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Science China Chemistry 2016年第12期59卷 1593-1599页

作者： Bin Wang Shiyang Shao Junqiao Ding Lixiang Wang Xiabin Jing Fosong Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

On the basis of different generation carbazole dendrons, a series of self-host yellow Ir dendrimers （Y-G0, Y-G1 and-G2） have been successfully synthesized and characterized in detail. It is found that the peripheral dendrons can effectively reduce the intermolecular interactions between emissive Ir cores, as verified by the increased photoluminescence quantum yields and film lifetimes. Among these dendrimers, Y-G2 bearing the second generation dendrons shows the best non-doped device per- formance, revealing a peak luminous efficiency of 20.2 cd/A. The value is nearly twice that of Y-G0 without any dendrons, which could be further improved to 32.1 cd/A by dispersing Y-G2 into a host matrix. We believe that this work will shed light on the development of highly efficient yellow phosphorescent dendrimers with a self-host strategy.

关键词： iridium dendrimers carbazole self-host solution-processed OLEDs

Multifunctional Cholesterol-modified dendrimers for Targeted Drug Delivery to Cancer Cells Expressing Folate Receptors

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Chinese Journal of Polymer Science 2019年第2期37卷 129-135页

作者： Fan-Fan Fu Ben-Qing Zhou Zhi-Jun Ouyang Yi-Lun Wu Jing-Yi Zhu Ming-Wu Shen Jin-Dong Xia Xiang-Yang Shi Key Laboratory of Science & Technology of Eco-Textile Ministry of Education College of Chemistry Chemical Engineering and Biotechnology Donghua University Department of Radiology Shanghai Songjiang District Central Hospital

We present here the development of cholesterol(Chol)-modified dendrimer system for targeted chemotherapy of folate(FA)receptor-expressing cancer cells. In our study, poly(amidoamine)(PAMAM) dendrimers of generation 5(G5) were functionalized stepby-step with Chol, fluorescein isothiocyanate(FI), and FA via a poly(ethylene glycol)(PEG) spacer(PEG-FA), and then acetamide to shield their remaining surface amines. The synthesized ***-Chol-FI-PEG-FA(for short, G5-CFPF) dendrimers were utilized to encapsulate 10-hydroxycamptothecin(HCP), a hydrophobic anticancer drug. We find that each G5-CFPF dendrimer can encapsulate 13.8 HCP molecules. The complexes show a slower release profiles of HCP in a pH-dependent manner than the control complexes formed using the same dendrimers without Chol under the same conditions. Thanks to the targeting role played by FA, the complexes display a specific inhibition efficacy to FA receptor-expressing cervical cancer cells. The designed Chol-modified dendrimers may be adopted as a promising carrier for application in targeted cancer therapy.

关键词： PAMAM dendrimers Folate Cholesterol 10-Hydroxycamptothecin Targeted cancer therapy

Multiplexing technology for in vitro diagnosis of pathogens： the key contribution of phosphorus dendrimers

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Science China Materials 2018年第11期61卷 1454-1461页

作者： Jean Pierre Majoral Jean Marie Francois Richard Fabre Alice Senescau Serge Mignani Anne-Marie Caminade Laboratoire de Chimie de Coordination du CNRS 31077 Toulouse Cedex 4France LCC-CNRS Universit6 de Toulouse CNRSToulouseFrance Dendris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Universite Paris Descartes PRES Sorbonne Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on Pasteur's method and polymerase chain reaction(PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

关键词： phosphorus dendrimers diagnosis DNA arrays multiplexing technology

New-generation biomedical materials:Peptide dendrimers and their application in biomedicine

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Science China Chemistry 2010年第3期53卷 458-478页

作者： GU ZhongWei,LUO Kui,SHE WenChuan,WU Yao & HE Bin National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China 1. National Engineering Research Center for Biomaterials Sichuan University Chengdu 610064 China

Peptide dendrimers are attractive synthetic polymers and have been widely used as a new generation of biomaterials in recent *** dendrimers,as well as general dendrimers,may be synthesized to reach nano sizes,and display well-defined architectures,highly-branched structures,high density of functional terminal groups,and controllable molecular *** the other hand,peptide dendrimers have properties similar to proteins and some special characteristics,such as good biocompatibility,water solubility and resistance to proteolytic *** to these advantages,peptide dendrimers have received considerable attention in *** review focuses on the development of peptide dendrimers with emphasis on their applications both in diagnostics and in therapy.

