检索结果-南通市图书馆

Dendritic cell-mimicking scaffolds for ex vivo t cell expansion

Bioactive Materials 2023年第3期21卷 241-252页

作者： Hye Sung Kim tzu-Chieh Ho Moshe J.Willner Michael W.Becker Hae-Won Kim Kam W.Leong Department of Biomedical Engineering Columbia UniversityNew YorkNYUSA Institute of tissue Regeneration Engineering Dankook UniversityCheonanRepublic of Korea Wilmot Cancer Institute University of Rochester Medical CenterRochesterNYUSA Department of Regenerative Dental Medicine College of DentistryDankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonanRepublic of Korea Department of Systems Biology Columbia University Irving Medical CenterNew YorkNY10032USA

We propose an ex vivo t cell expansion system that mimics natural antigen-presenting cells(APCs)for adoptive cell therapy(ACt).Microfiber scaffolds coated with dendritic cell(DC)membrane replicate physicochemical properties of dendritic cells specific for t cell activation such as rapid recognition by t cells,long duration of t cell tethering,and DC-specific co-stimulatory *** DC membrane-coated scaffold is first surface-immobilized with t cell stimulatory ligands,anti-CD3(αCD3)and anti-CD28(αCD28)antibodies,followed by adsorption of releasable interleukin-2(IL-2).the scaffolds present both surface and soluble cues to t cells ex vivo in the same way that these cues are presented by natural APCs in *** demonstrate that the DC-mimicking scaffold promotes greater polyclonal expansion of primary human t cells as compared toαCD3/αCD28-func-tionalized *** importantly,major histocompatibility complex molecules derived from the DC membrane of the scaffold allow antigen-specific t cell expansion with target cell-specific killing *** addition,most of the expanded t cells(~97%)can be harvested from the scaffold by density gradient ***,the DC-mimicking scaffold offers a scalable,modular,and customizable platform for rapid expansion of highly functional t cells for ACt.

关键词： Adoptive cell therapy Ex vivo t cell expansion cytotoxic t cell Dendritic cell membrane cell membrane coating Scaffold

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human cancergermlineantigen-specific cytotoxictcell-what canwelearnfrompatient

引用

cellular & Molecular Immunology 2020年第7期17卷 684-692页

作者： Megat Abd Hamid Yanchun Peng tao Dong Nufield Department of Medicine Chinese Academy of Medical Science Oxford Institute(COI)University of OxfordOxfordUK MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineUniversity of OxfordOxfordUK

In this review,we will highlight the importance of cancer germline antigen-specific cytotoxic CD8^(+) t lymphocytes(CtL)and the factors affecting antitumor CtL *** light of cancer immunotherapy,we will emphasis the need to further understand the features,characteristics,and actions of modulatory receptors of human cancer germline-specific CtLs,in order to determine the optimal conditions for antitumor CtL responses.

关键词： cytotoxic t cell immune check point receptor immune therapy t cell receptor cancer antigen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：