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differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning

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World Journal of Gastroenterology 2024年第10期30卷 1377-1392页

作者： Yuan-Peng Li Tian-Yu Lu Fu-Rong Huang Wei-Min Zhang Zhen-Qiang Chen Pei-Wen Guang Liang-Yu Deng Xin-Hao Yang College of Physical Science and Technology Guangxi Normal UniversityGuilinGuangxi 541004China Department of Gastroenterology The Affiliated Hospital of South University of Science and TechnologyShenzhen 518000Guangdong ProvinceChina Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically ***,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and *** To develop a method to identify CD and ITB with high accuracy,specificity,and *** A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or *** wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential *** The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and *** Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB.

关键词： Infrared spectroscopy Machine learning Intestinal tuberculosis Crohn’s disease differential diagnosis Inflammatory bowel disease

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Analysis of the Role of D-Dimer,Interleukin-6,and Interleukin-18 in differential diagnosis of Pediatric Refractory Mycoplasma pneumoniae Pneumonia

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Journal of Clinical and Nursing Research 2024年第7期8卷 118-122页

作者： Yong Peng Aimin Li The First Hospital Affiliated to Shaoyang College Shaoyang 422000Hunan ProvinceChina Jingzhou Hospital Affiliated to Changjiang University Jingzhou 434020Hubei ProvinceChina

Objective:To analyze the value of D-dimer(D-D),interleukin-6(IL-6),and IL-18 in the differential diagnosis of children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods:The medical records of 92 children with Mycoplasma pneumoniae pneumonia(MPP)treated in the hospital were selected for retrospective analysis from January 2023 to January *** comprehensive examinations such as computed tomography examination of the chest,48 children with general Mycoplasma pneumoniae pneumonia(GMPP)were put in the GMPP group and 44 children with RMPP were grouped in the RMPP *** IL-6,IL-18,and D-D levels were compared between the two groups,and the receiver operating characteristic(ROC)curves were plotted to analyze their value for differential diagnosis of ***:The levels of IL-6,IL-18,and D-D in the RMPP group were higher than those in the GMPP group(Pdifferential diagnosis of IL-6,IL-18,and D-D was higher,and their diagnostic value was ***:Determination of IL-6,IL-18,and D-D levels in children with MPP can further diagnose the children’s condition,which can help physicians formulate targeted treatment plans,and is of great significance to the improvement of the children’s condition,which is worthy of attention.

关键词： Refractory Mycoplasma pneumoniae pneumonia D-dimer Interleukin-6 Interleukin-18 differential diagnosis

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differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period

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世界儿科杂志:英文版 2023年第8期19卷 715-726页

作者： Taynara Amancio de Lima Patricia Aparecida Zuanetti Marina Estima Neiva Nunes Ana Paula Andrade Hamad Department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical SchoolUniversity of São PauloAv.Bandeirantes3900Monte AlegreRibeirão PretoSP14049-900Brazil University Hospital Ribeirão Preto Medical SchoolUniversity of São Paulo(HCFMRP-USP)Ribeirão PretoSPBrazil

Background Neurodevelopmental disorders are a heterogeneous group of conditions that manifest as delays or deviations in the acquisition of expected developmental milestones and behavioral *** spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in communication and social interaction and by repetitive and restricted patterns of behavior,interests and *** aim of this review is to discuss the clinical features of the differential diagnoses of ASD that are prevalent among preschoolers,focusing on their similarities and *** sources The international medical literature search was conducted using PubMed and was revised regarding the subject using single and/or combined keywords as follows:differential diagnosis,preschoolers,diagnostic challenge,attention deficit hyperactivity disorder,intellectual disability,high abilities/giftedness,childhood apraxia of speech,social communication disorder,Landau–Kleffner syndrome,stereotyped movement disorder and excessive screen *** We describe conditions commonly found in clinical practice,taking ASD as a *** addressed converging and divergent aspects of behavior,cognition,communication,language,speech,socialization,and stereotypes for the diagnosis of ASD and other disorders identified as potential differential or comorbid *** The ranking and characterization of symptoms appear to be essential for better understanding the underlying common ground between children with developmental disorders and children with ASD,thus properly diagnosing and directing social,professional,or medication *** detailed discussion adds to the literature since,although ASD differential diagnoses are frequently mentioned and discussed in textbooks and journal articles,they rarely occupy a prominent place as we aimed herein.

