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Passively and actively enhanced surface plasmon resonance sensing strategies towards single molecular detection

Nano Research 2022年第9期15卷 8367-8388页

作者： Boliang Jia Jiajie Chen Jie Zhou Youjun Zeng Ho-Pui Ho Yonghong Shao Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronics EngineeringShenzhen UniversityShenzhen 518060China School of Physics&Optoelectronic Engineering Guangdong University of TechnologyGuangzhou 510006China Department of Biomedical Engineering The Chinese University of Hong KongShatin 999077Hong KongChina

Surface plasmonic resonance(SPR)has been a corner stone for approaching single molecular detection due to its highsensitivity capability and simple detection mechanism,and has brought major advancements in biomedicine and life science *** decades,the successful integration of SPR with versatile techniques has been ***,several crucial limitations have hindered this technique for practical applications,such as long detection time and low overall *** review aims to provide a comprehensive summary of existing approaches in enhancing the performance of SPR sensors based on“passive”and“active”***,passive enhancement is discussed from a material aspect,including signal amplification tags and modifications of conventional ***,the focus is on the most popular active enhancement methods including electrokinetic,optical,magnetic,and acoustic manipulations that are summarized with highlights on their advantageous features and ability to concentrate target molecules at the detection ***,prospects and future development directions for developing SPR sensing towards a more practical,single molecular detection technique in the next generation are *** review hopes to inspire researchers’interests in developing SPR-related technology with more innovative and influential ideas.

关键词： surface plasmon resonance single molecular detection plasmonic materials nanotweezers(NTs) dielectrophoresis trap

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