *** such an injury,clinical indicators that can directly reflect neurological dysfunction are *** change in hippocampal microstructure is the key to memory formation and *** tensor imaging is a highly sensitive tool for visualizing injury to hippocampal *** hippocampal microstructure,brain-derived neurotrophic factor(BDNF),and tropomyosin-related kinase B(Trk B)levels are closely related to nerve injury and the repair process after GCI/RI,whether these indicators can reflect the severity of such hippocampal injury remains *** address this issue,we established rat models of GCI/RI using the four-vessel occlusion *** tensor imaging parameters,BDNF,and Trk B levels were correlated with modified neurological severity *** results revealed that after GCI/RI,while neurological function was not related to BDNF and Trk B levels,it was related to hippocampal fractional *** findings suggest that hippocampal fractional anisotropy can reflect the severity of hippocampal injury after global GCI/*** study was approved by the Institutional Animal Care and Use Committee of Capital Medical University,China(approval ***-2015-139)on November 9,2015.

关键词： brain-derived neurotrophic factor diffusion tensor imaging fractional anisotropy value global cerebral ischemia/reperfusion injury hippocampus Trk B

diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury

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Neural Regeneration Research 2023年第1期18卷 176-182页

作者： Chang-Bin Liu De-Gang Yang Jun Li Chuan Qin Xin Zhang Jun Liu Da-Peng Li Jian-Jun Li Department of Rehabilitation Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Spinal and Neural Function Reconstruction China Rehabilitation Research CenterBeijingChina China Rehabilitation Science Institute BeijingChina Department of Neurosurgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Based on the Wallerian degeneration in the spinal cord pathways,the changes in synaptic connections,and the spinal cord-related cellular responses that alter the cellular structure of the brain,we presumed that brain diffusion tensor imaging(DTI)parameters may change after spinal cord ***,the dynamic changes in DTI parameters remain *** established a Beagle dog model of T10 spinal cord contusion and performed DTI of the injured spinal *** found dynamic changes in DTI parameters in the cerebral peduncle,posterior limb of the internal capsule,pre-and postcentral gyri of the brain within 12 weeks after spinal cord *** then performed immunohistochemistry to detect the expression of neurofilament heavy polypeptide(axonal marker),glial fibrillary acidic protein(glial cell marker),and NeuN(neuronal marker).We found that these pathological changes were consistent with DTI parameter *** findings suggest that DTI can display brain structure changes after spinal cord injury.

关键词： spinal cord injury diffusion tensor imaging canines pathophysiology cerebrospinal structures corticospinal tract magnetic resonance imaging anisotropic fraction apparent dispersion coefficient

diffusion tensor imaging of spinal microstructure in healthy adults： improved resolution with the readout segmentation of long variable echo-trains

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Neural Regeneration Research 2017年第12期12卷 2067-2070页

作者： Bu-tian Zhang Meng Li Li-li Yu Yi-meng Dai Shao-nan Yu Jin-lan Jiang China-Japan Union Hospital of Jilin University Changchun Jilin Province China

diffusion tensor imaging plays an important role in the accurate diagnosis and prognosis of spinal cord diseases. However, because of technical limitations, the imaging sequences used in this technique cannot reveal the fine structure of the spinal cord with precision. We used the readout segmentation of long variable echo-trains（RESOLVE） sequence in this cross-sectional study of 45 healthy volunteers aged 20 to 63 years. We found that the RESOLVE sequence significantly increased the resolution of the diffusion images and improved the median signal-to-noise ratio of the middle（C4–6） and lower（C7–T1） cervical segments to the level of the upper cervical segment. In addition, the values of fractional anisotropy and radial diffusivity were significantly higher in white matter than in gray matter. Our study verified that the RESOLVE sequence could improve resolution of diffusion tensor imaging in clinical applications and provide accurate baseline data for the diagnosis and treatment of cervical spinal cord diseases.

关键词： nerve regeneration diffusion tensor imaging cervical spinal cord microstructure gray matter white matter readout segmentationof long variable echo-train sequence signal-to-noise ratio fractional anisotropy neural regeneration

diffusion tensor imaging reveals brain abnormality patterns in a patient with semantic dementia

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Neural Regeneration Research 2010年第2期5卷 142-145页

作者： Qiang Yuan Qin Chen Hehan Tang Xintong Wu Qiyong Gong Dong Zhou Ling Zou Department of Neurology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China Huaxi Magnetic Resonance Research Center Department of Radiology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China Division of Medical imaging Faculty of Medicine University of Liverpool Liverpool L69 3GB UK