关键词： Autism spectrum disorder Clinical features differential diagnosis Neurodevelopmental disorders Preschool

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differential diagnosis of different types of solid focal liver lesions using two-dimensional shear wave elastography

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World Journal of Gastroenterology 2022年第32期28卷 4715-4724页

作者： Jia Guo Dong Jiang Yi Qian Jiao Yu Yi-Jun Gu Yu-Qing Zhou Hui-Ping Zhang Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Ultrasound Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical UniversityShanghai 200433China Department of Infectious Diseases Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical UniversityShanghai 200433China Department of Ultrasound Shanghai Changning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200050China

BACKGROUND The clinical management and prognosis differ between benign and malignant solid focal liver lesions(FLLs),as well as among different pathological types of malignant *** diagnosis of the possible types of solid FLLs is *** previous study confirmed the value of shear wave elastography(SWE)using maximal elasticity(Emax)as the parameter in the differential diagnosis between benign and malignant ***,the value of SWE in the differential diagnosis among different pathological types of malignant FLLs has not been *** To explore the value of two-dimensional SWE(2D-SWE)using Emax in the differential diagnosis of FLLs,especially among different pathological types of malignant *** All the patients enrolled in this study were diagnosed as benign,malignant or undetermined FLLs by conventional *** of FLLs and the periphery of FLLs was measured using 2D-SWE and compared between benign and malignant FLLs or among different pathological types of malignant *** The study included 32 benign FLLs in 31 patients and 100 malignant FLLs in 96 patients,including 16 cholangiocellular carcinomas(CCCs),72 hepatocellular carcinomas(HCCs)and 12 liver ***-five FLLs were diagnosed as undetermined by conventional *** were significant differences between Emax of malignant(2.21±0.57 m/s)and benign(1.59±0.37 m/s)FLLs(P=0.000),and between Emax of the periphery of malignant(1.52±0.39 m/s)and benign(1.36±0.44 m/s)FLLs(P=0.040).Emax of liver metastases(2.73±0.99 m/s)was significantly higher than that of CCCs(2.14±0.34 m/s)and HCCs(2.14±0.46 m/s)(P=0.002).The sensitivity,specificity and accuracy were 71.00%,84.38%and 74.24%respectively,using Emax>1.905 m/s(AUC 0.843)to diagnose as malignant and 23 of 35(65.74%)FLLs with undetermined diagnosis by conventional ultrasound were diagnosed *** Malignant FLLs were stiffer than benign ones and liver metastases were stiffer than primary liver carc

关键词： Focal liver lesions Conventional ultrasound Two-dimensional shear wave elastography differential diagnosis

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Mycobacterium tuberculosis latency-associated antigen Rv1733c SLP improves the accuracy of differential diagnosis of active tuberculosis and latent tuberculosis infection

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Chinese Medical Journal 2022年第1期135卷 63-69页

作者： Lifan Zhang Huimin Ma Shijun Wan Yueqiu Zhang Mengqiu Gao Xiaoqing Liu Division of Infectious Diseases Department of Internal MedicineState Key Laboratory of Complex Severe and Rare DiseasePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Clinical Epidemiology Unit Peking Union Medical CollegeInternational Clinical Epidemiology NetworkBeijing 100730China Center for Tuberculosis Research Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Tuberculosis Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Background: differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) has been a challenge for clinicians in high TB burden countries. The purpose of this study was to improve the accuracy of differential diagnosis of ATB and LTBI by using fluorescent immunospot (FluoroSpot) assay to detect specific Th1 cell immune responses. The novelmycobacterium tuberculosis (MTB) latency-associated antigens Rv1733c and synthetic long peptides derived from Rv1733c (Rv1733c SLP) were used based on virulence factors early secreting antigen target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10).Methods: Fifty-seven ATB cases, including 20 pathogen-confirmed ATB and 37 clinically diagnosed ATB, and 36 LTBI cases, were enrolled between January and December 2017. FluoroSpot assay was used to detect the interferon γ (IFN-γ) and interleukin 2 (IL-2) secreted by the specific T cells after being stimulated with MTB virulence factors ESAT-6 and CFP-10, MTB latency-associated antigens Rv1733c and Rv1733c SLP. The receiver operating characteristic (ROC) curve was used to define the best cutoff value of latency-associated antigens in the use of differentiating ATB and LTBI. The sensitivity, specificity, predictive value, and likelihood ratio of ESAT-6 and CFP-10-FluoroSpot combined with latency-associated antigen in the differential diagnosis of ATB and LTBI were also ***: Following the stimulation with Rv1733c and Rv1733c SLP, the frequency of single IL-2-secreting T cells stimulated by Rv1733c SLP had the largest area under the ROC curve, which was 0.766. With a cutoff value of 1 (spot-forming cells [SFCs]/2.5 × 105 peripheral blood mononuclear cells) for frequency, the sensitivity and specificity of distinguishing ATB from LTBI were 72.2% and 73.7%, respectively. ESAT-6 and CFP-10-FluoroSpot detected the frequency and proportion of single IFN-γ-secreting T cells;the sensitivity and specificity of distinguishing ATB from LTBI were 82.5% a

