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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 59-64页

作者： Bibek Poudel Binod Kumar Yadav Arun Kumar Bharat Jha Kanak Bahadur Raut Department of Biochemistry Manipal College of Medical Sciences(MCOMS)Manipal Teaching Hospital(MTH) Research Institute of Clinical Medicine Chonbuk National University Medical School and Hospital Department of Biochemistry Institute of MedicineTribhuvan University Teaching Hospital(Institute of MedicineTUTH) Department of Internal.Medicine Institute of MedicineTribhuvan University Teaching Hospital(Institute of MedicineTUTH)

Objective:To develop the missing link between hyperuricemia and ***:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine *** was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National *** 205newly diagnosed and untreated essential hypertensive cases and age-sex matched nonnotensive controls were enrolled in the *** potential confounding factors of hyperuricemia and hypertension in both cases and controls were *** acid levels in all participants were ***:Renal function between newly diagnosed hypertensive cases and nonnotensive healthy controls were *** mean serum uric acid observed in newly diagnosed hypertensive cases and in nonnotensive healthy controls were(290.05±87.03)μmol/L and(245.24±09.38)μmol/L respectively.A total of 59(28.8%)participants of cases and 28(13.7%)participants of controls had hyperuricemia(odds ratio 2.555(95%CI:1.549-4.213),P<0.00l).Conclusions:The mean serum uric acid leveb and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.

关键词： Newly diagnosed hypertension Serum uric acid Hyperuricemia Joint National Committee

A case of hepatocellular carcinoma diagnosed as facial cutaneous metastasis survives for 18 months

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Chinese Medical Journal 2019年第5期132卷 616-617页

作者： Jing-Xin Zeng Xin Tian Hui-Lan Zhu Xi-Bao Zhang Quan Luo Institute of Dermatology Guangzhou Medical UniversityGuangzhouGuangdong 510095China

To the Editor: Cutaneous metastasis of an internal malignancy is uncommon. Its clinical presentation is variable, although it is rarely seen in hepatocellular carcinoma (HCC).[1] For patients with HCC, the presence of... 详细信息

关键词： hepatocellular carcinoma diagnosed facial cutaneous metastasis survives internal malignancy

Correlation between Subliminal Depression and the Quality of Life in Patients Preliminarily diagnosed with Breast Cancer

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Yangtze Medicine 2019年第1期3卷 10-18页

作者： Jianjian Chen Hong Wang Haiyuan Zhang Juan Ding School of Medicine Yangtze University Jing Zhou China Second Clinical Medicine School of Yangtze University Breast Department of Jingzhou Central Hospital Jing Zhou China

Objective: To investigate the subthreshold depression and the quality of life in patients preliminarily diagnosed with breast cancer, and to explore their relationship. Methods: A total of 210 patients preliminarily diagnosed breast cancer were recruited by convenience sampling method to complete the self-made general questionnaire, Center for Epidemiological Studies Depression Scale (CES-D), Hamilton Rating Scale for Depression and Functional Assessment of Cancer Therapy-Breast (FACT-B). Results: The incidence rates of subthreshold depression was 48.6% in patients preliminarily diagnosed breast cancer, the total score of FACT-B in patients with subthreshold depression and non-subthreshold depression was (73.92 ±17.62) and (86.74 ±16.15). The total score of CES-D was significantly negatively correlated to the total score and factor scores of FACT-B (p Conclusion: The incidence rate of subthreshold depression in preliminarily diagnosed breast cancer patients is high, and it is closely related to the quality of life, so we should pay attention to the psychological status of preliminarily diagnosed breast cancer patients, to increase the psychological intervention, than improve their quality of life.