关键词： peptide dendrimers molecular probes drug delivery gene delivery

A General Procedure for Surface Modification of Nano-alumina and Its Application to dendrimers

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Journal of Wuhan University of Technology(Materials Science) 2007年第3期22卷 453-456页

作者：王斌郭朝霞 Institute of Polymer Science and Engineering Department of Chemical EngineeringSchool of Materials Science and EngineeringTsinghua University

A general procedure for surface modification of nano-alumina using N, N＇-dicyclohexyl- carbodiimide （DCC） mediated amidation is reported. Aliphatic and aromatic carboxylic acids reacted smoothly with nano-alumina pretreated with 3-aminopropyltriethoxysilane in the presence of DCC, giving modified aluminas having organic surfaces. The grafted aluminas have been characterized qualitatively by FT-IR or ^13C CPMAS NMR spectroscopy, and quantitatively by thermogravimetric analysis and elemental analysis. The procedure was applied to polyether dendrons bearing carboxyl groups at the focal points, giving successful grafting of dendrimers onto nano-alumina.

关键词： nano-alumina N, N'-dicyclohexyl-carbodiimide (DCC) surface modification dendrimers

Convergent synthesis of second generation CCK-functional dendrimers

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Chinese Chemical Letters 2009年第1期20卷 9-12页

作者： He Gu Guo Li Cheng Lin Zhang Yu Jiang Bo Key Laboratory of Drug Targeting of Ministry of Education and Department of Medicinal Chemistry West China School of Pharmacy Sichuan University Chengdu 610041 China

This paper describes the facile synthesis and characterization of novel dendrimers bearing 9 and 12 CCK peptide fragments on the surface by a convergent method. The structures of dendrimers are characterized by NMR an... 详细信息

关键词： dendrimers CCK Synthesis

应用PAMAM dendrimers作为DNA运送载体的体外研究

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生物化学与生物物理进展 2004年第9期31卷 804-811页

作者：郭晨莹王恒蔺亚晖蔡启良中国医学科学院基础医学研究所中国协和医科大学基础医学院病原生物学系分子寄生虫学实验室北京100005

StarburstTMPAMAMdendrimers分子是一类新型的高分枝、辐射状对称的树状高分子,在生理条件下其表面具有高密度的正电荷,可以通过静电相互作用与核酸形成复合物后,介导遗传物质进入细胞.研究了G3,G3 5,G5,G7,G7 5,G9各代dendrimers分子与... 详细信息

StarburstTMPAMAMdendrimers分子是一类新型的高分枝、辐射状对称的树状高分子,在生理条件下其表面具有高密度的正电荷,可以通过静电相互作用与核酸形成复合物后,介导遗传物质进入细胞.研究了G3,G3 5,G5,G7,G7 5,G9各代dendrimers分子与DNA结合后介导其转染细胞的能力,并初步评价这种复合物转染对细胞活力的影响.实验证实,全代的PAMAMdendrmers皆可与DNA结合,并可在体外培养的细胞中介导高效的DNA转染.PAMAMdendrimer/DNA复合物很稳定,在较大的pH值变化范围内(pH 2～ 10 )不解离.PAMAMdendrimers可保护与之复合的DNA分子免受限制性内切酶的降解.在一定的电荷比范围内,高代数的dendrimers分子与DNA形成的复合物对培养细胞的转染效率高于低代数dendrimer分子,复合物所介导的转染效率在不同的细胞系之间也有差异.在有效作用浓度范围内(≤ 1 3× 10 -1g/L),PAMAMdendrimers/DNA复合物对被转染细胞无毒性.但是,未与DNA复合的dendrimers分子在较低浓度时则表现出毒性,表明StarburstTM PAMAMdendrimers分子可作为新型的低毒非病毒DNA载体,用于介导DNA对体外培养细胞的转染.这些前期观察。

关键词： DNA转运 Starburst^TM PAMAM dendrimers 转染非病毒载体

Recent therapeutic applications of the theranostic principle with dendrimers in oncology

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Science China Materials 2018年第11期61卷 1367-1386页

