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Mechanistic insights into the amelioration effects of diabetic cardiomyopathy by berberine:an integrated systems pharmacology study and experimental validation

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Traditional Medicine Research 2025年第3期10卷 42-55页

作者： Hui-Min Ji Wen Yang Yu Hua Yi-Xuan Sun Ao-Di Li Yue Jiang Zi-Qi Ye Min Lei Xi-Ying Guo Xiu-Fen Liu Ning-Hua Wu Huan-Bo Cheng Qing-Jie Chen School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Hubei Key Laboratory of Diabetes and Angiopathy Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China School of Basic medical Sciences Medicine Research InstituteXianning Medical CollegeHubei University of Science and TechnologyXianning 437100China Jin License Holding Zhengtang Pharmaceutical Co. Ltd.Huangshi 435100China

Background:diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart ***(BBR),a quaternary ammonium alkaloid isolated from Coptidis Rhizoma,a traditional Chinese medicine,has superior anti-diabetic and heart-protective *** purpose of this study is to assess the impact of BBR on ***:This study used a systems pharmacology approach to evaluate the related proteins and signalling pathways between BBR and DCM targets,combined with experimental validation using diabetic mouse heart *** and pathological changes were observed using Hematoxylin-eosin,Masson’s trichrome stain and wheat germ agglutinin *** and western blot were used to determine protein ***:The results indicate that BBR and DCM share 21 core relevant targets,with cross-targets predominantly located in mitochondrial,endoplasmic reticulum,and plasma membrane *** exerts its main effects in improving DCM by maintaining mitochondrial integrity,particularly involving the PI3K-AKT-GSK3βand apoptosis signalling *** addition,post-treatment changes in the key targets of BBR,including cysteine aspartate specific protease(Caspase)-3,phosphoinositide 3-kinase(PI3K)and mitochondria-related proteins,are suggestive of its ***:BBR crucially improves DCM by maintaining mitochondrial integrity,inhibiting apoptosis,and modulating PI3K-AKT-GSK3β*** studies must address animal model limitations and validate clinical efficacy to understand BBR’s mechanisms fully and its potential clinical use.

关键词： berberine apoptosis integrated systems pharmacology diabetic cardiomyopathy

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diabetic cardiomyopathy:Emerging therapeutic options

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World Journal of Diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius James Fernandez Sahana Shetty Joseph M Pappachan Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

diabetic cardiomyopathy(DbCM)is a common but underrecognized complication of patients with diabetes mellitus(DM).Although the pathobiology of other cardiac complications of diabetes such as ischemic heart disease and cardiac autonomic neuropathy are mostly known with reasonable therapeutic options,the mechanisms and management options for DbCM are still not fully *** its early stages,DbCM presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from prompt control of DM with lifestyle changes and antidiabetic medications,disease-modifying therapy for DbCM includes prompt control of hypertension and dyslipidemia inherent to patients with DM as in other forms of heart diseases and the use of treatments with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of Diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic mouse models with *** this preliminary basic study might help to improve our understanding of DbCM and offer a potential new management option for patients with the disease,the positive results from such animal models might not always translate to clinical practice as the pathobiology of DbCM in humans could be ***,such experimental studies can encourage more scientific efforts to find a better solution to treat patients with this enigmatic disease.

关键词： diabetic cardiomyopathy diabetic cardiomyopathy Heart failure Pathobiology Teneligliptin

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diabetic cardiomyopathy:Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis

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World Journal of Diabetes 2024年第8期15卷 1659-1662页

作者： Lu Cai Yi Tan Md Shahidul Islam Michael Horowitz Kupper A Wintergerst Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Department of Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute Division of EndocrinologyDepartment of PediatricsWendy Novak Diabetes InstituteNorton Children’s HospitalUniversity of LouisvilleLouisvilleKY 40202United States

Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively ***,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and associated pyroptosis in the heart of type 1 or type 2 diabetic rodent models,and whether various medications and natural products prevent the development of DCM,associated with decreased levels of cardiac NLRP3 inflammasome and *** direct link of NLRP3 inflammasome and associated pyroptosis to the pathogenesis of DCM remains unclear based on the limited evidence derived from the available studies,with the approaches of NLRP3 gene silencing or pharmaceutical application of NLRP3 specific *** thus emphasize the requirement for more systematic studies that are designed to provide direct evidence to support the link,given that several studies have provided both direct and indirect evidence under specific *** editorial emphasizes that the current investigation should be circumspect in its conclusion,i.e.,not overemphasizing its role in the pathogenesis of DCM with the fact of only significantly increased expression or activation of NLRP3 inflammasome and pyroptosis in the heart of diabetic rodent *** clear-cut evidence-based causative roles of NLRP3 inflammasome and pyroptosis in the pathogenesis of DCM can help to develop effective and safe medications for the clinical management of DCM,targeting these biomarkers.

关键词： diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death Pyroptosis

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Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1496-1509页

作者： Yanhua Liu Xin Zhang Shu Yang Zhi Zhou Lu Tian Wanfang Li Jinfeng Wei Zeper Abliz Zhonghua Wang Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) National Ethnic Affairs CommissionBeijing100081China Center for Imaging and Systems Biology College of Life and Environmental SciencesMinzu University of ChinaBeijing100081China New Drug Safety Evaluation Center Institute of Materia MedicaPeking Union Medical CollegeBeijing100050China Key Laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing100081China

diabetic cardiomyopathy(DCM)is a metabolic disease and a leading cause of heart failure among people with *** spectrometry imaging(MSI)is a versatile technique capable of combining the molecular specificity of mass spectrometry(MS)with the spatial information of *** this study,we used MSI to visualize metabolites in the rat heart with high spatial resolution and *** optimized the air flow-assisted desorption electrospray ionization(AFADESI)-MSI platform to detect a wide range of metabolites,and then used matrix-assisted laser desorption ionization(MALDI)-MSI for increasing metabolic coverage and improving localization ***-MSI detected 214 and 149 metabolites in positive and negative analyses of rat heart sections,respectively,while MALDI-MSI detected 61 metabolites in negative *** study revealed the heterogenous metabolic profile of the heart in a DCM model,with over 105 region-specific changes in the levels of a wide range of metabolite classes,including carbohydrates,amino acids,nucleotides,and their derivatives,fatty acids,glycerol phospholipids,carnitines,and metal *** repeated oral administration of ferulic acid during 20 weeks significantly improved most of the metabolic disorders in the DCM *** findings provide novel insights into the molecular mechanisms underlying DCM and the potential of ferulic acid as a therapeutic agent for treating this condition.

关键词： Mass spectrometry imaging diabetic cardiomyopathy Metabolic reprogramming Ferulic acid

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Hyperglycemic memory in diabetic cardiomyopathy

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Frontiers of Medicine 2022年第1期16卷 25-38页

作者： Jiabing Zhan Chen Chen Dao Wen Wang Huaping Li Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China

Cardiovascular diseases account for approximately 80%of deaths among individuals with diabetes mellitus,with diabetic cardiomyopathy as the major diabetic cardiovascular *** is a symptom that abnormally activates multiple downstream pathways and contributes to cardiac hypertrophy,fibrosis,apoptosis,and other pathophysiological *** glycemic control has long been at the center of diabetes therapy,multicenter randomized clinical studies have revealed that intensive glycemic control fails to reduce heart failure-associated hospitalization and mortality in patients with *** finding indicates that hyperglycemic stress persists in the cardiovascular system of patients with diabetes even if blood glucose level is tightly controlled to the normal *** process is now referred to as hyperglycemic memory(HGM)*** briefly reviewed herein the current advances that have been achieved in research on the underlying mechanisms of HGM in diabetic cardiomyopathy.