关键词： Mycobacterium tuberculosis latency-associated antigens Active tuberculosis Latent tuberculosis infection differential diagnosis

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Multi-slice spiral computed tomography in differential diagnosis of gastric stromal tumors and benign gastric polyps,and gastric stromal tumor risk stratification assessment

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2004-2013页

作者： Xiao-Long Li Peng-Fei Han Wei Wang Li-Wei Shao Ying-Wei Wang Diagnostic Radiology Department The First Medical Center of PLA General HospitalBeijing 100853China Pathology Department The Seventh Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND The biological characteristics of gastric stromal tumors are complex,and their incidence has increased in recent *** stromal tumors(GST)have potential malignant tendencies,and the probability of transformation into malignant tumors is as high as 20%-30%.AIM To investigate the value of multi-slice spiral computed tomography(MSCT)in the differential diagnosis of GST and benign gastric polyps,and GST risk stratification *** We included 64 patients with GST(GST group)and 60 with benign gastric polyps(control group),confirmed by pathological examination after surgery in PLA General Hospital,from January 2016 to June *** differences in the MSCT imaging characteristic parameters and enhanced CT values between the two groups before surgery were *** to the National Institutes of Health’s standard,GST is divided into low-and high-risk groups for MSCT imaging characteristic parameters and enhanced CT *** The incidences of extraluminal growth,blurred boundaries,and ulceration in the GST group were significantly higher than those in the control group(Pdifferential diagnosis of GST and gastric polyp sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and areas under the curve(AUCs)were 73.44%,83.33%,26.56%,16.67%,0.784,*** receiver operating characteristic curves were plotted with the arterial CT value and enhanced peak CT value,with a statistical *** results showed that the sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and AUC value of arterial CT in the differential diagnosis of GST and gastric polyps were 80.18%,62.20%,19.82%,37.80%,and 0.710,*** sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and AUC value of the enhanced peak CT value in the differential diagnosis of GST and gastri

关键词： Multi-slice spiral computed tomography differential diagnosis Gastric stromal tumor Benign gastric polyps Risk stratification

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Clinicopathological practice in the differential diagnosis of mucoepidermoid carcinoma from neoplasms with mucinous component

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Chronic Diseases and Translational Medicine 2023年第1期9卷 29-38页

作者： Yuelu Zhu Yan Li Lei Guo Wenbin Li Jiali Mu Haifeng Zhang Xin Li Jianming Ying Haizhen Lu Department of Pathology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:The differential diagnosis of mucoepidermoid carcinoma(MEC)from neoplasm undergoing mucinous features brings more pitfalls to *** specific MAML2 gene rearrangement and histological characteristics may be the ***:Twenty-five tumors with mucinous components were selected for differential diagnosis of *** the cases were detected for MAML2 gene *** cases diagnosed as MEC were classified into four variants:classic,oncocytic,Warthin-like,and nonclassified,and they were graded using the Brandwein *** histological characteristics of non-MECs were summarized for differential *** survival analysis was performed on ***:There were 16 MECs;62.5%were MAML2 *** the low-,intermediate-,and high-grade MECs,the rate of rearrangement was 83.3%,100%,and 28.6%,*** the oncocytic and Warthinlike MECs were MAML2 *** the classic and nonclassified MECs without MAML2 rearrangement,non-keratinized squamoid cells and distinctive mucinous cells were essential diagnostic *** survival analysis,all the disease progression occurred in high-grade MECs(p=0.038).Nine cases were diagnosed as non-MECs:pleomorphic adenoma with mucinous metaplasia showed no ex-capsular involvement;metaplastic Warthin tumor appeared with overt keratinization and residual oncocytic bilayered epithelium;mix squamous cell and glandular papilloma showed an endobronchial papillary growing pattern;adenosquamous carcinoma was accompanied by squamous carcinoma in situ of the overlying *** the non-MECs were negative for MAML2 ***:The application of combining MAML2 rearrangement and histological characteristics is helpful in the differential diagnosis between MEC and other tumors with mucinous components.

