检索结果-南通市图书馆

dehydroabietic acid chemosensitizes drug-resistant acute lymphoblastic leukemia cells by downregulating survivin expression

引用

Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 383-390页

作者： Li-Li Shen Wei-Hua Huang Hui-Jun Zhao Xue-Wei Yuan Department of Pediatrics Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhouJiangsuChina

Objective:To explore the mechanism of drug resistance in acute lymphoblastic leukemia and the anti-tumor effect of combination therapy of dehydroabietic acid and vincristine against acute lymphoblastic leukemia ***:Acute lymphoblastic leukemia cells REH and CCRFCEM were employed to detect the anti-tumor effect of vincristine and doxorubicin on proliferation and apoptosis using EdU assay,human active caspase-3 Quantikine ELISA kit,and flow ***-resistant REH cells(REH-R),survivin knockdown and overexpressing REH cells were established to verify the role of survivin in drug ***,in vitro and in vivo assays were performed to determine the effect of dehydroabietic acid on the cytotoxicity of ***:Vincristine and doxorubicin markedly suppressed proliferation and induced apoptosis of REH and CCRF-CEM *** expression was upregulated in REH-R cells compared with REH *** of survivin expression obviously restored the sensitivity of REH-R cells to *** phosphorylation was also increased in REH-R cells compared to REH *** addition,LY294002,a PI3k/Akt pathway blocker,inhibited survivin expression and enhanced cytotoxicity of vincristine to REH-R *** acid effectively reduced survivin expression in REH-R cells,thereby enhancing the therapeutic effect of vincristine on drug-resistant *** overexpression markedly reduced the effect of dehydroabietic acid on enhancing the anti-proliferation and inducing apoptosis effect of ***,the combination of dehydroabietic acid with vincristine significantly extended the survival rate in a mouse xenograft model of acute lymphoblastic leukemia,compared with vincristine treatment ***:dehydroabietic acid may be used as a potential candidate for the treatment of acute lymphoblastic leukemia in combination with vincristine.

关键词： Acute lymphoblastic leukemia Drug resistance Survivin dehydroabietic acid REH cells Vincristine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of dehydroabietic acid

引用

Chinese Journal of Structural Chemistry 2020年第8期39卷 1539-1545,1362页

作者： CAI Xu-Min LI A-Liang LIN Yu-Ting WANG Wen-Yan WANG Shi-Fa GU Wen Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass Jiangsu Key Lab of Biomass-based Green Fuels and ChemicalsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

The title compounds(7a^7g)were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS,1H-and *** crystal structure of compound 7g determined by single-crystal X-ray diffractio is of monoclinic system,space group P21 with a=12.282(3),b=9.940(2),c=22.656(5)A,β=103.06(3)°,Z=2,V=2694.4(10)A^3,Mr=1182.95,Dc=1.458 Mg/m^3,S=1.000,μ=1.649 mm^-1,F(000)=1216,the final R=0.0791 and wR=0.1853 for 4098 observed reflections(Ⅰ>2σ(Ⅰ)).The preliminary antibacterial assay showed that compound 7g exhibits significant inhibitory against Bacillus subtilis,Staphylococcus aureus and Methicillin-resistant ***(MRSA)with MIC values of 1.9~7.8μg/mL.

关键词： dehydroabietic acid benzimidazole sulfonamide crystal structure antibacterial activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Syntheses, Crystal Structures, and Electrochemical Properties of dehydroabietic acid-based Schiff Bases

引用

Chinese Journal of Structural Chemistry 2020年第9期39卷 1699-1706,1557页

作者： CAI Xu-Min CHEN Xin-Fei MU Tian-Qi LIN Yu-Ting HUANG Shen-Lin YAO Min-Xia College of Chemical Engineering Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest BiomassJiangsu Key Lab of Biomass-based Green Fuels and ChemicalsNanjing Forestry UniversityNanjing 210037China School of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816China

Two Schiff bases(DAMBA-Fc and DAA-Fc)derived from dehydroabietic acid have been successfully synthesized and characterized by means of FT-IR,elemental analysis,HRMS,and NMR *** crystal structure of DAA-Fc can be determined by single-crystal X-ray *** compound is of monoclinic system,space group P21 with a=10.7379(6),b=7.5004(4),c=33.3294(18)?,β=97.996(3)o,Z=4,V=2658.2(3)?3,Mr=481.48,Dc=1.203 g/cm3,S=1.034,μ=0.585 mm-1,F(000)=1032,the final R=0.0566 and wR=0.0701 for 5645 observed reflections(I>2σ(I)).In addition,cyclic and differential pulse voltammogram techniques have been applied to differentiate the redox properties of the aromatic-and aliphatic-connected Schiff bases DAMBA-Fc and DAA-Fc,respectively.

