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Data Mining Study on Prescription Patterns of Different Dosage Forms of Chinese Herbal Medicines for Treating and Improving Immune-Inflammatory Indices in Patients with Rheumatoid Arthritis

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Chinese Journal of Integrative Medicine 2022年第3期28卷 215-222页

作者： HUANG Dan LIU Jian XIN Ling XIE Jin-gui ZHU Qiang CHEN Pei-sheng SHEN Zhi-bin MENG Qing-he WANG Hai-yan Department of Rheumatology First Affiliated Hospital of Anhui University of Chinese MedicineHefei(230031)China The School of Management University of Science and Tech no logy of ChinaHefei(230026)China An hui Jiren Pharmaceutical Co. Ltd.BozhouAnhui Provinee(236800)China Department of Acupuncture Huangshan Hospital of Chinese MedicineHuangshanAnhui Province(245000)China Department of Internal Medicine Bozhou Hospital of Chinese MedicineBozhouAnhui Province(236800)China

Objective:To explore the prescription patterns of different dosage forms of Chinese herbal medicines(CHMs)for the treatment of rheumatoid arthritis(RA)and their effects on immune-inflammatory ***:Clinical data were collected from patients with RA in 4 hospitals(3 Class A comprehensive hospitals and 1 Class B comprehensive hospital)in Anhui Province,China,from August 2012 to June 2018 via the electronic medical record gathering *** extraction of prescription information,each prescribed herb was quantified and standardized according to the knowledge base to establish a database of RA treatment *** medical records were divided into the granules group and decoction pieces *** herbs and their combination patterns were obtained from the two groups of cases using Liquorice *** in immune-inflammatory and hepatic and renal function indices were compared between the two groups using SPSS 23.0 *** Aprior module of SPSS Clementine 11.1 software was applied to analyse the correlation between CHMs and improvement in ***,the ORACLE 10 g tool was used to evaluate the random walk model of the immune-inflammatory indices between the two ***:(1)We retrospectively analysed 35,898 prescriptions for 6,829 patients with RA who received CHM *** were 3,816 patients in the granules group and 3,013 in the decoction pieces group.(2)The core herbs were Pi(Spleen)-strengthening and dampness-resolving drugs,blood-activating and stasis-resolving drugs,wind/dampness-dispelling drugs and heatclearing and detoxifying drugs.(3)Both dosage forms could improve immune-inflammatory indices in RA patients,with similar efficacy and no influence on hepatic or renal function.(4)Herba Siegesbeckiae and Oldenlandia had a stronger association with immune-inflammatory indices in the two groups.(5)The immune-inflammatory indices showed obvious improvement after treatment with granules and decoction pieces of CHMs,and

关键词： rheumatoid arthritis Chinese heral medicine granules decoction pieces data mining

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