关键词： differential diagnosis histology MAML2 rearrangement mucinous feature mucoepidermoid carcinoma

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Diagnostic performance of texture analysis in the differential diagnosis of perianal fistulising Crohn’s disease and glandular anal fistula

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 882-891页

作者： Xin Zhu Dan-Dan Ye Jian-Hua Wang Jing Li Shao-Wei Liu Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Radiology Quanzhou Orthopedic-Traumatological HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Perianal fistulising Crohn's disease(PFCD)and glandular anal fistula have many similarities on conventional magnetic resonance ***,many patients with PFCD show concomitant active proctitis,but only few patients with glandular anal fistula have active *** To explore the value of differential diagnosis of PFCD and glandular anal fistula by comparing the textural feature parameters of the rectum and anal canal in fat suppression T2-weighted imaging(FS-T2WI).METHODS Patients with rectal water sac implantation were screened from the first part of this study(48 patients with PFCD and 22 patients with glandular anal fistula).Open-source software ITK-SNAP(Version 3.6.0,http://***/)was used to delineate the region of interest(ROI)of the entire rectum and anal canal wall on every axial section,and then the ROIs were input in the Analysis Kit software(version V3.0.0.R,GE Healthcare)to calculate the textural feature *** feature parameter differences of the rectum and anal canal wall between the PFCD group vs the glandular anal fistula group were analyzed using Mann-Whitney U *** redundant textural parameters were screened by bivariate Spearman correlation analysis,and binary logistic regression analysis was used to establish the model of textural feature ***,diagnostic accuracy was assessed by receiver operating characteristic-area under the curve(AUC)*** In all,385 textural parameters were obtained,including 37 parameters with statistically significant differences between the PFCD and glandular anal fistula ***,16 texture feature parameters remained after bivariate Spearman correlation analysis,including one histogram parameter(Histogram energy);four grey level co-occurrence matrix(GLCM)parameters(GLCM energy_all direction_offset1_SD,GLCM entropy_all direction_offset4_SD,GLCM entropy_all direction_offset7_SD,and Haralick correlation_all direction_offset7_SD);four texture param

关键词： Anal fistula Crohn’s diseases Magnetic resonance imaging Texture analysis differential diagnosis

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Adjustment for the Age-and Gender-Related Metabolic Changes Improves the differential diagnosis of Parkinsonism

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Phenomics 2023年第1期3卷 50-63页

作者： Jiaying Lu Min Wang Ping Wu Igor Yakushev Huiwei Zhang Sibylle Ziegler Jiehui Jiang Stefan Förster Jian Wang Markus Schwaiger Axel Rominger Sung-Cheng Huang Fengtao Liu Chuantao Zuo Kuangyu Shi Department of Nuclear Medicine and PET Center Huashan HospitalFudan University518 East Wuzhong RoadShanghai 200235China Department of Nuclear Medicine InselspitalBern University HospitalUniversity of Bern3010 BernSwitzerland Institute of Biomedical Engineering School of Life SciencesShanghai UniversityShanghai 200444China Department of Informatics Technische Universität München80333 MunichGermany National Research Center for Aging and Medicine and National Center for Neurological Disorders Huashan HospitalFudan UniversityShanghai 200040China Department of Nuclear Medicine Technische Universität München80333 MunichGermany Department of Nuclear Medicine University Hospital LMU Munich80539 MunichGermany Department of Nuclear Medicine Klinikum Bayreuth95445 BayreuthGermany Department of Neurology Huashan HospitalFudan University12 Middle Wulumuqi RoadShanghai 200040China Klinikum r.d.Isar Technische Universität München95445 MunichGermany Department of Molecular and Medical Pharmacology David Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA Human Phenome Institute Fudan UniversityShanghai 200433China