BACKGROUND： Previous studies regarding primary progressive aphasia （PPA） have focused on progressive, non-fluent aphasia. Little information is available with regard to the use of diffusion tensor imaging compared with conventional magnetic resonance imaging for the detection of subtle structural abnormalities. OBJECTIVE： To investigate and localize brain abnormalities in a Chinese patient with semantic dementia. DESIGN, TIME AND SETTING： A concurrent, non-randomized, case-controlled, neuroimaging, clinical trial was performed at the Department of Radiology, West China Hospital of Sichuan University in March 2009. PARTICIPANTS： One 75-year-old male patient, who was diagnosed with semantic dementia, and 21 age- and gender-matched healthy volunteers were recruited for the study. METHODS： diffusion tensor imaging was used to determine mean diffusion （MD） and fractional anisotropy （FA） in the brains of the patient and the 21 healthy subjects. Voxel-based analysis of MD and FA values was performed using statistical parametric mapping. MAIN OUTCOME MEASURES： MD and FA value maps differences between patient and controls. RESULTS： MD was significantly increased in both cerebra, but was predominant on the left side and expanded to outside of the language-related region. Reduced MD was not detected in any of the brains. FA was shown to be decreased in the corpus callosum, but was increased in the basal ganglia. CONCLUSION： The present study provided clear in vivo magnetic imaging evidence of diffuse brain involvement in semantic dementia. Increases in MD were greater than in FA when brain diffusion alterations were detected, which suggested that MD could be a better marker of disease progression.

关键词： semantic dementia primary progressive aphasia diffusion tensor imaging mean diffusion fractional anisotropy voxel-based analysis

diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects

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World Journal of Clinical Cases 2022年第24期10卷 8450-8462页

作者： Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia Department of Radiology School of Medical SciencesUniversiti Sains MalaysiaHealth CampusKubang Kerian 16150KelantanMalaysia School of Computer Sciences Universiti Sains Malaysia11800 USMPenangMalaysia Department of Neurosciences Hospital Universiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia

Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of *** a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain *** relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in *** tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter ***,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical *** this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals.

关键词： diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing Tractography

diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 975-979页

作者： Qiu-Juan Zhang Dong Wang Zhi-Lan Bai Bai-Chao Ren Xiao-Hui Li Department of Radiology the Second Affiliated Hospital of Xi'an Jiaotong University Department of Ophthalmology the Second Affiliated Hospital of Xi'an Jiaotong University

AIM: To evaluate the value of quantitative diffusion tensor imaging (DTI) in assessing the axonal and myelin damage of the optic nerves and optic radiations in patients with chronic primary angle -closure glaucoma (PACG) by using high -field magnetic resonance (MR) imaging (3T). METHODS: Twenty patients with bilateral chronic PACG and twenty age - and sex matched disease -free control subjects were enrolled. Conventional MRI and DTI were performed on all subjects using 3T MR scanner. Mean diffusivity (MD), fractional anisotropy (FA), axial diffusivities (AD) and radial diffusivities (RD) of each optic nerve and each optic radiation were measured by using post -processing software of DTI studio 2.3, and then compared between left eyes and right eyes and between patients group and control group. The pairedsample t- test were used. RESULTS: There was no abnormality in the shape and signal intensity of the optic nerves and optic radiations in patients group and control group on the conventional MRI. No significant differences were observed in the FA, MD, AD and RD between the right and left optic nerves and optic radiations within patients group and control group (P>0.05). The optic nerves and optic radiations of patients with chronic PACG, as compared with control subjects, had significantly higher MD, AD, RD and significantly lower FA (P<0.05). CONCLUSION: The diffusivity of optic nerves and optic radiations in chronic PACG group showed abnormal and diffusivity parameters could be used markers of axonal and myelin injury in glaucoma.

关键词： primary angle-closure glaucoma chronic optic nerve and optic radiation diffusion tensor imaging magnetic resonance imaging

Detecting dopaminergic neuronal degeneration using diffusion tensor imaging in a rotenone-induced rat model of Parkinson's disease: fractional anisotropy and mean diffusivity values

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Neural Regeneration Research 2017年第9期12卷 1485-1491页

作者： Lan-xiang Liu Dan Du Tao Zheng Yuan Fang Yan-sheng Chen Hui-ling Yi Qing-yuan He Da-wei Gao Qing-lei Shi Department of Magnetic Resonance imaging First Hospital of Qinhuangdao Department of Radiology Peking University Third Hospital College of Environmental and Chemical Engineering Yanshan University Scientific Clinical Specialist Siemens Ltd.

