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differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period

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World Journal of Pediatrics 2023年第8期19卷 715-726页

作者： Taynara Amancio de Lima Patricia Aparecida Zuanetti Marina Estima Neiva Nunes Ana Paula Andrade Hamad Department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical SchoolUniversity of São PauloAv.Bandeirantes3900Monte AlegreRibeirão PretoSP14049-900Brazil University Hospital Ribeirão Preto Medical SchoolUniversity of São Paulo(HCFMRP-USP)Ribeirão PretoSPBrazil

Background Neurodevelopmental disorders are a heterogeneous group of conditions that manifest as delays or deviations in the acquisition of expected developmental milestones and behavioral *** spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in communication and social interaction and by repetitive and restricted patterns of behavior,interests and *** aim of this review is to discuss the clinical features of the differential diagnoses of ASD that are prevalent among preschoolers,focusing on their similarities and *** sources The international medical literature search was conducted using PubMed and was revised regarding the subject using single and/or combined keywords as follows:differential diagnosis,preschoolers,diagnostic challenge,attention deficit hyperactivity disorder,intellectual disability,high abilities/giftedness,childhood apraxia of speech,social communication disorder,Landau–Kleffner syndrome,stereotyped movement disorder and excessive screen *** We describe conditions commonly found in clinical practice,taking ASD as a *** addressed converging and divergent aspects of behavior,cognition,communication,language,speech,socialization,and stereotypes for the diagnosis of ASD and other disorders identified as potential differential or comorbid *** The ranking and characterization of symptoms appear to be essential for better understanding the underlying common ground between children with developmental disorders and children with ASD,thus properly diagnosing and directing social,professional,or medication *** detailed discussion adds to the literature since,although ASD differential diagnoses are frequently mentioned and discussed in textbooks and journal articles,they rarely occupy a prominent place as we aimed herein.

关键词： Autism spectrum disorder Clinical features differential diagnosis Neurodevelopmental disorders Preschool

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differential diagnosis of different types of solid focal liver lesions using two-dimensional shear wave elastography

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World Journal of Gastroenterology 2022年第32期28卷 4715-4724页

作者： Jia Guo Dong Jiang Yi Qian Jiao Yu Yi-Jun Gu Yu-Qing Zhou Hui-Ping Zhang Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Ultrasound Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical UniversityShanghai 200433China Department of Infectious Diseases Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical UniversityShanghai 200433China Department of Ultrasound Shanghai Changning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200050China

BACKGROUND The clinical management and prognosis differ between benign and malignant solid focal liver lesions(FLLs),as well as among different pathological types of malignant *** diagnosis of the possible types of solid FLLs is *** previous study confirmed the value of shear wave elastography(SWE)using maximal elasticity(Emax)as the parameter in the differential diagnosis between benign and malignant ***,the value of SWE in the differential diagnosis among different pathological types of malignant FLLs has not been *** To explore the value of two-dimensional SWE(2D-SWE)using Emax in the differential diagnosis of FLLs,especially among different pathological types of malignant *** All the patients enrolled in this study were diagnosed as benign,malignant or undetermined FLLs by conventional *** of FLLs and the periphery of FLLs was measured using 2D-SWE and compared between benign and malignant FLLs or among different pathological types of malignant *** The study included 32 benign FLLs in 31 patients and 100 malignant FLLs in 96 patients,including 16 cholangiocellular carcinomas(CCCs),72 hepatocellular carcinomas(HCCs)and 12 liver ***-five FLLs were diagnosed as undetermined by conventional *** were significant differences between Emax of malignant(2.21±0.57 m/s)and benign(1.59±0.37 m/s)FLLs(P=0.000),and between Emax of the periphery of malignant(1.52±0.39 m/s)and benign(1.36±0.44 m/s)FLLs(P=0.040).Emax of liver metastases(2.73±0.99 m/s)was significantly higher than that of CCCs(2.14±0.34 m/s)and HCCs(2.14±0.46 m/s)(P=0.002).The sensitivity,specificity and accuracy were 71.00%,84.38%and 74.24%respectively,using Emax>1.905 m/s(AUC 0.843)to diagnose as malignant and 23 of 35(65.74%)FLLs with undetermined diagnosis by conventional ultrasound were diagnosed *** Malignant FLLs were stiffer than benign ones and liver metastases were stiffer than primary liver carc

