检索结果-南通市图书馆

ibutilide decreases defibrillation threshold by the reduction of activation pattern complexity during ventricular fibrillation in canine hearts

引用

Chinese Medical Journal 2012年第15期125卷 2701-2707页

作者： JIN Qi ZHOU Jian ZHANG Ning LIN Chang-jian PANG Yang GU Gang SHEN Wei-feng WU Li-qun Department of Cardiology Ruijin Hospital Shanghai Jiao TongUniversity School of Medicine Shanghai 200025 China

Background ibutilide has been commonly used for pharmacologic cardioversion of atrial fibrillation and flutter in clinical settings. The objective of this study was to investigate the effects of ibutilide on the defibrillation threshold （DFT）, restitution properties, dispersion of refractoriness and activation patterns during ventricular fibrillation （VF）. Methods ibutilide was administrated intravenously in six open-chest beagles. Before and after the drug administration, 20-second episodes of VF were electrically induced and recorded with a 10×10 unipolar electrode plaque sutured on the lateral epicardium of the left ventricle. DFT and VF activation patterns, including type of epicardial activation maps, VF cycle length （VF-CL）, conduction velocity, wavelength （WL） and reentry incidence, were measured. restitution properties and dispersion of refractoriness were estimated from activation recovery intervals （ARI） during pacing. Results Compared to baseline, ibutilide markedly decreased the DFT by 31% （（491±14） V vs. （337±59） V, P 〈0.01）. The drug significantly reduced the maximal slope of the restitution curve （1.34±0.08 vs. 0.76±0.06, P 〈0.01） and its epicardial dispersion （0.36±0.09 vs. 0.21±0.06, coefficient of variation, P=0.03）. The dispersion of refractoriness was enhanced at the pacing cycle length of 300 ms to 160 ms by ibutilide. The drug significantly increased the VF-CL （（96±19） ms vs. （112±20） ms, P 〈0.01） and the WL （（41±9） mm vs. （52±14） mm, P=0.02） during VF, and reduced the reentry incidence by 25% （0.08±0.02 vs. 0.06±0.02, P 〈0.01）. In the epicardial activation maps, ibutilide significantly reduced the percentage of more complex activation maps during VF. Conclusions Intravenous ibutilide significantly decreased the DFT. It might be due to reduction of activation pattern complexity during VF.

关键词： ventricular fibrillation defibrillation threshold restitution, ibutilide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：