检索结果-南通市图书馆

Preliminary molecular basis of danggui-buxue-tang on Qi deficiency and blood stasis syndrome

沈阳药科大学学报 2008年第S1期25卷 110-111页

作者： LIU Ya,LI Xiao-hui(Institute of Materia Medica,College of Pharmacy,Third Military Medical University,Chongqing 400038,China)

Objective To study the molecular biology mechanism of danggui-buxue-tang on tonifying Qi and controlling blood circulation through modulation the immune functional *** Rats were randomly divided into control group,model group,and danggui-buxue-tang *** of dang-guibuxue-tang on mRNA expressions of IL-1β,TNF-α,HSP-70,NF-κB,p38MAPK and JNK in blood cells of rats with Qi deficiency and blood stasis were measured with real-time fluorescent quantitative-PCR at 5th,14th and 28th *** that in artery wall were determined at the 28th ***-κB/p65 and p-c-jun protein expressions in rat artery wall were detected by western blotting as *** In model group,TNF-α,IL-1β,NF-κB,HSP-70,p38MAPK and JNK mRNA expression in blood cell increased significantly compared with control *** with model group,mRNA expression of IL-1βand JNK decreased significantly;TNF-α decreased at 5th,14th day;HSP-70,p38MAPK decreased at 14th,28th day;NF-κB decreased at 28th *** model group,TNF-α,IL-1β,NF-κB,p38MAPK and JNK mRNA expression in artery increased compared with control group,excluded HSP-70,and that in danggui-buxue-tang group decreased *** model group,NF-κB/p65 and p-c-jun protein expression in artery increased compared with control group,and that in danggui-buxue-tang group decreased *** The effects of dang-guibuxue-tang on Qi deficiency and blood stasis syndrome was brought from the regulating of cytokine network at multi-link and multi-target,NF-κB,p38MAPK and JNK signal transduction pathways *** which the immune system and whole body reached to a functional balance status.

关键词： qi deficiency and blood stasis dang-guibuxue-tang cytokine network immunity signal transduction pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preliminary molecular basis of danggui-buxue-tang on Qi deficiency and blood stasis syndrome

Preliminary molecular basis of Danggui-buxue-tang on Qi defi...

引用

两岸三地药理学与临床药理学术会议

作者： LIU Ya LI Xiao-hui (Institute of Materia Medica, College of Pharmacy, Third Military Medical University, Chongqing 400038, China)

Objective To study the molecular biology mechanism of danggui-buxue-tang on tonifying Qi and controlling blood circulation through modulation the immune functional *** Rats were randomly divided into control group,model group,and danggui-buxue-tang *** of dang-guibuxue-tang on mRNA expressions of IL-1β,TNF-α,HSP-70,NF-κB,p38MAPK and JNK in blood cells of rats with Qi deficiency and blood stasis were measured with real-time fluorescent quantitative-PCR at 5th,14th and 28th *** that in artery wall were determined at the 28 ***-κB/p65 and p-c-jun protein expressions in rat artery wall were detected by western blotting as *** In model group,TNF-α,IL-1β,NF-κB, HSP-70,p38MAPK and JNK mRNA expression in blood cell increased significantly compared with control *** with model group,mRNA expression of IL-1βand JNK decreased significantly;TNF-αde- creased at 5th,14th day;HSP-70,p38MAPK decreased at 14th,28th day;NF-κB decreased at 28th *** model group,TNF-α,IL-1β,NF-κB,p38MAPK and JNK mRNA expression in artery increased compared with control group,excluded HSP-70,and that in danggui-buxue-tang group decreased *** model group,NF-κB/p65 and p-c-jun protein expression in artery increased compared with control group, and that in danggui-buxue-tang group decreased *** The effects of dang-guibuxue- tang on Qi deficiency and blood stasis syndrome was brought from the regulating of cytokine network at multi-link and multi-target,NF-κB,p38MAPK and JNK signal transduction pathways *** which the immune system and whole body reached to a functional balance status.

关键词： qi deficiency and blood stasis dang-guibuxue-tang cytokine network immunity signal transduction pathway

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：