关键词： dehydroabietic acid ferrocene Schiff base crystal structure electrochemical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis,Crystal Structure and Cytotoxic Activity of a New N-Vinyl-1H-dibenzo[a,c]carbazole Derivative of the dehydroabietic acid

引用

Chinese Journal of Structural Chemistry 2013年第12期32卷 1904-1910页

作者： GU Wen HAO Yun CHEN Hong-Tu WANG Shi-Fa Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals College of Chemical EngineeringNanjing Forestry University

The title compound （C29H33NO2, 3） was synthesized and structurally characterized by elemental analysis, IR, MS, 1H- and 13C-NMR and single-crystal X-ray diffraction. The crystal is of monoclinic system, space group P21 with a = 14.428（3）, b = 7.3440（15）, c = 22.768（5） A, β = 95.17（3）°, V = 2402.7（8） A3, Z = 4, Mr = 427.56, Dc = 1.182 g/cm3, F （000） = 920, 2（MoKa） = 0.71073 A,μ = 0.073 mm-1, the final R= 0.0670 and wR= 0.1002 for 2437 reflections with I〉 2σ（I） Two crystallographically independent molecules with different conformations co-exist in the structure. The crystal structure is stabilized by intermolecular C-H…π interactions which make the molecules stack along the b axis. In addition, the preliminary cytotoxic assay showed that the title compound exhibited moderate inhibitory activity against KB and SW1116 cells.

关键词： dehydroabietic acid crystal structure 1H-dibenzo[a,c]carbazole cytotoxic activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis,Crystal Structure and Antitumor Activity of a New 3H-Phenanthro-[2,1-d]imidazole Derivative of dehydroabietic acid

引用

Chinese Journal of Structural Chemistry 2015年第9期34卷 1440-1445页

作者：谷文苗婷婷王石发郝云张康平金晓燕 Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals College of Chemical EngineeringNanjing Forestry University

The title compound （CI9H24BrN302, 3） was synthesized from dehydroabietic acid and its crystal structure was determined by single-crystal X-ray diffraction. The compound is of monoclinic system, slSace group C2 with a = 24.830（5）, b = 7.1410（14）, c = 13.981（3） A, p = 107.68（3）°, Z = 4, V= 2361.9（8） A3, Mr = 482.42, Dc = 1.357 Mg/m3, S = 1.003,μ = 1.772 mm1, F（000） = 1008, the final R = 0.0660 and wR = 0.1402 for 2244 observed reflections （I 〉 2o（/））. The crystal structure is stabilized by four hydrogen bonds （O（W）-H（WA）...O（3）, O（W）-H（WB）...O（1）, N（2）-H（2A）...O（W） and N（3）-H（3A）...N（1）） formed among the title compound, the crystal water and acetone molecules. The preliminary antitumor assay showed the title compound exhibited considerable inhibitory activity against HepG2 and SMMC-7721 cell lines with the ICs0 values of 17.1 and 10.2 μM, respectively.

关键词： dehydroabietic acid 3H-phenanthro[2,1-d]imidazole crystal structure antitumor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Crystal Structure of a Novel Lactone Derived from dehydroabietic acid

引用

Chinese Journal of Structural Chemistry 2010年第9期29卷 1327-1330页

作者：张荣江雷茜潘英明王恒山张勇 Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China) School of Chemistry & Chemical Engineering of Guangxi Normal University College of Chemistry and Chemical Engineering Suzhou University

A novel lactone derived from dehydroabietic acid,C20H21BrO4,has been charac-terized by IR,1H NMR,13C NMR and single-crystal X-ray diffraction *** crystallizes in orthorhombic,space group P212121 with a = 6.4195（15）,b = 11.535（3）,c = 24.654（6） ,V = 1825.5（7） 3,Z = 4,Mr = 405.28,Dc = 1.475 g/cm3,λ = 0.71075 ,μ（MoKα） = 2.27 mm-1,F（000） = 832,the final R = 0.024 and wR = 0.045 for 2152 observed reflections with I 2σ（I）.The molecules of lactone are mainly linked through intermolecular hydrogen bonds.

关键词： novel lactone dehydroabietic acid synthesis crystal structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Syntheses and Crystal Structures of 12-Oxime dehydroabietic acid Derivatives

引用

Chinese Journal of Structural Chemistry 2015年第1期34卷 69-76页

作者：崔永梅刘新兰王鹤云林海霞 Department of Chemistry Innovative Drug Research CenterCollege of SciencesShanghai University

Three novel dehydroabietate oxime derivatives were synthesized from dehydroabietic acid and their crystal structures were determined by X-ray crystallographic techniques. All of these 12-oxime dehydroabietic acid derivatives crystallize in orthorhombic system, space group P212121. In the structures, rings A and B exhibit chair and half-chair configurations, respectively and form trans ring junction with two methyl groups（C（19） and C（20）） in the axis positions. The oxime groups have E conformations. Comparison of conformations reveals subtle differences principally in ring B due to the modification in C（12）. The E-acetaldehyde oxime derivative 2c showed distinct BKα gate-opening activity with an ionic current increase of 164% at 30 μM versus the control current.