Age and gender are the important factors for brain metabolic declines in both normal aging and neurodegeneration,and the confounding effects may influence early and differential diagnosis of neurodegenerative diseases based on the[^(18)F]fluorodeoxyglucose positron emission tomography([^(18)F]FDG PET).We aimed to explore the potential of the adjustment of age-and gender-related confounding factors on[^(18)F]FDG PET images in differentiation of Parkinson’s disease(PD),multiple system atrophy(MSA)and progressive supra-nuclear palsy(PSP).Eight hundred and seventy-seven clinically definitely diagnosed Parkinsonian patients from a benchmark Huashan Parkinsonian PET imaging database were *** age-and gender-adjusted Z(AGAZ)score was established based on the gender-specific longitudinal metabolic changes on healthy *** scores and standardized uptake value ratio(SUVR)values were quantified at regional-level and support vector machine-based error-correcting output codes method was applied for *** references of the classifications based on metabolic pattern scores were *** feature-based AGAZ score showed the best performance in classification(accuracy for PD,MSA,PSP:93.1%,96.3%,94.8%).In both genders,the AGAZ score con-sistently achieved the best efficiency,and the improvements compared to the conventional SUVR value for PD,MSA,and PSP mainly laid in specificity(Male:5.7%;Female:11.1%),sensitivity(Male:7.2%;Female:7.3%),and sensitivity(Male:7.3%;Female:17.2%).Female patients benefited more from the adjustment on[^(18)F]FDG PET in MSA and PSP groups(absolute net reclassification index,pdifferential diagnosis of ***,the diagnosis of female Parkinsonian population has the best improvement from this correction.

关键词： Age-and gender-adjustment [^(18)F]FDG PET differential diagnosis Parkinsonism

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differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review

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World Journal of Gastroenterology 2020年第30期26卷 4537-4556页

作者： Mohid S Khan Thomas Walter Amy Buchanan-Hughes Emma Worthington Lucie Keeber Marion Feuilly Enrique Grande Department of Gastroenterology and Neuroendocrine Tumours University Hospital of WalesCardiff CF144XWUnited Kingdom Department d'Oncologie Médicale Hospices Civils de LyonLyon 69003France Evidence Development Costello MedicalCambridge CB12JHUnited Kingdom Medical Affairs IpsenSlough SL13XEUnited Kingdom Health Economics and Outcomes Research IpsenBoulogne-Billancourt 92100France Oncology Department MD Anderson Cancer CenterMadrid 28033Spain

BACKGROUND Approximately 20%of patients with neuroendocrine tumours(NETs)develop carcinoid syndrome(CS),characterised by flushing and *** analogues or telotristat can be used to control symptoms of CS through inhibition of serotonin *** CS is often the cause of diarrhoea among patients with gastroenteropancreatic NETs(GEP-NETs),other causes to consider include pancreatic enzyme insufficiency(PEI),bile acid malabsorption and small intestinal bacterial *** other causes of diarrhoea unrelated to serotonin secretion are mistaken for CS diarrhoea,these treatments may be ineffective against the diarrhoea,risking detrimental effects to patient quality of *** To identify and synthesise qualitative and quantitative evidence relating to the differential diagnosis of diarrhoea in patients with *** Electronic databases(MEDLINE,Embase and the Cochrane Library)were searched from inception to September 12,2018 using terms for NETs and ***,systematic literature review bibliographies and included articles were also *** study designs and publication types were eligible for inclusion if relevant data on a cause(s)of diarrhoea in patients with GEP-NETs were *** were screened by two independent reviewers at abstract and full-text *** synthesis was adapted to synthesise quantitative and qualitative *** definition of qualitative data was expanded to include all textual data in any section of relevant *** Forty-seven publications(44 studies)were included,comprising a variety of publication types,including observational studies,reviews,guidelines,case reports,interventional studies,and opinion *** reported on PEI on/after treatment with somatostatin analogs;9.5%-84%of patients with GEP-NETs had experienced steatorrhoea or confirmed *** reported,14.3%–50.7%of patients received pancreatic enzyme replacement *** causes of diarrhoea

关键词： Carcinoid syndrome Diarrhea differential diagnosis Neuroendocrine tumours Serotonin Systematic review

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