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Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery

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Science China Chemistry 2009年第7期52卷 961-968页

作者： CHENG Jing1 & WANG Jun2 1 Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China 2 Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China Department of Polymer Science and Engineering University of Science and Technology of China Hefei China Hefei National Laboratory for Physical Sciences at Microscale School of Life Sciences University of Science and Technology of China Hefei China

Biodegradable and amphiphilic triblock copolymers poly(ethyl ethylene phosphate)-poly(3-hydroxybutyrate)-poly(ethyl ethylene phosphate) (PEEP-b-PHB-b-PEEP) have been successfully synthesized through ring-opening polymerization. The structures are confirmed by gel permeation chromatography and NMR analyses. Crystallization investigated by X-ray diffraction reveals that the block copolymer with higher content of poly(ethyl ethylene phosphate) (PEEP) is more amorphous, showing decreased crystallizability. The obtained copolymers self-assemble into biodegradable nanoparticles with a coreshell micellar structure in aqueous solution, verified by the probe-based fluorescence measurements and transmission electronic microscopy (TEM) observation. The hydrophobic poly(3-hydroxybutyrate) (PHB) block serves as the core of the micelles and the micelles are stabilized by the hydrophilic PEEP block. The size and size distribution are related to the compositions of the copolymers. Paclitaxel (PTX) has been encapsulated into the micelles as a model drug and a sustained drug release from the micelles is observed. MTT assay also demonstrates that the block copolymers are biocompatible, rendering these copolymers attractive for drug delivery.

关键词： poly(3-hydroxybutyrate) polyphosphoester drug delivery polymeric nanoparticles

Recent advances of microneedles for biomedical applications: drug delivery and beyond

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Acta Pharmaceutica Sinica B 2019年第3期9卷 469-483页

作者： Jian Yang Xinli Liu Yunzhi Fu Yujun Song College of Materials Science and Chemical Engineering Hainan UniversityHaikou570228China College of Engineering and Applied Sciences Nanjing UniversityNanjing210093China

The microneedle(MN), a highly efficient and versatile device, has attracted extensive scientific and industrial interests in the past decades due to prominent properties including painless penetration, low cost, excellent therapeutic efficacy, and relative safety. The robust microneedle enabling transdermal delivery has a paramount potential to create advanced functional devices with superior nature for biomedical applications. In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing(3DP). Importantly, a variety of representative biomedical applications of microneedles such as disease treatment, immunobiological administration, disease diagnosis and cosmetic field, are highlighted in detail. At last, conclusions and future perspectives for development of advanced microneedles in biomedical fields have been discussed systematically. Taken together, as an emerging tool, microneedles have showed profound promise for biomedical applications.

关键词： Microneedle patches Biomedical applications Microfabricated device Drug delivery Disease treatment Disease diagnosis Immunobiological administration 3D printing

Enhanced recovery after cesarean delivery:a challenge for anesthesiologists

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Chinese Medical Journal 2020年第5期133卷 590-596页

作者： Zhi-Qiang Liu Wei-Jia Du Shang-Long Yao Department of Anesthesiology Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China Tongji University School of Medicine Shanghai 200092China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Enhanced recovery after cesarean(ERAC)delivery is an evidence-based,multi-disciplinary approach throughout pre-,intra-,postoperative *** ultimate goal of ERAC is to enhance recovery and improve the maternal and neonatal *** review highlights the role of anesthesiologist in ERAC *** review provided a general introduction of ERAC including the purposes and the essential elements of ERAC *** tool used for evaluating the quality of ERAC(ObsQoR-11)was *** role of anesthesiologist in ERAC should cover the areas including management of peri-operative hypotension,prevention and treatment of intra-and post-operative nausea and vomiting,prevention of hypothermia and multi-modal perioperative pain management,and active pre-operative management of unplanned conversion of labor analgesia to cesarean delivery *** some concerns still remain,ERAC implementation should not be *** assessment and process improvement should be imbedded into the *** high-quality studies are warranted to demonstrate the effectiveness and efficacy of the ERAC protocol.

关键词： Cesarean delivery Cesarean section Enhanced recovery after surgery

Plasmonic nanoparticles and nucleic acids hybrids for targeted gene delivery,bioimaging,and molecular recognition

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Journal of Innovative Optical Health Sciences 2021年第4期4卷 3-30页

作者： Timofey Pylaev Elena Avdeeva Nikolai Khlebtsov Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences Saratov 410049Russia Razumovsky Saratov State Medical University Saratov 410012Russia Federal Center of Agriculture Research of the South-East Region Saratov 410010Russia Saratov National Research State University Saratov 410012Russia

Promising biomedical applications of hybrid materials composed of gold nanoparticles and nucleic acids have attracted strong interest from the nanobiotechnological *** particular interest is owing to the robust and easy-to-make synthetic approaches,to the versatile optical and catalytic properties of gold nanoparticles combined with the molecular recognition and programmable properties of nucleic *** significant progress is made in the develop-ment of DNA-gold nanostructures and their applications,such as molecular recognition,cell and tissue bioimaging,targeted delivery of therapeutic agents,*** review is focused on the critical discussion of the recent applications of the gold nanoparticles-nucleic acids *** effect of particle size,surface,charge and thermal properties on the interactions with functional nucleic acids is *** each of the above topics,the basic principles,recent advances,and current challenges are *** is placed on the systematization of data over the theranostic systems on the basis of the gold nanoparticles-nucleic acids ***,we start our discussion with observation of the recent data on interaction of various gold nano-particles with nucleic *** we describe existing gene delivery systems,nucleic acids detection,and bioimaging ***,we describe the phenomenon of the polymerase chain reaction improvement by gold nanoparticle additives and its potential underlying ***,we provide a short summary of reported data and outline the challenges and perspectives.

