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Inhibition of Aloperine on dextran sulphate sodium-induced Chronic Colitis in C57BL/6 Mice

Chinese Herbal Medicines 2012年第3期4卷 218-223页

作者： SONG Li-jun 1 , ZHAO Wen-chang 1 , DENG Hong-zhu 2 1. School of Pharmacy, Guangdong Medical College, Dongguan 523808, China 2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China School of Pharmacy Guangdong Medical College Dongguan 523808 China School of Traditional Chinese Medicine Southern Medical University Guangzhou 510515 China

Objective To investigate the effects of aloperine (ALO) on a model of dextran sulphate sodium (DSS)-induced chronic colitis in C57BL/6 mice. Methods Repeated colitis was induced by administration of four cycles of 4% DSS. The severity of colitis was assessed on the basis of clinical signs, ratio of colon weight and colon length, and histological grading scores. Moreover, secretory immunoglobulin A (S-IgA) and plasma haptoglobin (HP) were analyzed by enzyme-linked immunosorbent assay, and the changes of mRNA expression of ICAM-1 and MIF gene in colorectal tissue were detected by quantitative reverse transcriptase real-time polymerase chain reaction using SYBR Green I. Results ALO administration significantly attenuated the colon damage, caused substantial reductions of the rise in HP, and maintained the level of cecum S-IgA. ALO inhibited the ICAM-1 mRNA expression and had no effect on MIF mRNA expression. Conclusion The effect of ALO on DSS-induced chronic colitis in mice is investigated for the first time, which suggests that ALO could be an attractive therapeutic candidate in the treatment of inflammatory bowel disease.

关键词： aloperine dextran sulphate sodium haptoglobin inflammatory bowel disease secretory immunoglobulin A

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Bawei Xileisan attenuates colitis by inhibiting Th17 cytokines,promoting the Th17/Treg balance,and improving Lactobacillus levels

Bawei Xileisan attenuates colitis by inhibiting Th17 cytokin...

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第九届全国免疫学学术大会

作者： Juan Wen Xinjun Chen Yuan Fang Jiadong Ding Chunjiang Zhang Key Laboratory of Cell Activities and Stress Adaptations Ministry of EducationLanzhou University School of Life Science Lanzhou University

Background:The Th17 pathway and the balance between Th17 and Treg cells as novel targets for the treatment of inflammatory bowel disease,have received increasing *** Xileisan is a traditional Chinese medicine,which has been used for many years to clinically treat conditions associated with ulcerative ***,the precise mechanisms behind its anti-inflammatory effects remain largely ***:In this study,by the administration of 3%dextran sulphate sodium(DSS)in a C57BL/6 mouse model,we evaluated the therapeutic effects of Bawei Xileisan(200 or 400 mg/kg)against UC and elucidated the possible underlying molecular *** analyses were used to evaluate Th17 cytokine *** mononuclear cells(SPMNC)were used to evaluate Th17 and Treg cellular *** amounts of Bacteroides and Lactobacillus in the stool were ***:We found that the rectal infusion of Bawei Xileisan(200 or 400 mg/kg)profoundly ameliorated DSS induced clinical manifestations,colon shortening and histological damage in the mice with *** addition Bawei Xileisan significantly reduced the expression of Th17-related cytokines IL-17A,IL-17F,and IL-22,and restored the Th17/Treg ***,Bawei Xileisan treatment improved Lactobacillus levels and demonstrated beneficial effects on ***:Taken together,our findings suggest that the restoration of Th17/Treg balance reducing the expression of inflammation-associated cytokines IL-17A,IL-17F,and IL-22,and improving Lactobacillus levels may be the mechanisms involved in the therapeutic effects of Bawei Xileisan against UC.

关键词： Bawei Xileisan Ulcrative colitis dextran sulphate sodium Th17/Treg pathway Bacteroides Lactobacillus

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