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Science Bulletin 2024年第2期69卷 159-162页

作者： Si-Yuan Yu Yi-Li Liu Zheng Li Dechen Jiang Jing-Juan Xu Hong-Yuan Chen Wei-Wei Zhao State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Nanoelectrodes have been shown to be powerful tools for nanoscopic research on single entities,deepening the understanding of heterogeneity and stochastics for single molecules,nanoparticles and cells[1–3].However,despite their importance,current nanoelectrode preparations are highly restrained to flame/electrochemical etching,metal sputtering,electrochemical deposition,etc.[3],resulting in a limited range of materials(mainly gold,platinum and carbon)for potential-resolved detection of redox-active species(Table S1 online).The enrichment of preparation methods to introduce novel materials and mechanisms should prove significant for the development of nanoelectrodes.

关键词： electrode deepening restrained

Connecting Through Cyberspace Xiamen forum puts spotlight on deepening China-Africa media cooperation through Internet

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ChinAfrica 2024年第5期16卷 30-31页

作者： DONATIEN NIYONZIMA 不详

In an era of connectivity and digital innovation,the China-Africa relationship stands out as a stimulus for international cooperation in the field of the Internet and media cooperation.

关键词： Internet media deepening

New Trends in Oil and Gas Security and Energy Transition

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China Oil & Gas 2024年第3期31卷 3-12页

作者： Sun Longde Zhang Pengcheng Jiang Hang Wang Zugang China National Petroleum Corporation CNPC Economics&Technology Research Institute Research Institute of Petroleum Exploration&Development

The report on the 20th National Congress of the Communist Party of China proposes promoting green development,advancing harmonious coexistence between humans and nature,and ensuring energy security.At COP282023,existing climate targets were reinforced,and a fresh accord was reached for scientifically achieving net-zero carbon emission.The global energy market is being transformed,with oil and gas regaining prominence in energy security.Firms are concentrating on core competencies amidst transitions,though upstream investments show a gradual rebound.The global carbon dioxide capture and storage(CCS)projects has witnessed a significant rise,with Direct Air Capture(DAC)technology gaining attention.Carbon dioxide Capture,Utilization,and Storage(CCUS)is essential as a foundational technology for achieving dual carbon goals.In light of global future development goals and China’s national conditions,this article discusses the evolving trends in the international oil and gas sector alongside China’s domestic energy security landscape.It proposes prospective trajectories for the growth of China’s oil and gas sector and measures to guide and respond to challenges during the energy transition process,providing references for decision-making in the transformation of oil and gas companies.China has a high level of energy self-sufficiency,with the overall energy security situation remaining controllable.China’s oil and gas sector is seeing three-pronged progress:deepening exploration to 10,000s of meters,nano-level reservoir description,and reviving mature fields for a new era.Focusing on deep layer,deepwater,unconventional and mature oilfields,strengthening Belt and Road energy partnerships,enlarging reserves,optimizing pipeline network layout,implementing a smart risk-management ecosystem,and driving the CCUS technology revolution.

关键词： companies Transition deepening

Review of China's Energy Policy in 2023

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China Oil & Gas 2024年第1期31卷 14-21页

作者： Zhang Pengcheng CNPC Economics and Technology Research Institute

In 2023,China's energy policy primarily focused on deepening systemic and institutional reforms,enhancing energy security capabilities,strengthening energy conservation and carbon reduction,and improving the standard system.It has laid the foundation for China's policy direction,which is predicated on ensuring energy security,centered on economic construction,and aimed at achieving the carbon peak and carbon neutrality goals on schedule.In the current key tasks,China has accelerated the construction of a big unified electricity market,vigorously promoted upgrading industries for low-carbon,high-end,and intelligent development,and established carbon markets and standard systems aligned with international practices,achieving substantial progress.

关键词： policy deepening unified

China Marine Xiandai Set to Be aa Leader in Marine Power Generation Equipment Realm

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船舶经济贸易 2024年第4期 74-76页

作者： Wu Xiuxia 不详

Zhenjiang China Marine Xiandai(ZJCMXD)under CSSC Marine Power Co.,Ltd.(CMP)has been adhering to independent research and development for a long time,and constantly deepening the building and promotion of independent brand,increasing the market share of independent brand products year by year.In the past two years,the company's annual generator output(power)and the annual output(number of units/power)of generator sets have repeatedly set a historical record.In 2023,the new orders reached 46 million yuan.