关键词： diabetes diabetic cardiomyopathy hyperglycemic memory

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LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy

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Science China(Life Sciences) 2022年第6期65卷 1198-1212页

作者： Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang Department of Pharmacology State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular Medicine ResearchMinistry of EducationCollege of PharmacyHarbin Medical UniversityHarbin 150081China College of Pharmacy Qiqihar Medical UniversityQiqihar 161006China Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zone(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China

diabetic cardiomyopathy(DCM)is a common complication in diabetic *** molecular mechanisms of DCM remain to be fully *** intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac *** this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular *** expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated *** of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM *** of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high *** DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse *** addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in *** summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse *** of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy.

关键词： diabetic cardiomyopathy apoptosis oxidative stress lncRNA SIRT3

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Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy

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Military Medical Research 2024年第5期11卷 625-642页

作者： Meng-Yuan Jiang Wan-Rong Man Xue-Bin Zhang Xiao-Hua Zhang Yu Duan Jie Lin Yan Zhang Yang Cao De-Xi Wu Xiao-Fei Shu Lei Xin Hao Wang Xiao Zhang Cong-Ye Li Xiao-Ming Gu Xuan Zhang Dong-Dong Sun Department of Cardiology Xijing HospitalAir Force Medical UniversityXi’an710032China Department of Basic Medicine Air Force Medical UniversityXi’an710032China Department of Physiology and Pathophysiology Air Force Medical UniversityXi’an710032China Institute for Hospital Management Research Chinese PLA General HospitalBeijing100853China

Background diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, which impairs myocardial function. Adipsin may play an important protective role in the pathogenesis of DCM. The aim of this study is to investigate the regulatory effect of Adipsin on DCM lipotoxicity and its molecular *** high-fat diet (HFD)-induced type 2 diabetes mellitus model was constructed in mice with adipose tissue-specific overexpression of Adipsin (Adipsin-Tg). Liquid chromatography-tandem mass spectrometry (LC–MS/MS), glutathione-S-transferase (GST) pull-down technique, Co-immunoprecipitation (Co-IP) and immunofluorescence colocalization analyses were used to investigate the molecules which can directly interact with Adipsin. The immunocolloidal gold method was also used to detect the interaction between Adipsin and its downstream *** expression of Adipsin was significantly downregulated in the HFD-induced DCM model (P diabetic stress (P < 0.05). LC–MS/MS analysis, GST pull-down technique and Co-IP studies revealed that interleukin-1 receptor-associated kinase-like 2 (Irak2) was a downstream regulator of Adipsin. Immunofluorescence analysis also revealed that Adipsin was co-localized with Irak2 in cardiomyocytes. Immunocolloidal gold electron microscopy and Western blotting analysis indicated that Adipsin inhibited the mitochondrial translocation of Irak2 in DCM, thus dampening the interaction between Irak2 and prohibitin (Phb)-optic atrophy protein 1 (Opa1) on mitochondria and improving the structural integrity and function of mitochondria (P < 0.05). Interestingly, in

关键词： diabetic cardiomyopathy Mitochondrial translocation Mitochondrial function Fatty acidβ-oxidation

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Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

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Acta Pharmaceutica Sinica B 2022年第2期12卷 708-722页

作者： Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai Pediatric Research Institute Department of PediatricsUniversity of Louisville School of MedicineLouisvilleKY 40202USA Department of Cardiovascular Disease the First Hospital of Jilin UniversityChangchun 130021China Department of Burn Surgery First Hospital of Jilin UniversityJilin UniversityChangchun 130021China Department of Pharmacology and Toxicology University of Louisville School of MedicineLouisvilleKY 40202USA Pediatric Heart Research Program Cardiovascular Innovation InstituteUniversity of Louisville School of MedicineLouisvilleKY 40202USA Cincinnati Children’s Heart Institute Greater Louisville and Western Kentucky PracticeLouisvilleKY 40202USA

Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM *** glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 *** morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron *** of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and *** was also evidenced in the heart of type 2 diabetic mice with *** of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of *** factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 *** protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-*** findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 *** suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM.