关键词： Focal liver lesions Conventional ultrasound Two-dimensional shear wave elastography differential diagnosis

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differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review

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World Journal of Gastroenterology 2020年第30期26卷 4537-4556页

作者： Mohid S Khan Thomas Walter Amy Buchanan-Hughes Emma Worthington Lucie Keeber Marion Feuilly Enrique Grande Department of Gastroenterology and Neuroendocrine Tumours University Hospital of WalesCardiff CF144XWUnited Kingdom Department d'Oncologie Médicale Hospices Civils de LyonLyon 69003France Evidence Development Costello MedicalCambridge CB12JHUnited Kingdom Medical Affairs IpsenSlough SL13XEUnited Kingdom Health Economics and Outcomes Research IpsenBoulogne-Billancourt 92100France Oncology Department MD Anderson Cancer CenterMadrid 28033Spain

BACKGROUND Approximately 20%of patients with neuroendocrine tumours(NETs)develop carcinoid syndrome(CS),characterised by flushing and *** analogues or telotristat can be used to control symptoms of CS through inhibition of serotonin *** CS is often the cause of diarrhoea among patients with gastroenteropancreatic NETs(GEP-NETs),other causes to consider include pancreatic enzyme insufficiency(PEI),bile acid malabsorption and small intestinal bacterial *** other causes of diarrhoea unrelated to serotonin secretion are mistaken for CS diarrhoea,these treatments may be ineffective against the diarrhoea,risking detrimental effects to patient quality of *** To identify and synthesise qualitative and quantitative evidence relating to the differential diagnosis of diarrhoea in patients with *** Electronic databases(MEDLINE,Embase and the Cochrane Library)were searched from inception to September 12,2018 using terms for NETs and ***,systematic literature review bibliographies and included articles were also *** study designs and publication types were eligible for inclusion if relevant data on a cause(s)of diarrhoea in patients with GEP-NETs were *** were screened by two independent reviewers at abstract and full-text *** synthesis was adapted to synthesise quantitative and qualitative *** definition of qualitative data was expanded to include all textual data in any section of relevant *** Forty-seven publications(44 studies)were included,comprising a variety of publication types,including observational studies,reviews,guidelines,case reports,interventional studies,and opinion *** reported on PEI on/after treatment with somatostatin analogs;9.5%-84%of patients with GEP-NETs had experienced steatorrhoea or confirmed *** reported,14.3%–50.7%of patients received pancreatic enzyme replacement *** causes of diarrhoea

关键词： Carcinoid syndrome Diarrhea differential diagnosis Neuroendocrine tumours Serotonin Systematic review

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differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning

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World Journal of Gastroenterology 2024年第10期30卷 1377-1392页

作者： Yuan-Peng Li Tian-Yu Lu Fu-Rong Huang Wei-Min Zhang Zhen-Qiang Chen Pei-Wen Guang Liang-Yu Deng Xin-Hao Yang College of Physical Science and Technology Guangxi Normal UniversityGuilinGuangxi 541004China Department of Gastroenterology The Affiliated Hospital of South University of Science and TechnologyShenzhen 518000Guangdong ProvinceChina Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically ***,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and *** To develop a method to identify CD and ITB with high accuracy,specificity,and *** A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or *** wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential *** The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and *** Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB.