关键词： crystal structure conformation dehydroabietic acid oxime BKo~ channel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and bulk polymerization kinetics of monomer dehydroabietic acid-(2-acryloyloxy-ethoxy)-ethyl ester

引用

Frontiers of Agricultural Science and Engineering 2017年第1期4卷 97-105页

作者： Haibo ZHANG Yanping YANG He LIU Jie SONG Shibin SHANG Zhanqian SONG National Engineering Laboratory for Biomass Chemical Utilization Key and Open Laboratory of Forest Chemical Engineering State Forestry Administration Key Laboratory of Biomass Energy and Material Institute of Chemical Industry of Forest ProductsChinese Academy of Forestry Department of Chemistry and Biochemistry University of Michigan-Flint Institute of New Technology of Forestry Chinese Academy of Forestry

A bulk polymerization monomer dehydroabietic acid-(2-acryloyloxy-ethoxy)-ethyl ester(DHADG-AC) was synthesized from dehydroabietic acid(DHA). The chemical structure of DHA-DG-AC was characterized by1~HNMR,(13)~CNMR, MS and FT-IR. The kinetics of the bulk polymerization of DHA-DG-AC was investigated by Differential Scanning Calorimeter(DSC).Two kinds of kinetic model(nth-order model and autocatalytic model) were used to investigate the polymerization process. The results showed that the experim e nt al DSC c u r ve s w e r e c o n si st e nt wi th t he computational data generated by the autocatalytic kinetic model, and the value of E_a was 95.73 k J·mol^(–1).

关键词： dehydroabietic acid bulk polymerization kinetics autocatalytic kinetic model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Antifungal Activity of dehydroabietic acid-Based Thiadiazole-Thiazolidinones

Synthesis and Antifungal Activity of Dehydroabietic Acid-Bas...

引用

中国化学会全国第十二届有机合成化学学术研讨会

作者： Chen,Nai-Yuan Duan,Wen-Gui Ma,Yuan Yin,Xian-Long Chen,Zhi-Cong School of Chemistry and Chemical Engineering Guangxi University

dehydroabietic acid is a constituent of pine oleoresin and can be readily obtained from disproportionated *** has been reported to possess antimicrobial,antifungal,insecticidal,gastroprotective and antitumor *** to its broad bioactivities and unique characteristics,dehydroabietic acid has been used to synthesize novel bioactive compounds for many *** our previous works,various dehydroabietic acid-based compounds were synthesized and some of them were found to exhibit good biological activities.[1-6] In continuation of our study on the development and utilization of natural products-based bioactive compounds,a series of novel dehydroabietic acid-based thiadiazole-thiazolidinone compounds were designed and synthesized by integrating 1,3,4-thiadiazole and thiazolidinone heterocyclic moieties into the skeleton of dehydroabietic *** preliminary bioassay showed that the target compounds 3c（R= p-F）,3f（R= o-Br）,and 3n（R= m-OCH3） exhibited excellent inhibition rates of 91.3%（A-class activity level） against Gibberella zeae,which were equivalent to that of the commercial antifungal drug azoxystrobin served as the positive control in this study.

关键词： dehydroabietic acid thiadiazole thiazolidinone synthesis antifungal activity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Synthesis and BK channel-opening activity of novel oxime and oxime ether derivatives from dehydroabietic acid

Synthesis and BK channel-opening activity of novel oxime and...

引用

中国化学会全国第十一届有机合成化学学术研讨会

作者： Xin-Lan Liu He-Yun Wang Hai-Xia Lin Yong-Mei Cui Department of Chemistry Shanghai University

Large-conductance calcium-activated potassium channels(BK channels),widely expressed in various cells and issues of mammals except myocardial cells,responding to two distinct physiological stimuli,i.e.,changes in membrane voltage and in cytosolic Caconcentration,and may serve as a negative feedback pathway to control ionic homeostasis and cell *** that open these channels could have profound impacts on diseases such as acute stroke,epilepsy,asthma,and bladder *** research showed dehydroabietic acid(DHAA,1)derivatives had the potential biological activities in opening BK ***-activity relationship(SAR)studies have also revealed that the 4-carboxyl group was necessary for the activity as the BK channel opener and the substituents of C-12were possibly essential for the ***,we devoted a great deal of efforts to screen 12-substitued oxime and oxime ether derivatives from dehydroabietic acid,aiming at obtaining new bioactive compounds with stronger *** analogues may not only help to elucidate the mechanism of action of BK channels in physiological and pathological conditions,but also lay the foundation for the drug researches on the treatment of cardiovascular and cerebrovascular diseases.

关键词： dehydroabietic acid BK channels openers Oxime

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：