关键词： Advanced glycation end-products AMPK Cell death diabetic cardiomyopathy Engineered cardiac tissue Ferroptosis Lipid peroxidation NRF2

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Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy ——a hypothesis

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1041-1045页

作者： Kaviyarasi Renu V.G.Abilash P.B.Tirupathi Pichiah Thabassum Akthar Syeda Sankarganesh Arunachalam School of Biosciences and Technology VIT University Department of Animal Science School of Life Sciences Bharathidasan University Department of Biotechnology Kalasalingam University

diabetic cardiomyopathy is one of the life threatening complications of diabetes. A number of animal models are being used for studying diabetic cardiomyopathy. In laboratory animal models, induction of cardiomyopathy happens in two stages: first being the induction of diabetic condition and the second being the induction of cardiomyopathy by prolonging diabetic condition. It takes a longer time to develop diabetes with the limited success rate for development of cardiomyopathy. Adriamycin is an effective anticancer drug limited by its major side-effect cardiomyopathy. A number of features of Adriamycin treatment mimics diabetes. We postulate that Adriamycin-induced cardiomyopathy might be used as a model system to study diabetic cardiomyopathy in rodents since a number of features of both the cardiomyopathies overlap. Left ventricular hypertrophy, systolic and diastolic dysfunction, myofibrillar loss, and fibrosis are hallmarks of both of the cardiomyopathies. At the molecular level, calcium signaling, endoplasmic reticulum stress, advance glycation endproduct activation, mitochondrial dysfunction,inflammation, lipotoxicity and oxidative stress are similar in both the *** signature profile of both the cardiomyopathies shares commonalities. In conclusion,we suggest that Adriamycin induced cardiomyopathic animal model can be used for studying diabetic cardiomyopathy and would save time for researchers working on cardiomyopathy developed in rodent using the traditional method.

关键词： cardiomyopathy Diabetes Animal model for cardiomyopathy Adriamycin diabetic cardiomyopathy

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Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome

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World Journal of Diabetes 2024年第4期15卷 724-734页

作者： Gu-Lao Zhang Yuan Liu Yan-Feng Liu Xian-Tao Huang Yu Tao Zhen-Huan Chen Heng-Li Lai Department of Cardiology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330000Jiangxi ProvinceChina

BACKGROUND diabetic cardiomyopathy(DCM),which is a complication of diabetes,poses a great threat to public *** studies have confirmed the role of NLRP3(NOD-like receptor protein 3)activation in DCM development through the inflammatory *** is an oral hypoglycemic dipeptidyl peptidase-IV inhibitor used to treat *** has recently been reported to have anti-inflammatory and protective effects on myocardial *** To examine the therapeutic effects of teneligliptin on DCM in diabetic *** Streptozotocin was administered to induce diabetes in mice,followed by treatment with 30 mg/kg *** Marked increases in cardiomyocyte area and cardiac hypertrophy indicator heart weight/tibia length reductions in fractional shortening,ejection fraction,and heart rate;increases in creatine kinase-MB(CK-MB),aspartate transaminase(AST),and lactate dehydrogenase(LDH)levels;and upregulated NADPH oxidase 4 were observed in diabetic mice,all of which were significantly reversed by ***,NLRP3 inflammasome activation and increased release of interleukin-1βin diabetic mice were inhibited by *** mouse cardiomyocytes were treated with high glucose(30 mmol/L)with or without teneligliptin(2.5 or 5μM)for 24 ***3 inflammasome *** in CKMB,AST,and LDH levels in glucose-stimulated cardiomyocytes were markedly inhibited by teneligliptin,and AMP(p-adenosine 5‘-monophosphate)-p-AMPK(activated protein kinase)levels were ***,the beneficial effects of teneligliptin on hyperglycaemia-induced cardiomyocytes were abolished by the AMPK signaling inhibitor compound *** Overall,teneligliptin mitigated DCM by mitigating activation of the NLRP3 inflammasome.

关键词： diabetic cardiomyopathy Teneligliptin NLRP3 AMPK Interleukin-1β

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