关键词： Infrared spectroscopy Machine learning Intestinal tuberculosis Crohn’s disease differential diagnosis Inflammatory bowel disease

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Pathological differential diagnosis of solid-pseudopapillary neoplasm and endocrine tumors of the pancreas

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World Journal of Gastroenterology 2010年第8期16卷 1025-1030页

作者： Liu, Bao-An Li, Zhuo-Ming Su, Zhan-San She, Xiao-Ling Cent S Univ Xiangya Basic Med Sch Dept Pathol Changsha 410013 Hunan Peoples R China Cent S Univ Xiangya Hosp 3 Dept Pathol Changsha 410013 Hunan Peoples R China Cent S Univ Xiangya Hosp 2 Dept Pathol Changsha 410006 Hunan Peoples R China

AIM:To investigate differential points of solid-pseudo-papillary neoplasm (SPN) of the pancreas and pancre-atic endocrine tumor (PET).METHODS:Ten cases of SPN and fourteen cases of PET were studied in this retrospective study. Clinical and pathologic features,immunostaining reactions and β-catenin gene mutations were ***:The mean age of SPN patients was 25.6 years and these patients had no specific symptoms. The mean diameter of the tumors was 11.0 cm,9/10 cases were cystic or a mixture of solid and cystic structures,and there was hemorrhage and necrosis on the cut surface in 8/10 (80%) cases. Characteristic pseudo-papillary structure and discohesive appearance of the neoplastic cells were observed in all 10 (100%) cases. The results of immunostaining showed that nuclear expression of β-catenin and loss of E-cadherin in all the cases,was only seen in SPN. Molecular studies discov-ered that 9/10 (90%) cases harbored a point mutation of exon 3 in β-catenin gene. On the other hand,the mean age of PET patients was 43.1 years. Eight of 14 cases presented with symptoms caused by hypoglyce-mia,and the other 6 cases presented with symptoms similar to those of SPN. The mean size of the tumors was 2.9 cm,most of the tumors were solid,only 3/14 (21%) were a mixture of solid and cystic structures,and macroscopic hemorrhage and necrosis were much less common (3/14,21%). Histologically,tumor cells were arranged in trabecular,acinar or solid patterns and demonstrated no pseudopapillary structure and discohesive appearance in all 14 (100%) cases. The results of immunostaining and mutation detection were completely different with SPN that membrane and cytoplastic expression of β-catenin without loss of E-cadherin,as well as no mutation in β-catenin gene in all the cases. CONCLUSION:Both macroscopic and microscopic features of SPN are quite characteristic. It is not difficult to distinguish it from PET. If necessary,immunos-taining of β-catenin and E-cadherin is quite he

关键词： Solid-pseudopapillary neoplasm of the pan-creas Pancreatic endocrine tumor Immunohistochem-istry β-catenin gene differential diagnosis

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Utility of multiple endoscopic techniques in differential diagnosis of gallbladder adenomyomatosis from gallbladder malignancy with bile duct invasion: A case report

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World Journal of Clinical Cases 2020年第2期8卷 464-470页

作者： Li-Jia Wen Jun-Hong Chen Yong-Jin Chen Kai Liu Department of Hepatopancreatobiliary Surgery The First Hospital of Jilin University

BACKGROUND Gallbladder adenomyomatosis(GAM) is a benign lesion, characterized by thickening of the gallbladder wall and a focal mass, which overlap with the features of gallbladder malignancy. Consequently, differential diagnosis of GAM from gallbladder cancer is difficult and approximately 20% of suspected malignant biliary strictures are postoperatively confirmed as benign ***, we report a case in which a preoperative diagnosis of GAM was made by a combination of endoscopic and imaging *** SUMMARY A 40-year-old man was referred to our hospital chiefly for a fever and right upper abdominal pain with dark urine. Enhanced computed tomography showed thickening of the gallbladder wall and a mass in the gallbladder neck with involvement of the hepatic bile ducts, which was suspected to be *** malignancy with bile duct invasion was ruled out by subsequent endoscopic examinations, including endoscopic retrograde cholangiopancreatography, intraductal ultrasound, and Spy Glass. Endoscopic examinations showed a homogeneous hyperechoic lesion with smooth margins of benign bile duct stricture suggestive of inflammatory stenosis of the bile *** patient underwent laparoscopic cholecystectomy. GAM was postoperatively diagnosed and confirmed based on the histopathology results, which are consistent with the preoperative diagnosis. Notably, no malignant event occurred in the patient during a 12-mo follow-up *** A combination of endoscopic techniques may help in the differential diagnosis of GAM from gallbladder cancer.

