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Environmental hypoxia induces apoptosis in large yellow croaker Larimichthys crocea via both intrinsic and extrinsic pathways

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Journal of Oceanology and Limnology 2023年第6期41卷 2429-2443页

作者： Shengyu LUO Cheng LIU Xinming GAO Jingqian WANG Yibo ZHANG Jie DING Congcong HOU Junquan ZHU Bao LOU Weiliang SHEN Xiongfei WU Chundan ZHANG Key Laboratory of Applied Marine Biotechnology by the Ministry of Education School of Marine SciencesNingbo UniversityNingbo 315211China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory of Large Yellow Croaker Breeding Ningbo Academy of Oceanology and FisheryNingbo 315012China

Hypoxia has become an unfavorable factor affecting the sustainable development of the large yellow croaker Larimichthys crocea,an economically important mariculture fish in *** is a consequence of hypoxia on ***,the effects of hypoxia stress on apoptosis in *** remain largely *** investigated the effect of environmental hypoxia on apoptosis in *** show that hypoxia induced apoptosis in *** both in vivo and in *** mitochondrial membrane potential was significantly reduced in large yellow croaker fry(LYCF)*** expression levels of Bcell lymphoma/leukemia-2(Bcl-2)m RNA and protein were also significantly decreased in the liver and LYCF cells during 96 h and 48 h of hypoxia stress,respectively,whereas the expression level of Bcl-2 associated X(Bax)mRNA,Casp3 mRNA,and activity of caspase-3/7/9 were significantly increased,indicating that hypoxia induced caspase-dependent intrinsic apoptosis in *** expression level of the apoptosis-inducing factor(AIF)protein was significantly increased in the liver and LYCF *** level of AIF protein was significantly decreased in the cytoplasm but increased in the nuclei of ***,demonstrating that hypoxia induced the AIF-mediated caspase-independent intrinsic *** addition,the activity of caspase-8 was significantly increased,indicating that hypoxia stress induced extrinsic apoptosis in ***,hypoxia induced apoptosis in *** through both the intrinsic and extrinsic *** present study accumulated basic biological information to help elucidate the mechanism of hypoxia response in marine fish.

关键词： hypoxia large yellow croaker mitochondrial apoptosis pathway death receptor apoptosis pathway

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apoptosis mechanism of gastric cancer cell SGC-7901 induced by Omphalia lapidescens protein pPeOp

Apoptosis mechanism of gastric cancer cell SGC-7901 induced ...

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2017年浙江省微生物学会青年论坛——微生物与健康专题研讨会

作者：赵肖涯 LU Zhong-xia DU Li-jun LIANG Hao-wei 陈宜涛 College of Life Science Zhejiang Chinese Medicine University

To investigate the apoptosis mechanism of human gastric cancer cell SGC-7901 induced by Omphalia lapidescens protein ***:CCK-8 and flow cytometry were used to detect the inhibitory effect of different concentrations of pPeOp(30,60,90 mg·L) on *** mRNA and protein expression of TNF-R1,Fas/FasL,Bcl-2,caspase-3 and caspase-8 were detected by qRT-PCR and Western ***:SGC-7901 cells were treated with different concentrations of pPeOp(30,60,90 mg·L) for 24 ***-8 test showed that there was no significant difference between PVP group and the control *** survival rate of the 5-Fu group was(53.71±7.34)%(Papoptosis rate of PVP group had no significant difference with control group,and the apoptosis rate of 5-Fu group was about(39.30%±3.34)%(Papoptosis in a dose-dependent *** receptor pathway and mitochondrial pathway may be related to pPeOp-induced apoptosis of gastric cancer SGC-7901.

关键词： apoptosis caspases Gastric cancer SGC-7901 Mitochondrial apoptosis pathway death receptor apoptosis pathway Omphalia lapidescens

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