关键词： Patients Preliminarily diagnosed Breast Cancer Subthreshold Depression Quality of Life

Relationship between plasma adipokines, inflammation, insulin resistance and subclinical atherosclerosis in newly diagnosed type 2 diabetes

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Journal of Diabetes Mellitus 2011年第2期1卷 17-25页

作者： Razvan Vasilescu Silvi Ifrim Constantin Ionescu-Tirgoviste 不详

Background: The aim of this study was to investigate the occurrence of subclinical atherosclerosis, evaluated by carotid artery intima-media thickness (CIMT) in subjects with newly diagnosed type 2 diabetes. Methods: A total of 167 subjects, 50 newly diagnosed type 2 diabetic subjects and 117 non-diabetic subjects were included in the study. Obese and overweight newly diagnosed type 2 diabetic patients were matched for age and BMI with obese and overweight non-diabetic subjects. Only postmenopausal women were selected. The following biomarkers were analyzed: fasting glucose, HbA1c, fasting insulin, fasting proinsulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, adiponectin, leptin, hs-CRP, urine albumin/creatinine ratio. 75 g oral glucose tolerance test was performed in all subjects. Ultrasound imaging was used to evaluate IMT of the common carotid artery. Results: CIMT was greater in newly diagnosed type 2 patients compared to non-diabetic subjects. When analyzed by BMI, the difference regarding CIMT between diabetic and non-diabetic subjects was significant only in overweight subjects, in both sexes. In univariate analysis in men with newly diagnosed type 2 diabetes, CIMT was positively correlated with age, SBP, triglycerides, leptin and negatively correlated with HDL-cholesterol and in women CIMT was positively correlated with SBP and leptin. Independent determinants of CIMT in patients with newly diagnosed type 2 diabetes were in men age (β = 0.556, p = 0.0028) and log leptin (β = 0.393, p = 0.049) and in women systolic blood pressure (β = 0.48, p = 0.026). Conclusions: Subclinical atherosclerosis is present in newly diagnosed type 2 diabetic subjects. Body fat accumulation in men and hypertension in postmenopausal women have a primary role in increase carotid intima-media thickness.

关键词： Newly diagnosed Type 2 Diabetes Atheroscleorsis Common Carotid Artery Intima-Media Thickness

Expression of CD45 in newly diagnosed multiple myeloma and the relationship with prognosis

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China Medical Abstracts(Internal Medicine) 2019年第4期36卷 229-230页

作者： SHI Jie Henan Prov People's Hosp Zhengzhou 450003

Objective To explore the expression of CD45 in newly diagnosed multiple myeloma(MM)and its relationship with clinical efficacy and *** This study retrospectively analyzed expression and distribution of CD45 in 130 cas... 详细信息

关键词： Expression CD45 diagnosed

Intra-thyroid esophageal duplication cyst:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2231-2236页

作者： Hong-Guo Lin Ming Liu Xue-Yang Huang Da-Sheng Liu Department of Vascular Thyroid Surgery The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Esophageal cysts are relatively rare in clinical practice,with most of the literature comprising case *** cysts protruding into the thyroid gland are easily misdiagnosed as thyroid *** such cases have been reported so *** SUMMARY This article reports the case of a 31-year-old adult male diagnosed with thyroid nodules before *** patient underwent left thyroidectomy and *** the surgery,esophageal cysts were identified in the esophageal muscle and thyroid *** pathology results confirmed a nodular goiter combined with esophageal ***,the patient developed a neck infection and underwent another operation and broad-spectrum antibiotic treatment for *** We report the first clinical case of an esophageal cyst located within the thyroid gland that was successfully treated *** cyst located within the thyroid gland cause difficulties in *** the present study,the contents of the esophageal cysts were calcified foci,and a small amount of fluid mixture,which were easily misdiagnosed as thyroid nodules and misled the surgical methods.

关键词： Esophageal cysts Thyroid diagnosed Surgery Case report

Mother and daughter became father and son： a case report

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Asian Journal of Andrology 2015年第5期17卷 855-856页

作者： Tatjana Sajevets Charlotte Verroken Gunter Heylens Elfride De Baere Guy T'Sjoen Department of Endocrinology Ghent University Hospital Ghent 9000 Belgium Department of Sexology and Gender Problems Ghent University HospitalGhent 9000 Belgium Centre for Medical Genetics Ghent University HospitalGhent 9000 Belgium

Dear Editor, Gender dysphoria （GD） is defined as a marked incongruence between one＇s experienced and one＇s assigned gender. It is characterized by a strong desire to get rid of one＇s primary and/or secondary sex characteristics and to have the primary and/or secondary sex characteristics of the other gender. Here, we present a case of a mother and daughter who were both diagnosed with GD.