关键词： gold nanoparticles delivery DNA detection bioimaging

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes:current perspectives and future challenges

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Acta Pharmaceutica Sinica B 2016年第4期6卷 287-296页

作者： Dinh Ha Ningning Yang Venkatareddy Nadithe Manchester University College of Pharmacy Natural & Health Sciences

Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body's own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.

关键词： Exosomes Nanocarrier Extracellular vesicles Drug delivery systems

Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application

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Acta Pharmaceutica Sinica B 2019年第4期9卷 675-689页

作者： Qing Xia Yongtai Zhang Zhe Li Xuefeng Hou Nianping Feng Department of Pharmaceutical Sciences Shanghai University of Traditional Chinese Medicine

Erythrocytes(red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems(DDS) because of their features of biocompatibility,biodegradability, and long circulating half-life. Accordingly, a 'camouflage' comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed,providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems.

关键词： Red blood cells Membrane Nanoparticles Drug delivery Antitumor Biomimetic nanoparticles

Spatial Pattern and Influencing Factor Analysis of Attended Collection and delivery Points in Changsha City, China

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Chinese Geographical Science 2019年第6期29卷 1078-1094页

作者： XUE Shuyan LI Gang YANG Lan LIU Ling NIE Qifan Muhammad Sajid MEHMOOD College of Urban and Environmental Sciences Northwest UniversityXi’an 710127China Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi’an 710127China Department of Civil Construction and Environmental EngineeringUniversity of Alabama SystemTuscaloosa 35401USA

Attended collection and delivery points are vital components of ‘last-mile logistics’.Based on point of interest(POI) data for Cainiao Stations and China Post stations in Changsha City, China, this paper provides a detailed exploration of the basic features, spatial distribution, and location influencing factors of attended collection and delivery ***, analyses of the types, service objects and location distributions of the attended collection and delivery points alongside a discussion of their spatial pattern and influencing factors provides a reference for their general geographic layout and *** findings of this study indicate that: 1) The main mode of operation of attended collection and delivery points is franchises, with other modes of operation rely on supermarkets and other individual shop types.2) The main service targets of attended collection and delivery points are communities, schools, and businesses, followed by townships, enterprises, scenic spots, and administrative units.3) Approximately 77.44% of the attended collection and delivery points are located near the exits of service areas;others are situated in the centre of the service *** the Cainiao Stations, 80% are located within 125 m of the exit;for the China Post stations, 80% are located within 175 m of the exit.4) The spatial distribution of the attended collection and delivery points in Changsha is unbalanced, with ‘more centre and fewer surrounding’.The centre is an ‘inverted triangle’, and the edge is an ‘orphan’, showing a northwest-southeast orientation and symmetrical along the *** layout of the attended collection and delivery points forms three core areas, and the number of sites decreases with the distance from the core.5) The number and distribution of the attended collection and delivery points are strongly consistent with the regional economic development level, population, and roadway system traffic *** attended collection and

关键词： attended collection and delivery points Cainiao Stations China Post stations spatial pattern influencing factors Changsha, China

Adapting liposomes for oral drug delivery

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Acta Pharmaceutica Sinica B 2019年第1期9卷 36-48页

作者： Haisheng He Yi Lu Jianping Qi Quangang Zhu Zhongjian Chen Wei Wu Key Laboratory of Smart Drug delivery of MOE and PLA School of Pharmacy Fudan University Shanghai Dermatology Hospital

Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes,oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract,difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.

关键词： Liposomes Oral Drug delivery Stability Absorption Bioavailability

Charge-reversal nanoparticles: novel targeted drug delivery carriers

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Acta Pharmaceutica Sinica B 2016年第4期6卷 261-267页

作者： Xinli Chen Lisha Liu Chen Jiang Key Laboratory of Smart Drug delivery Ministry of Education Department of PharmaceuticsSchool of Pharmacy Fudan University State Key Laboratory of Medical Neurobiology Fudan University

Spurred by significant progress in materials chemistry and drug delivery, charge-reversal nanocarriers are being developed to deliver anticancer formulations in spatial-, temporal- and dosagecontrolled approaches. Charge-reversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface. They can elude clearance from the circulation and be activated by protonation, enzymatic cleavage, or a molecular conformational change. In this review, we discuss the physiological basis for, and recent advances in the design of charge-reversal nanoparticles that are able to control drug biodistribution in response to specific stimuli, endogenous factors(changes in p H,redox gradients, or enzyme concentration) or exogenous factors(light or thermos-stimulation).

关键词： Cancer therapy Charge-reversal nanoparticles Drug delivery carriers Stimuli responsive Nanotechnology