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Synthesis of Novel Fluorescence reagents and Their Application in determination of Thiol Compounds

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有机化学 2003年第Z1期23卷 265-265页

作者： LIANG Shu-Cai WANG Hong ZHANG Hua-Shan HU Xian-Ming Colloge of Pharmacy Wuhan University Wuhan 430072 Colloge of Chemistry Wuhan University Wuhan 430072 Colloge of Chemistry Wuhan University Wuhan 430072 Colloge of Pharmacy Wuhan University Wuhan 430072

　　The identification and determination of thiol compounds is essential both for the clinical diagnosis and the con trol of diseases because alteration of their concentrations in biological systems are somehow respon... 详细信息

关键词： myocardial infarction clinical diagnosis biological systems determination of

Kinetic Spectrophotometric Method for determination of Oxalic Acid and Its application in Lathyrus sativus

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有机化学 2003年第Z1期23卷 441-441页

作者： YAN Ze-Yi XING Geng-Mei LI Zhi-Xiao National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 Laboratory of Arid Agroecology Lanzhou University Lanzhou 730000 National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

　　Oxalic acid is one of the most common nutrient chelators in the human diet found in many vegetables, such as mushroom, spinach, fresh kidney beans, rhubarb leaves and beet leaves. Some recent reports demonstrate that oxalate plays an important role in resistance stress metabolism and steady state regulation in plant. [1]……

关键词： Lathyrus sativus Oxalic Acid determination of steady state

Spectrophotometric Method for the determination of Oxidative IonsWith Decoloring Reaction Using HCPCF

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Chemical Research in Chinese Universities 2001年第Z1期17卷 211-页

作者： KOU Zongyan Department of Chemistry Gansu Education College

HCPCF is a color reagent for the determination of vanadium, zinc and magnesium, etc. To the best of our knowledge, no work on the decoloring reaction for analytical use of HCPCF for the determination of oxidative anions has been report. In this work, we found that some oxidative anions can oxidize HCPCF in acid medium, forming a colorless product. In addition, surfactant was used in this work, because of the low solubility of HCPCF in aqueous solutions. The purpose of this work is to establish a new, rapid and simple spectrophotometric method for the determination of NO2-, BrO3-,IO3-, IO4-and Cr2O7-based on the reaction between HCPCF and analytes in the presence of emulsion OP.

关键词： determination of spectrophotometric method used in

SpectrophoStonetric determination of IO4- by Fading Reaction of Chlorophosphonazo-pN with Potassium Periodate

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Chemical Research in Chinese Universities 2001年第Z1期17卷 210-页

作者： LI Xin Department of Chemistry Gansu Education College

2-(4-chloro-2-phosphonophenylazo)-7-(4-nitrophenylazo)-1,8-dihydroxy-3,6-napht-halenedisulfonic acid (Chlorophosphonazo-Pn) has been proposed as a sensitive color reagent for the determination of metal ions by spectro... 详细信息

关键词： Potassium Periodate determination of metal ions

四极杆质谱、串联质谱系统在测定血液中毒鼠强的应用

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分析测试学报 2001年第Z1期20卷 294-295页

作者：武继锋李荀济南市公安局刑警支队山东济南250002 山东大学化学院山东济南250100

毒鼠强又名424,化学名称为四次甲基二砜四胺(C4H8O4N2S2),分子量240.6,是一种无色无味白色粉末状物质,难溶于乙醇,微溶于水,易溶于丙酮、苯、乙醚,性质稳定,投毒后,不易被人们察觉,一旦中毒,发作快,死亡率高.多数医院难确诊、治疗.目前... 详细信息

毒鼠强又名424,化学名称为四次甲基二砜四胺(C4H8O4N2S2),分子量240.6,是一种无色无味白色粉末状物质,难溶于乙醇,微溶于水,易溶于丙酮、苯、乙醚,性质稳定,投毒后,不易被人们察觉,一旦中毒,发作快,死亡率高.多数医院难确诊、治疗.目前,对其主要的鉴定法有GC、GC-MS和HPLC等.通常在对毒鼠强中毒的生物检材进行毒鼠强分析时,由于生物组织机体中存在的干扰物质(如脂肪酸、胆固醇等)种类繁多,经净化处理后,其残留量仍然很大,不仅干扰目标化合物的定性,更难进行定量测定.因此GC-MS在定性分析中具有明显优势,因而成为目前主要的分析方法.……

关键词：四极杆质谱串联质谱系统定量测定血液毒鼠强中毒应用 determination of 四次甲基二砜四胺干扰物质生物组织生物检材净化处理化学名称干扰目标分析方法定性分析脂肪酸死亡率鉴定法

LC-MS/MS法研究大鼠脑透析液中氨丁苯酞的动态变化及其代谢产物

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质谱学报 2003年第Z1期24卷 65-66页

作者：乔晋萍侯佩玲褚凤鸣再帕尔·阿不力孜赵丽艳夏敏常雁郭宗儒中国医学科学院中国协和医科大学药物研究所北京100050 北京理化测试中心北京100089

　　微透析是以透析原理作为基础的在体取样技术,是在非平衡条件下灌注埋在组织中的微透析探针,组织中待测化合物沿浓度梯度逆向扩散进入透析液,被连续不断地带出,从而达到从活体组织中取样的目的.这是一种动态连续的取样方法,在药物代... 详细信息

