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Diagnostic Value of Dual-Energy CT in Differentiating Malignant and Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

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Journal of Biosciences and Medicines 2021年第4期9卷 54-76页

作者： Kunlin Ye Yongyao Kuang Jianye Liang Xi Xu Changzheng Shi Qingqing Cheng Zijie Jiang Ziyun Xiang Liangping Luo Department of Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou China Department of Medical Imaging Longgang District People’s Hospital of Shenzhen Shenzhen China Department of Medical Imaging Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China

Objectives: To evaluate the diagnostic performance of the quantitative iodine parameters, including Iodine Concentration (IC), Normalized Iodine Concentration (NIC), and λHU, in distinguishing malignant and benign thyroid nodules. Methods: Relevant studies were searched from Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database and other complementary sources from inception to May 20, 2020. Study selection, data extraction, quality assessment, and data analyses were performed following the Cochrane standards and the PRISMA-DTA guideline. Results: Eight studies were included (595 patients with 737 thyroid nodules). The pooled sensitivity, specificity and summary diagnostic odds ratio of IC were 79% (95% CI: 69% - 86%), 76% (95% CI: 65% - 84%) and 11 (95% CI: 5 - 27) respectively;those of NIC were 78% (95% CI: 70% - 85%), 80% (95% CI: 74% - 85%) and 15 (95% CI: 9 - 24) respectively;those of λHU were 80% (95% CI: 71% - 87%), 77% (95% CI: 70% - 83%) and 14 (95% CI: 8 - 24) respectively. Conclusion: DECT can be a potential evaluation tool for thyroid nodules. The NIC may be the most sensitive iodine parameter and could be comparable between different DECT machines in thyroid nodule assessment.

关键词： Thyroid Nodules differential diagnosis Dual-Energy CT Iodine Concentration Meta-Analysis

Endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor:A case report

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World Journal of Clinical Oncology 2020年第12期11卷 1076-1083页

作者： Zhi-Xiong Hu Min-Hua Tan Qiong-Zhen Li Jia-Li Xu Wei Chen Zhi-Hao Xie Yong-Jian Zhou Qing Liang Jian-Hong An Hong Shen Department of Pathology The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina Department of Gynaecology and Obstetrics The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina Department of Radiology The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Department of Pathology Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND To investigate the clinicopathological features of endometrial clear cell carcinoma that has invaded the right oviduct with a cooccurring ipsilateral oviduct adenomatoid *** SUMMARY A case of endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor was collected and analyzed using pathomorphology and *** clear cell carcinoma cells were distributed in a solid nest,papillary,shoe nail-like,and glandular tube-like *** was infiltrative growth,and tumor cells had clear cytoplasm and obvious nuclear *** cancer tissue was necrotic and *** cancer tissue invaded the right *** ipsilateral oviduct also had an adenomatoid *** adenomatoid tumor was arranged in microcapsules lined with flat or cubic cells that were surrounded by smooth muscle *** adenomatoid tumor cells were round in *** Clear cell carcinoma of the endometrium can invade the oviduct and occur simultaneously with tubal adenomatoid *** pathological diagnosis,one should pay close attention to distinguishing whether an endometrial clear cell carcinoma is invading the oviduct or whether it is accompanied by an adenomatoid tumor of the *** is helpful to differentiate these two disease *** clear cell carcinomas express Napsin-A and P16 and are negative for estrogen receptor and progesterone *** presence of endometrial clear cell carcinoma does not affect the expression of CK and calretinin in adenomatoid tumors.

关键词： Endometrium Clear cell carcinoma Oviduct Adenomatoid tumors differential diagnosis Case report

Inflammatory Linear Verrucous Epidermal Nevus with a Novel CSPP1 Mutation: A Case Report and Review of the Literature

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Chinese Journal Of Plastic and Reconstructive Surgery 2020年第4期2卷 248-252页

作者： Jieyi REN Manmei LONG Yuehua LI Bin GU Zhichao WANG Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Pathology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background Inflammatory linear verrucous epidermal nevus(ILVEN)is a rare type of epidermal nevus that occurs in infancy and develops along Blaschko’s *** to its rarity and clinical/histological similarities with other cutaneous disorders,correct diagnosis is sometimes *** the present case,the whole exome sequencing of blood found no germline mutation,but the sequencing of the biopsy specimen revealed a novel potential pathogenic somatic mutation,C>T at rs200881715(p.R698X)in the cspp1 gene,which may provide new insight into the mechanism of *** concerns A 10-year-old girl presented with linear,pruritic,erythematous,scaly,and exophytic verrucous skin lesions on her left thigh,buttock,and hand unilaterally along Blaschko’s lines from the third day after *** Biopsy revealed psoriasiform acanthosis,papillary hyperplasia with orthohyperkeratosis,and parakeratosis of squamous epithelium,which are histological characteristics of *** Owing to the large lesion size and significant refractory response to previous treatments,multiple-stage surgical resections with a tissue expander were *** After surgical resection and defect reconstruction with a tissue expander,the outcome was satisfactory for the patient and her *** recurrence was detected during the follow-up *** ILVEN is a rare type of cutaneous hyperplastic disease,and treatment is extremely *** should be performed at the diagnostician’s discretion or if refractory to conservative *** diagnosis and surgical intervention could result in satisfactory outcomes.