关键词： Gallbladder adenomyomatosis differential diagnosis Endoscopic retrograde cholangio-pancreatography Intraductal ultrasound SpyGlass Case report

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Multi-slice spiral computed tomography in differential diagnosis of gastric stromal tumors and benign gastric polyps,and gastric stromal tumor risk stratification assessment

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2004-2013页

作者： Xiao-Long Li Peng-Fei Han Wei Wang Li-Wei Shao Ying-Wei Wang Diagnostic Radiology Department The First Medical Center of PLA General HospitalBeijing 100853China Pathology Department The Seventh Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND The biological characteristics of gastric stromal tumors are complex,and their incidence has increased in recent *** stromal tumors(GST)have potential malignant tendencies,and the probability of transformation into malignant tumors is as high as 20%-30%.AIM To investigate the value of multi-slice spiral computed tomography(MSCT)in the differential diagnosis of GST and benign gastric polyps,and GST risk stratification *** We included 64 patients with GST(GST group)and 60 with benign gastric polyps(control group),confirmed by pathological examination after surgery in PLA General Hospital,from January 2016 to June *** differences in the MSCT imaging characteristic parameters and enhanced CT values between the two groups before surgery were *** to the National Institutes of Health’s standard,GST is divided into low-and high-risk groups for MSCT imaging characteristic parameters and enhanced CT *** The incidences of extraluminal growth,blurred boundaries,and ulceration in the GST group were significantly higher than those in the control group(Pdifferential diagnosis of GST and gastric polyp sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and areas under the curve(AUCs)were 73.44%,83.33%,26.56%,16.67%,0.784,*** receiver operating characteristic curves were plotted with the arterial CT value and enhanced peak CT value,with a statistical *** results showed that the sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and AUC value of arterial CT in the differential diagnosis of GST and gastric polyps were 80.18%,62.20%,19.82%,37.80%,and 0.710,*** sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and AUC value of the enhanced peak CT value in the differential diagnosis of GST and gastri

关键词： Multi-slice spiral computed tomography differential diagnosis Gastric stromal tumor Benign gastric polyps Risk stratification

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Potential model for differential diagnosis between Crohn's disease and primary intestinal lymphoma

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World Journal of Gastroenterology 2016年第42期22卷 9411-9418页

作者： Tian-Yu Zhang Yun Lin Rong Fan Shu-Rong Hu Meng-Meng Cheng Mao-Chen Zhang Li-Wen Hong Xiao-Lin Zhou Zheng-Ting Wang Jie Zhong Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine

AIM To evaluate the usefulness of different parameters to differentiate Crohn's disease(CD) from primary intestinal lymphoma(PIL).METHODS The medical records of 85 patients with CD and 56 patients with PIL were reviewed retrospectively. Demographic, clinical, laboratory, endoscopic, and computed tomographic enterography(CTE) parameters were collected. The univariate value of each parameter was analyzed. A differentiation model was established by pooling all the valuable parameters. Diagnostic efficacy was analyzed, and a receiver operating characteristic(ROC) curve was *** The demographic and clinical parameters that showed significant values for differentiating CD from PIL included age of onset, symptom duration, presence of diarrhea, abdominal mass, and perianal lesions(P diagnosis(P 8 mm, aneurysmal dilation, stricture with proximal dilation, "comb sign", mass showing the "sandwich sign", and intussusceptions(P differential diagnosis between CD and PIL.