关键词： daughter father diagnosed

Thyroid autoimmunity at the onset of type 1 diabetes mellitus in children

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Open Journal of Immunology 2013年第1期3卷 37-40页

作者： Siamak Shiva Farzad Ilkhchooyi Azim Rezamand Pediatric Health Research Center Tabriz University of Medical Sciences Tabriz Iran Tabriz University of Medical Sciences Tabriz Iran

Introduction: Studies that have investigated autoimmune thyroid disease in newly diagnosed type 1 diabetic children are few and reported prevalence rate ranges between 4.5 - 29.4 percent. Considering the effect of age, ethnic origin, and disease duration on the prevalence of autoimmune thyroid disease in diabetic subjects, we decided to investigate the thyroid autoimmunity in newly diagnosed type 1 diabetic children in our area of residence (North-WestIran). Methods: This cross-sectional study was carried out between 2008 and 2010. All of the children with newly diagnosed type 1 diabetes mellitus (T1DM) presenting to the outpatient pediatric- endocrinology clinic of Tabriz University of Medical Sciences (the only university-affiliated clinic for pediatric-endocrinology in North-west Iran), were investigated for serum levels of anti- TPO, anti-Tg and TSH. Results: The study group included 99 children [mean age 7.75 ± 3.21 years (range 1.2 - 14), 45 boys (45.5%) and 54 girls (54.5%)]. About 9% of patients were seropositive for anti thyroid antibodies and females were affected more than males. The mean TSH level of subjects above 12 years of age (3.5 ± 2) was significantly (p = 0.037) higher than those below this age. Conclusion: Autoimmune thyroid disease and even hypothyroidism may accompany T1DM at its presenting time in children. This finding is more common in girls especially those above 12 years of age.

关键词： Newly diagnosed Diabetes Autoimmune Thyroid Disease Children

Expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia and its prognostic significance

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China Medical Abstracts(Internal Medicine) 2018年第4期35卷 232-233页

作者： CHEN Hao Dept Hematol Affil Cancer HospZhengzhou Univ

Objective To detect the expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia(B-ALL)in newly diagnosed cases,and to investigate the relationship between CRLF2 and the general clinical characteristics,efficacy and *** 103 cases of newly diagnosed adult B-ALL patients were investigated from Apr 2016 to Dec 2017 in the Department of Hematology,Henan Cancer *** marrow samples were used to detect the expression of CRLF2 in leukemic *** expression of CRLF2≥20% was defined as CRLF2-high group and<20% was defined as CRLF2-low *** clinical characteristics and prognosis of the two groups were *** The Median overall survival(OS)and disease free survial(DFS)in CRLF2-high group were 9.0 months and 4.25 months,***2-low group was 15.5 months and 10.25 months,*** was a statistically significant difference in median OS and DFS between the two groups(P=0.007,P=0.000).The 18-month OS and DFS in CRLF2-high group were 38.6% and 25.1%,***2-low group was 57.8% and 42.3%,*** analysis showed high expression of CRLF2 was an independent risk factor for OS(HR=2.991,95% CI 1.429-6.261,P=0.004)and DFS(HR=2.374,95% CI 1.146-4.960,P=0.041)in *** Patients with high expression of CRLF2 have poor prognosis.

关键词： the relationship newly diagnosed cases

Euthyrox Induced Drug Rash in an Aged Patient

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Chinese Medical Journal 2015年第22期128卷 3120-3120页

作者： Rui Tang Jun Liu Shi Chen Department of Allergy Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Endocrinology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Ministry of Health Key Laboratory of Endocrinology Beijing 100730 China

To the Editor： A 65-year-old woman was admitted to Peking Union Medical College Hospital because of rash with pruritus for 1 month after taking Euthyrox. Rash attacked without other symptoms 20 days after she took Euthyrox 50 μg once a day and aggravated when Euthyrox was continued for the next 2 days. The past history included partial thyroidectomy for hyperthyroidism in 1982; tuberculosis in 1990; hypertension in 2009, and cerebral hemorrhage in 2010.

关键词： induced diagnosed Euthyrox