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Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder

Neural Regeneration Research 2021年第3期16卷 537-542页

作者： Xiao-Lie He Li Yang Zhao-Jie Wang Rui-Qi Huang Rong-Rong Zhu Li-Ming Cheng Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Department of OrthopedicsTongji HospitalSchool of Life Science and TechnologyTongji UniversityShanghaiChina

dexanabinol(HU-211)is an artificially synthesized cannabinoid derivative that exerts neuroprotective effects through anti-inflammatory and antioxidant *** exhibits antidepressant effects in the treatment of major depressive *** investigate the antidepressant effects of solid lipid nanoparticles loaded with both curcumin and dexanabinol,and the underlying mechanisms associated with this combination,we established wild-type(CBR1~(+/+))and cannabinoid receptor 1(CBR1)knockout(CBR1~(–/–))mouse models of major depressive disorder,through the intraperitoneal injection of corticosterone,for 3 successive days,followed by treatment with intraperitoneal injections of solid lipid nanoparticles loading with curcumin(20 mg/kg)and dexanabinol(0.85 mg/kg),for 2 successive *** results revealed that solid lipid nanoparticle loading with curcumin and dexanabinol increased the m RNA and protein expression levels of the mature neuronal markers neuronal nuclei,mitogen-activated protein 2,and neuron-specific beta-tubulin III,promoted the release of dopamine and norepinephrine,and increased the m RNA expression of CBR1 and the downstream genes Rasgef1c and Egr1,and simultaneously improved rat locomotor ***,solid lipid nanoparticles loaded with curcumin and dexanabinol had no antidepressant effects on the CBR1~(–/–)mouse models of major depressive *** study was approved by the Institutional Ethics Committee of Tongji Hospital of Tongji University,China(approval No.2017-DW-020)on May 24,2017.

关键词： biocompatibility curcumin depression dexanabinol dopamine nanoparticles norepinephrine

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