Dopamine content in the basal ganglia is strongly associated with the degree of dopaminergic neuron loss in the substantia nigra pars com- pacta. Symptoms of Parkinson＇s disease might not arise until more than 50% of the substantia nigra pars compacta is lost and the dopamine content in the basal ganglia is reduced by more than 80%. Greater diagnostic sensitivity and specificity would allow earlier detection of Parkinson＇s disease. diffusion tensor imaging is a recently developed magnetic resonance imaging technique that measures mean diffusiv- ity and fractional anisotropy, and responds to changes in brain microstructure. When the microscopic barrier （including cell membranes, microtubules and other structures that interfere with the free diffusion of water） is destroyed and extracellular fluid volume accumulates, the mean diffusivity value increases; when the integrity of the microstructure （such as myelin） is destroyed, fractional anisotropy value decreases. However, there is no consensus as to whether these changes can reflect the early pathological alterations in Parkinson＇s disease. Here, we established a rat model of Parkinson＇s disease by injecting rotenone （or sunflower oil in controls） into the right suhstantia nigra. diffusion tensor imaging results revealed that in the stages of disease, at 1, 2, 4, and 6 weeks after rotenone injection, fiactional anisotropy value decreased, but mean diffusivity values increased in the right substantia nigra in the experimental group. Fractional anisotropy values were lower at 4 weeks than at 6 weeks in the right substantia nigra of rats from the experimental group. Mean diffusivity values were mark- edly greater at 1 week than at 6 weeks in the right corpus striatum of rats from the experimental group. These findings suggest that mean diffusivity and fractional anisotropy values in the brain of rat models of Parkinson＇s disease 4 weeks after model establishment can reflect early degeneration of dopaminergic neurons. ＇Th

关键词： nerve regeneration diffusion tensor imaging fractional anisotropy mean diffusivity magnetic resonance imaging Parkinson's disease rotenone neurodegenerative disease biomarkers substantia nigra tyrosine hydroxylase neural regeneration

Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury

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Neural Regeneration Research 2018年第5期13卷 877-886页

作者： Chang-Bin Liu De-Gang Yang Qian-Ru Meng Da-Peng Li Ming-Liang Yang Wei Sun Wen-Hao Zhang Chang Cai Liang-Jie Du Jun Li Feng Gao Yan Yu Xin Zhang Zhen-Tao Zuo Jian-Jun Li School of Rehabilitation Medicine Capital Medical University Department of Spinal and Neural Function Reconstruction China Rehabilitation Research Center Center of Neural Injury and Repair Beijing Institute for Brain Disorders China Rehabilitation Science Institute Beijing Key Laboratory of Neural Injury and Rehabilitation Beijing China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing ChinaThe Innovation Center of Excellence on Brain Science Chinese Academy of Sciences Sino-Danish College University of Chinese Academy of Sciences Beijing China

Exploring the relationship between different structure of the spinal cord and functional assessment after spinal cord injury is important. Quantitative diffusion tensor imaging can provide information about the microstructure of nerve tissue and can quantify the pathological damage of spinal cord white matter and gray matter. In this study, a custom-designed spinal cord contusion-impactor was used to damage the T_（10） spinal cord of beagles. diffusion tensor imaging was used to observe changes in the whole spinal cord, white matter, and gray matter, and the Texas Spinal Cord Injury Score was used to assess changes in neurological function at 3 hours, 24 hours, 6 weeks, and 12 weeks after injury. With time, fractional anisotropy values after spinal cord injury showed a downward trend, and the apparent diffusion coefficient, mean diffusivity, and radial diffusivity first decreased and then increased. The apparent diffusion-coefficient value was highly associated with the Texas Spinal Cord Injury Score for the whole spinal cord（R = 0.919, P = 0.027）, white matter（R = 0.932, P = 0.021）, and gray matter（R = 0.882, P = 0.048）. Additionally, the other parameters had almost no correlation with the score（P 〉 0.05）. In conclusion, the highest and most significant correlation between diffusion parameters and neurological function was the apparent diffusion-coefficient value for white matter, indicating that it could be used to predict the recovery of neurological function accurately after spinal cord injury.

关键词： nerve regeneration spinal cord injury diffusion tensor imaging fractional anisotropy apparent diffusion coefficient white matter gray matter Texas Spinal Cord Injury Score beagles neural regeneration

Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies

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Frontiers of Medicine 2021年第1期15卷 125-138页

作者： Xueling Suo Du Lei Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041China Department of Psychiatry and Behavioral Neuroscience University of CincinnatiCincinnatiOhioUSA Department of Psychoradiology Chengdu Mental Health CenterChengdu 610041China Department of Neurology West China Hospital of Sichuan UniversityChengdu 610041China Liverpool Magnetic Resonance imaging Centre(LiMRIC)and Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L693GEUnited Kingdom Psychoradiology Research Unit of Chinese Academy of Medical Sciences West China Hospital of Sichuan UniversityChengdu 610041China

This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related ***-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally *** analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in *** with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal *** of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion *** subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory *** cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in *** status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses.

关键词： Parkinson’s disease diffusion tensor imaging fractional anisotropy meta-analysis anisotropic effect size-signed differential mapping