关键词： Primary intestinal lymphoma Crohn’s disease differential diagnosis Endoscopy CT enterography

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A radiomic nomogram based on an apparent diffusion coefficient map for differential diagnosis of suspicious breast findings

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Chinese Journal of Cancer Research 2018年第4期30卷 432-438页

作者： Bin Hu Ke Xu Zheng Zhang Ruimei Chai Shu Li Lina Zhang Department of Radiology the First Affiliated Hospital of China Medical University Department of Radiology the First Affiliated Hospital of Xi'an Jiaotong University

Objective： To develop and validate a radiomic nomogram based on an apparent diffusion coefficient （ADC） mapfor differentiating benign and malignant lesions in suspicious breast findings classified as Breast Imaging Reportingand Data System （BI-RADS） category 4 on breast magnetic resonance imaging （MR2）.Methods： Eighty-eight patients diagnosed with BI-RADS 4 findings on breast MRI in the First AffiliatedHospital of China Medical University from December 2014 to December 2015 were retrospectively analyzed inthis study. Sixty-three were randomized electronically to establish forecasting models, and the other 25 were usedfor validation. Radiomic features based on the ADC map were generated automatically by Artificial Intelligence Kitsoftware （A.K. software; GE Healthcare, China）. Feature reduction was conducted using the Mann-Whitney testand Spearman correlation after pre-treatment. A prediction model of ADC radiomics was established by logisticlinear regression and cross-validation. A nomogram was established based on ADC radiomic features,pharmacokinetics and clinical features, including the morphology and ADC value for breast BI-RADS 4 lesionson ***： A total of 396 radiomic features were extracted automatically by the A.K. software. Five features wereselected after pre-processing, Mann-Whitney tests and Spearman correlation analysis. The area under the ROCcurve of the prediction model comprising ADC radiomie features was 0.79 when the cutoffvalue was 0.45, and theaccuracy, sensitivity and specificity were 80.0%, 0.813 and 0.778, respectively. A visualized differential nomogrambased on the radiomic score, pharmacokinetics and clinical features was established. The decision curve showedgood ***： ADC radiomie features could provide an important reference for differential diagnosis betweenbenign and malignant lesions in suspicious BI-RADS 4 lesions. The visualized nomogram based on ADC radiomicfeatures, pharmaeokinetics and clinical features m

关键词： ADC radiomics nomogram BI-RADS 4 differential diagnosis

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Blood exosomal micro ribonucleic acid profiling reveals the complexity of hepatocellular carcinoma and identifies potential biomarkers for differential diagnosis

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1195-1208页

作者： Lang-Qing Sheng Jia-Rong Li Hao Qin Ling Liu Da-Dong Zhang Qi Zhang Meng-Li Huang Xiao-Li Li Xiao-Ya Xu Yang-Nian Wei Zi-Shuo Chen Hui Luo Ji-Yang Zhang Cheng-Hui Zhou Hao Chen Ze-Guo Chen Fu-Gen Li Nian-Feng Li Department of Hepatobiliary and Pancreatic Surgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Biliopancreatic Surgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Research and Development Institute of Precision Medicine 3D Medicines Inc.Shanghai 201114Hunan ProvinceChina The Medical Department 3D Medicines Inc.Shanghai 201114China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths worldwide,but there is a shortage of effective biomarkers for its *** To explore blood exosomal micro ribonucleic acids(miRNAs)as potential biomarkers for HCC *** The principal component analysis suggested that daily alcohol consumption could alter the blood exosomal miRNA profiles of hepatitis B virus positive non-HCC patients through miR-3168 and *** miRNA profiles also revealed the tumor stages of HCC *** expression of miR-455-5p and miR-30c-5p,which significantly correlated with better overall survival in tumor tissues,could also be detected in blood *** pairs of miRNAs(miR-584-5p/miR-106-3p and miR-628-3p/miR-941)showed a 94.1%sensitivity and 68.4%specificity to differentiate HCC patients from non-HCC *** specificity of the combination was substantially influenced by alcohol consumption *** This study suggested that blood exosomal miRNAs can be used as new noninvasive diagnostic tools for ***,their accuracy could be affected by tumor stage and alcohol consumption habits.

关键词： Blood exosomal micro ribonucleic acids Biomarker differential diagnosis Alcohol consumption habit Hepatocellular carcinoma Bioinformatics

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