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Spatial and temporal distribution of trace elements in Yangtze Estuary,China: Significance of diluted setting

Chinese Science Bulletin 2001年第S1期46卷 65-73页

作者： WANG Zhanghua CHEN Zhongyuan LI Luqian WEI Taoyuan Department of Geography East China Normal UniversityShanghai 200062China State Key Laboratory for Estuarine and Coastal Research East China Normal UniversityShanghai 200062China

The present study is to examine the spatial and temporal distribution of eight trace elements (Sr, Ba, B, Ga, Ni, V, Cu, and F) in various Holocene marine subfacies in the Yangtze Estuary, including its subaqueous delta by sediment borehole and vibrocore. Results demonstrate that grain size is the determinant factor in controlling the concentration of most trace elements discussed. Prodelta mud that occurs usually below the normal wave base can serve as a depository sink for trapping trace elements over the long-term time period. For example, copper concentration is 5-6 times higher than those found in the estuarine sediment. Boron, which is used to be a salinity indicator, shows a strong negative correlation with paleosalinity (using sediment phosphate method), implying desalinized water setting in the Yangtze Estuary, into which a large quantity of the Yangtze freshwater (924×109 m3/a) has discharged. Trace element concentrations of the study area were compared with those collected from the middle

关键词： boron depository sink Holocene palaeosalinity prodelta mud trace elements transit environment Yangtze Estuary.

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Novel diagnosis and therapy for hepatoma targeting HBV-related carcinogenesis through alternative splicing of FIR (PUF60)/FIRΔexon2

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Hepatoma Research 2018年第9期4卷 142-158页

作者： Kazuyuki Matsushita Tyuji Hoshino Department of Laboratory Medicine&Division of Clinical Genetics and Proteomics Chiba University HospitalChiba260-8677Japan Department of Physical Chemistry Chiba UniversityChiba 260-8670Japan

Aim: Disturbed alternative splicing of far upstream element-binding protein-interacting repressor (FIR) was found to be unable to repress c-Myc transcription and so it might be important for suppressing tumor development. FIR is a splicing variant of poly (U)-binding-splicing factor (PUF60), and forms complex with other splicing factors. FIR/PUF60 is a splicing factor of U2 small nuclear ribonucleoprotein auxiliary factor family, Thus FIR/PUF60 is a multifunctional protein. The expression of exon2-lacking splicing variant of FIR, FIRΔexon2, is elevated in many cancer tissues and promotes tumor development by disabling FIR-repression to sustain c-Myc activation. FIRΔexon2, as a dominant negative of FIR, opposed apoptosis in cancer cells. FIR/FIRΔexon2 interacts with degron pocket of F-box and W (Typ) D (Asp) repeat domain-containing 7 and inhibits proteolysis of substrates proteins. Recently, FIR/PUF60 was identified as a versatile regulator of transcriptional and post-transcriptional steps in expression of hepatitis B virus (HBV) pregenomic RNA (pgRNA) expression. Methods: Small molecular chemical compounds against FIR and FIRΔexon2 were screened among 2,3275 chemicals by natural product depository array (RIKEN, Wako, Saitama, Japan). Results: Nine chemicals against FIR and four chemicals against FIRΔexon2 were identified as candidates of interacting chemicals. Interestingly, BK697 contains WD -like structure. Among them, BK697 against FIRΔexon2 inhibited hepatoma cell growth. Conclusion: Therefore, FIR (PUF60)/FIRΔexon2 is multifunctional and applicable for clinical use for HBV suppression and hepatoma treatment. Together, one clue to the development of hepatome diagnosis and therapies directed against FIR/FIRΔexon2/PUF60 with small molecular weight chemicals that inhibit HBV cccDNA replication.

关键词： Hepatocellular carcinoma hepatitis B virus covalently closed circular DNA far upstream element-binding protein-interacting repressor poly (U)-binding-splicing factor F-box and W (Typ) D (Asp) repeat domain-containing 7 natural product depository array U2A

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