　　微透析是以透析原理作为基础的在体取样技术,是在非平衡条件下灌注埋在组织中的微透析探针,组织中待测化合物沿浓度梯度逆向扩散进入透析液,被连续不断地带出,从而达到从活体组织中取样的目的.这是一种动态连续的取样方法,在药物代谢和药代动力学研究中的应用倍受关注[1].……

关键词：大鼠脑透析液苯酞动态变化代谢产物 Liquid Chromatography determination of 药代动力学研究活体组织微透析探针取样技术药物代谢透析原理取样方法平衡条件浓度梯度化合物应用逆向基础

液相色谱-串联质谱法测定人体血浆中格列本脲浓度

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质谱学报 2003年第Z1期24卷 77-78页

作者：郭继芬张爱军赵毅民乔善义军事医学科学院毒物药物研究所北京100850

　　在2型糖尿病的治疗中,常常需要联用两种或多种降糖药.为了满足临床需要,开发了格列本脲和盐酸二甲双胍复合片,将这两种作用机制互补的降糖药组成复方制剂,以改善2型糖尿病患者的血糖控制[1].为了研究该复方制剂中格列本脲的药代动... 详细信息

　　在2型糖尿病的治疗中,常常需要联用两种或多种降糖药.为了满足临床需要,开发了格列本脲和盐酸二甲双胍复合片,将这两种作用机制互补的降糖药组成复方制剂,以改善2型糖尿病患者的血糖控制[1].为了研究该复方制剂中格列本脲的药代动力学特性,我们建立了格列本脲血药浓度测定的液相色谱-串联质谱法.分析了20名健康志愿者口服复方格列本脲片、与二甲双胍同时给药的格列本脲单方制剂后格列本脲血药浓度.已有文献报道采用HPLC-UV[2,3]和HPLC-MS[4,5]法测定血浆中格列本脲浓度,但在灵敏度或专属性方面则低于本所建立的方法.……

关键词：液相色谱串联质谱法血药浓度测定人体血浆格列本脲浓度 Human Plasma determination of 型糖尿病复方制剂盐酸二甲双胍降糖药糖尿病患者健康志愿者格列本脲片动力学特性作用机制血糖控制单方制剂专属性灵敏度

Changes of dynamical balance of free radicals induced by levodopa in rat glia-containing mesencephalic culture fluid

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Neural Regeneration Research 2006年第5期1卷 401-404页

作者： Wenxia Li Shenggang Sun Jingru Wang Baoliang Sun Yanbo Zhang Deparlment of Neurology Affiliated Hospital of Taishan Medical University Taian 271000Shandong Province China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022 Hubei Province. China

BACKGROUND ： Parkinson disease is neurodegenerative disorders, characterized by a progressive and selective degeneration of nigrostdatal dopaminergic pathway. Its main clinical symptoms include bradykinesia, dgidity, rest tremor and disturbances in balance. Levodopa （L-DOPA） is the ＂gold standard＂ for the symptomatic treatment of Parkinson disease, but L-DOPA is toxic to dopaminergic neurons and the chronic administration of L-DOPA often causes the side effects of motor such as ＂on-off ＂, etc., and its mechanism still has not been completely clarified. OBJECTIVE ： To observe the changes of the content of glutathione （GSH）, activities of glutathione peroxidase （GSH-Px） and superoxide dismutase （SOD） and content of malondialdehyde （MDA） in gila-containing mesencephalic culture fluid after L-DOPA of different concentrations were added. DESIGN： A comparative observation. SETTINGS ： Department of Neurology, Affiliated Hospital of Taishan Medical University; Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. MATERIALS ： The experiment was carried out in the Basic Research Institute, Taishan Medical University from December 2003 to September 2004. Ten postnatal newborn SD rats （within 2 days） were selected, either male or female. Fetal bovine serum （DMEM/F12） was from Gibco Company; L-DOPA and glial fibrillary acidic protein （GFAP） from Sigma Company. Kits for determination of GSH, GSH-Px, SOD and MDA were purchased from Nanjing Jiancheng Bioengineering Research Institute. METHODS ： Gila-containing mesencephalic culture fluid were placed in 24-well culture plate, and L-DOPA of 50, 100 and 500 μmot/L was added to each group, the blank control group was also set. The glia-containing mesencephalic culture fluid selected at 4, 24, 48 and 72 hours respectively to determine the GSH content with colorimetdc quantitative technique, GSH-Px activity with colorimetdc method, SOD activity with xanthine oxidase meth

关键词： free radicals Parkinson disease neurodegenerative disorders Science and Technology glutathione peroxidase superoxide dismutase dopaminergic neurons colorimetric method dynamical balance xanthine oxidase determination of Basic Research acidic protein side effects time point

Development of A New Type of Specific Gravity Sensor Based On Capacitive Principle for Soil Suspension Measurement Applications

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测试技术学报 2002年第Z2期16卷 1549-1558页

作者： Wanjun Wang Zhongjie Zhang Department of Mechanical Engineering Louisiana State University Baton Rouge LA 70803 Louisiana Transportation Research Center 4101 Courrier Avenue Baton Rouge Louisiana 70808-4443

In this paper, we report a research effort to develop a computerized testing device based on capacitive principle that can be used to measure the soil suspension and the grain size distribution. The device may cut the test time discussed above by 75%. It may also automate the test and analysis processes to insure the quality of determination of soil grain-size distribution by eliminate operator reading error.

关键词： Soil Suspension grain size distribution determination of soil suspension testing device