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Harnessing decellularised extracellular matrix microgels into modular bioinks for extrusion-based bioprinting with good printability and high post-printing cell viability

引用

Biomaterials Translational 2023年第2期4卷 115-127页

作者： Hanyu Chu Kexin Zhang Zilong Rao Panpan Song Zudong Lin Jing Zhou Liqun Yang Daping Quan Ying Bai Key Laboratory for Polymeric Composite&Functional Materials of Ministry of Education School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Engineering Technology Research Centre for Functional Biomaterials Key Laboratory for Polymeric Composite&Functional Materials of Ministry of EducationSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

The printability of bioink and post-printing cell viability is crucial for extrusion-based bioprinting.A proper bioink not only provides mechanical support for structural fidelity,but also serves as suitable three-dimensional(3D)microenvironment for cell encapsulation and *** this study,a hydrogel-based composite bioink was developed consisting of gelatin methacryloyl(GelMA)as the continuous phase and decellularised extracellular matrix microgels(DMs)as the discrete phase.A flow-focusing microfluidic system was employed for the fabrication of cell-laden DMs in a high-throughput *** gentle mixing of the DMs and GelMA,both rheological characterisations and 3D printing tests showed that the resulting DM-GelMA hydrogel preserved the shear-thinning nature,mechanical properties,and good printability from *** integration of DMs not only provided an extracellular matrix-like microenvironment for cell encapsulation,but also considerable shear-resistance for high post-printing cell *** DM sizes and inner diameters of the 3D printer needles were correlated and optimised for nozzle-based ***,a proof-of-concept bioink composedg of RSC96 Schwann cells encapsulated DMs and human umbilical vein endothelial cell-laden GelMA was successfully bioprinted into 3D constructs,resulting in a modular co-culture system with distinct cells/materials ***,the modular DM-GelMA bioink provides a springboard for future precision biofabrication and will serve in numerous biomedical applications such as tissue engineering and drug screening.

关键词： 3D bioprinting bioinks cell viability decellularised extracellular matrix microgels

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