关键词： Inflammatory linear verrucous epidermal nevus Blaschko’s lines Psoriasis differential diagnosis Surgical resection

A safe and molecular-tagged Brucella canis ghosts confer protection against virulent challenge in mice

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A safe and molecular-tagged Brucella canis ghosts confer pro...

MARKER VACCINES AND FUTURE TREND IN PREVENTION OF ANIMAL INFECTIOUS DISEASES

中国畜牧兽医学会兽医公共卫生学分会第六次学术研讨会

作者： Jing Qian Zhaoyang Bu Xulong Lang Guangmou Yan Yanling Yang Xiuran Wang Xinglong Wang Key Laboratory of Jilin Province for Zoonosis Prevention and Control Institute of Military Veterinary MedicineAcademy of Military Medical Sciences Laboratory of Infectious Diseases College of Veterinary MedicineJilin University Key Laboratory of Zoonosis Research Ministry of EducationJilin University Institute of Special Wild Animal & Plant Science Chinese Academy of Agricultural Sciences School of Life Science Jilin Agricultural University

Canine Brucellosis,caused by Brucella canis,is a persistent infectious reproductive disease in *** absence of effective treatment to the intracellular pathogen and the irreversible consequence of infection makes the need of a specific vaccine *** ghosts（BGs） are the empty envelopes of bacteria with no genome content inside,which emerge as a proper vaccine candidate due to its intact outer *** is generally derived from a genetically engineered strain,through the expression of Bacteriophage phiX174 lysis E gene upon *** this study,we combined the homologous recombination（HR） and bacterial ghost technologies,generating a genetically stable *** ghost strain which bears no drug resistance *** the ghost strain grows to OD600 of 0.6,100% inactivation can be achieved under 42°C in 60 *** resultant BGs showed guaranteed safety and comparable immunogenicity to a live *** bacterial B0419 protein was depleted during HR process,which is subsequently proved to work as a molecular tag in distinguishing natural infection and BGs immunization through ***,the BGs also conferred protection against *** RM6/66 and *** 16 ***,the application of current BGs as a vaccine candidate and the corresponding serological diagnostic approach may provide better *** prevention strategy.

关键词： Brucella canis bacterial ghost safety immunogenicity protective efficacy differential diagnosis

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MARKER VACCINES AND FUTURE TREND IN PREVENTION OF ANIMAL INF...

Primary Clear Cell Carcinoma of the Thymus and Literature Comparison of Features

面向21世纪的动物科学与动物医学国际研讨会

作者： Guang-Zhi Tong DVM PhDNational Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute CAAS No.427 Maduan Street Harbin 150001 China Email:gztong@***

＜正＞Although there is a long history in human effort to fight with animal infectious diseases, substantial progress has been made since twenty century. In the past half a century, intensive raising farms were growing fast, chance of pathogen transmission between individual animals or animal herds increased, and virulence of some pathogens might also increased during passing from herd to herd. Therefore, outbreaks of animal infectious diseases in the intensive raising farms were often seen and caused huge economic loss. Vaccination has been considered to be

关键词： Marker vaccine Prevention of animal infectious diseases differential diagnosis

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Primary Clear Cell Carcinoma of the Thymus and Literature Co...

Case Report:Granular Cell Tumor In Breast

2020年浙江省医学会病理学术大会

作者： Xiaomin Dai HaiTao Yang Fang Peng Department of Pathology Zhejiang Hospital Department of Pathology Zhejiang Mingzhou Hospital

Clear cell carcinoma arising from the thymus is considered exceedingly *** shows aggressive clinical behavior and demonstrates frequent local recurrences as well as widespread *** detailed clinical data of one patient with thymic clear cell carcinoma were compiled and review of relevant reported literatures was *** summarized the clinical characteristics,pathological diagnosis of this patient and other reported *** analysis showed that older male patients were more likely to suffer,the manifestations included chest pain and *** patients are asymptomatic,with the tumor being discovered during physical ***,thymic clear cell carcinoma is composed of lobulated structures arranged in hyperchromatic fibrous stroma,the tumor cells are uniform with obvious nucleoli and clear *** establish the correct diagnosis,consideration and exclusion of metastasis and other original tumors in the differential diagnosis by immunohistochemistry,clinical and radiologic correlation is important.

关键词： Thymic carcinoma Clear cell carcinoma differential diagnosis

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Journal of Oncology Research 2019年第3期1卷 4-6页

作者： Ruiz Alcaide,Estefania Lopez Carrizosa Maria Concepcion Gutierrez Pantoja,M Aranzazu Arriaga Pineiro,Jesus M Radiation Oncology Department Central Defence Hospital"Gomez Ulla"MadridSpain Radiology Department Central Defence Hospital"Gomez Ulla"MadridSpain

Granular cell tumor(GCT)of the breast is an unusual neoplasm,tipically benign,it represents between 5-6% of all GCT *** tumors are more common in middle-aged premenopausal women with a greater predilection African American race[1].Nevertheless,there are also cases described in men[2-4].Almost all of them are favorable,the malignant cases are uncommon(only 1-3%).Sometimes it could be clinically and radiologically confused with a malignant breast tumor;so it's very important to make a differential *** choice therapy is an extensive local extirpation with free margins[5],without the need for adjuvant chemotherapy or *** case is a 61-year-old woman with a GCT,and three years ago a history of breast carcinoma in the same breast.

关键词： Breast cancer Benign neoplasm Unusual differential diagnosis