作者： Serge Mignani Joao Rodrigues Helena Tomas Anne-Marie Caminade Regis Laurent Xiangyang Shi Jean-Pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging

Starburst^(TM) Polyamidoamine dendrimers介导的绿色荧光蛋白基因在小鼠体内的表达分布及对恶性疟DNA疫苗ES312免疫原性的影响

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中国医学科学院学报 2005年第4期27卷 499-503,i0003页

作者：丁俊军郭晨莹蔡启良蔺亚晖王恒中国医学科学院中国协和医科大学基础医学研究所分子寄生虫实验室北京100005 Department of Neurobiology David Geffen School of Medicine at UCLALos AngelesCalifornia

目的研究StarburstTMPolyamidoamine(PAMAM)dendrimers介导绿色荧光蛋白基因在小鼠体内的表达分布及对恶性疟DNA疫苗ES312免疫原性的影响。方法经股四头肌给小鼠注射StarburstTMPAMAMdendrimers与绿色荧光蛋白基因或恶性疟DNA疫苗ES312的复合物。通过流式细胞术、Westernblot和间接免疫荧光方法检测绿色荧光蛋白的表达分布和表达量。用ELISA方法检测恶性疟DNA疫苗ES312的免疫原性。结果在注射StarburstTMPAMAMdendrimers/DNA复合物后2h～7d内,StarburstTMPAMAMdendrimers携带的绿色荧光蛋白基因的表达在小鼠的心、肝、脾、肺、肾、脑、肌肉中均能被检测到,在肾总蛋白中所占百分比最高,且各器官管腔内皮细胞中的绿色荧光蛋白表达量较高。小鼠的脑和肾中,在StarburstTMPAMAMdendrimers的存在下,绿色荧光蛋白基因的表达量明显高于裸DNA的表达量。经StarburstTMPAMAMdendrimers携带的恶性疟DNA疫苗ES312诱导的抗体反应水平明显高于单纯裸DNA疫苗所诱导的抗体水平。结论StarburstTMPAMAMdendrimers作为一种低抗原性、非病毒的新型DNA载体,能够明显提高裸DNA在体内的表达水平,诱导产生很强的体液免疫反应。但是,StarburstTMPAMAMdendrimers/DNA复合物在各组织器官中的广泛分布,尤其是透过血脑屏障的能力,已超出疫苗载体的适用范围。作为DNA疫苗载体,要对现有StarburstTMPAMAMdendrimers分子的结构做进一步的修饰。

关键词： DNA转运 Starburst polyamidoamine dendrimers 体内表达免疫原性

纳米材料在基因转染中的应用——Starburst PAMAM dendrimers研究现状

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基础医学与临床 2002年第2期22卷 103-105页

作者：郭晨莹王恒中国医学科学院中国协和医科大学基础医学研究所分子寄生虫学实验室北京100005

提高重组DNA对培养细胞及活体水平的转染效率是利用重组DNA进行预防和治疗疾病所必须解决的难题之一。一种新型阳离子多聚物———StarburstPAMAMdendrimers的出现为解决现存的难题带来了一线曙光。StarburstPAMAMdendrimers是 1985年... 详细信息

提高重组DNA对培养细胞及活体水平的转染效率是利用重组DNA进行预防和治疗疾病所必须解决的难题之一。一种新型阳离子多聚物———StarburstPAMAMdendrimers的出现为解决现存的难题带来了一线曙光。StarburstPAMAMdendrimers是 1985年之后出现的一类新型星射状树形高分子 ,它们结构规整 ,具有呈辐射状对称的刚性球体结构 ,在生理条件下 ,StarburstPAMAMdendrimers分子具高的表面正电荷密度 ,能与天然状态下存在的带负电荷的生物活性物质 (如核酸 )发生静电相互作用形成复合物。该类树形高分子可极大增强DNA转染真核细胞的转染效率 ,具有许多优于其它现有转染试剂的优良特性 ,并具有在活体内应用的潜力。本文介绍了九十年代以来对该类树形高分子在体外培养细胞及活体水平增强DNA转染效率的研究现状并对今后的研究和应用进行了分析。

关键词：纳米材料基因转染 Starburst PAMAM dendrimers 树形高分子