关键词： Marine generator deepening

A MATTER OFTRUST: UNPACKING THE CHINA-U.S.DYNAMIC

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Beijing Review 2024年第1期67卷 18-19页

作者： Rick Dunham Tsinghua University in Beijing

As Xi Jinping,then Vice President of China,prepared for high-stakes meetings in the United States,a top Chinese diplomat lamented the"trust deficit"between the nations and said both sides"must give full attention"to"n... 详细信息

关键词： TRUST deepening mutual

Targeting strategies for bone diseases:signaling pathways and clinical studies

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2714-2748页

作者： Hao Xu Wentao Wang Xin Liu Wei Huang Chen Zhu Yaozeng Xu Huilin Yang Jiaxiang Bai Dechun Geng Department of Orthopedics The First Affiliated Hospital of Soochow University188 Shizi StreetSuzhouJiangsu215006P.R.China Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230031AnhuiChina Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou215006JiangsuChina

Since the proposal of Paul Ehrlich’s magic bullet concept over 100 years ago,tremendous advances have occurred in targeted therapy.From the initial selective antibody,antitoxin to targeted drug delivery that emerged in the past decades,more precise therapeutic efficacy is realized in specific pathological sites of clinical diseases.As a highly pyknotic mineralized tissue with lessened blood flow,bone is characterized by a complex remodeling and homeostatic regulation mechanism,which makes drug therapy for skeletal diseases more challenging than other tissues.Bone-targeted therapy has been considered a promising therapeutic approach for handling such drawbacks.With the deepening understanding of bone biology,improvements in some established bone-targeted drugs and novel therapeutic targets for drugs and deliveries have emerged on the horizon.In this review,we provide a panoramic summary of recent advances in therapeutic strategies based on bone targeting.We highlight targeting strategies based on bone structure and remodeling biology.For bone-targeted therapeutic agents,in addition to improvements of the classic denosumab,romosozumab,and PTH1R ligands,potential regulation of the remodeling process targeting other key membrane expressions,cellular crosstalk,and gene expression,of all bone cells has been exploited.For bone-targeted drug delivery,different delivery strategies targeting bone matrix,bone marrow,and specific bone cells are summarized with a comparison between different targeting ligands.Ultimately,this review will summarize recent advances in the clinical translation of bone-targeted therapies and provide a perspective on the challenges for the application of bone-targeted therapy in the clinic and future trends in this area.

关键词： clinical Ehrlich deepening

Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5572-5574页

作者： Jian Zhou Min Wu Gen Yang Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000 ZhejiangChina School of Physics Peking University100871 BeijingChina

In a recent publication in Nature,1 Mamedov and colleagues identified pathways that modulateγδT cell killing and BTN3A cellular expression through integrating genome-wide CRISPR screens and tumor organoid culture,deepening our comprehension ofγδT cell stress surveillance and proposing novel pathways to boostγδT cell’s anticancer functions(Fig.1).

关键词： integrating deepening culture

Navigating New Market Reforms

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Beijing Review 2024年第26期67卷 25-25页

作者： Lan Xinzhen 不详

The Third Plenary Session of the 20th Central Committee of the Communist Party of China(CPC)will convene in Beijing in July.The session will focus on further deepening reform and promoting Chinese modernization.CPC Central Committee plenums,held at least once a year,are important in outlining the trajectory for China's political,economic and social development.The CPC National Congress and the Central Committee it elects are the highest leading bodies of China's governing Party,with the five-yearly congress setting the national agenda.

关键词： Market deepening congress

When Chinese Dream Meets African Aspiration

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ChinAfrica 2024年第1期16卷 2-2页

The year 2023 witnessed a number of notable events in China-Africa relations that are likely to have far-reaching impact on the future of the relationship.Despite the unrests,conflicts and uncertainties prevailing in many parts of the world,China and African countries saw continuous deepening of political mutual trust and winwin cooperation,moving towards a closer China-Africa community of shared future.

关键词： deepening mutual closer