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decarboxylative acylation of Carboxylic Acids:Reaction Investigation and Mechanistic Study

CCS Chemistry 2022年第7期4卷 2469-2480页

作者： Xiaopeng Wu Jie Han Siyu Xia Weipeng Li Chengjian Zhu Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryShanghai 200032 Advanced Catalytic Engineering Research Center of the Ministry of Education Hunan UniversityChangsha 410082

Ketones serve as one of the most critical building blocks in organic synthesis,involving numerous functional group ***,we rep ort an unprecedented photoredox-nickel metallap hotoredox-catalyzed decarboxylative acylation of common aliphatic acids with readily available aromatic and aliphatic thioesters.A wide range of structurally diverse asymmetrical aryl alkyl and dialkyl ketones have been constructed in yields of up to 98% with this *** protocol has excellent reaction selectivity and functional group compatibility,representing a significant step forward in ketone *** one-pot decarboxylative acylation at the gram scale from two different carboxylic acids and the late-stage application for the synthesis of complex ketones shows its synthetic *** mechanistic experiments and density functional theory(DFT)calculations suggest that the decarboxylative acylation reaction operates via an underdeveloped Ni(Ⅰ)-Ni(Ⅱ)-Ni(Ⅰ)-Ni(Ⅲ)-Ni(Ⅰ)catalytic cycle.

关键词： metallaphotoredox decarboxylative acylation ketones synthesis dual-catalysis carboxylic acid

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Ag-Catalyzed decarboxylative acylation of pyridazines using a-keto acids in aqueous media

Ag-Catalyzed decarboxylative acylation of pyridazines using ...

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河南省化学会2020年学术年会

作者： Shengqiang Wang Xiaobo Xu Qijie Xu The College of Chemistry and Pharmaceutical Engineering Huanghuai University

Pyridazine scaffold is an important class of nitrogen-containing heterocycles which can be frequently found in agrochemistry, functional materials and supramolecular chemistry,meanwhile,the pyridazines motifs are present in an increasing numbers of pharmaceutical products. Acylated pyridazines represent versatile intermediates,the carboxyl can be converted to other different functional *** this paper,an efficient and general protocol for Ag-Catalyzed decarboxylative acylation of pyridazines usingα-keto acids as acylation reagent in aqueous media has been *** method provides a new avenue for the synthesis of diverse array of acylated pyridazines with different substitution *** reaction proceeds smoothly in water under mild conditions and exhibits a good functional group tolerance.

关键词： Pyridazines Ag-Catalyzed α-Keto acids decarboxylative acylation

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