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Suppression of renal cell proliferation, induction of apoptosis and cell cycle arrest: Cytotoxicity of vanadium in broilers

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Health 2012年第2期4卷 101-107页

作者： Xiaodong Liu Hengmin Cui Xi Peng Jing Fang Wei Cui Bangyuan Wu Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province College of Veterinary Medicine Sichuan Agricultural University Sichuan China

The aims of this study were to clarify the effects of high vanadium on the renal cell cycle and apoptosis in broilers. 420 one-day-old avian broilers were divided into six groups and fed on a control diet (vanadium 0.073 mg/kg), and five high vanadium diets (vanadium 5 mg/kg, high vanadium group I;15 mg/kg, high vanadium group II;30 mg/kg, high vanadium group III;45 mg/kg, high vanadium group IV;60 mg/kg, high vanadium group V) throughout the experimental period of 42 days. As tested by flow cytometry, the percentage of apoptotic renal cells was increased in high vanadium group II, III, IV and V when compared with that of control group. The Proliferating index (PI) of renal cell and the ratio of S, G2 + M phase cells were markedly decreased and population of G0/G1 cells was increased in high vanadium group II, III, IV and V. The results showed that dietary vanadium in excess of 15 mg/kg was toxic to kidney by the renal cells cycle arrest and increased apoptosis, which caused the growth depression of the kidney in broilers.

关键词： Dietary High Vanadium Renal Cells Apoptosis Cell Cycle Flow cytometry (FCM) Broiler

Effects of integrin-targeted photodynamic therapy on pancreatic carcinoma cell

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China Medical Abstracts(Internal Medicine) 2013年第2期30卷 105-106页

作者：倪倩雯 Dept Digest Endosc Diagn Treat Xinhua HospAffill Shanghai Jiaotong Univ Sch Med

Objective To investigate the anti-carcinoma role ofintegrin targeted photodynamic therapy(PDT)on pancreatic carcinoma cells in *** Pancreatic carcinoma cells SW 1990 were divided into

关键词： targeted photodynamic integrin targeting cytometry tetrazolium confocal inducing thiazolyl arginine

Levels of IL-17 and Th17/Treg ratio reflect clinical and pathological activity in patients with lupus nephritis

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China Medical Abstracts(Internal Medicine) 2014年第2期31卷 115-116页

作者：许嵘 Dept Nephrol Zhongshan HospFudan Univ

Objective To explore the correlation of Th17/Treg ratio and related cytokines with clinical and pathological activity in patients with lupus nephritis(LN).Methods The patients with lupus nephritis were enrolled into this study from June 2011 to Feb *** demographic data,clinical activity and pathological index were recorded and analyzed in *** frequency of Th17 and

关键词： nephritis details cytokines demographic enrolled indicator cytometry dsDNA inactive evaluating

The development and characterization ot recombinant adenovirus encoding RA538, p53 or p16 for gene therapy of cancer

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中国实验血液学杂志 1997年第3期5卷 331-332页

作者： Jinke Cheng, Chen Lin, Xueyan Zhang, Rong Xing, Juwei Mu, Min WuNational Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100021

We have constructed three recombinantadenoviruses encoding RA538, p53 or p16 respec-tively. These recombinant adenoviruses are able toexpress RA538, p53 or p16 in infected human cancercells. The transduction efficiency assay showed thatthe infected cancer cells inoculated with theserecombinant adenoviruses at MOI of 25 or greaterexhibited 100% transduction efficiency. The growthrates and colony formation of cancer cells infectedwith these recombinant adenoviruses were

关键词： adenovirus encoding infected transduction cytometry inoculated colony subcutaneous nude arrest

Correlation between myeloid-derived suppressor cells and gastric cancer begin with chronic gastritis

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China Medical Abstracts(Internal Medicine) 2012年第4期29卷 221-222页

作者：朱立宁 Dept Gastroenterol Affil HospJiansu Univ

Objective To investigate the correlation between the ratio change of circulating myeloid-derived suppressor cells(MDSCs) and cellular immune function in healthy volunteers,chronic gastritis patients,gastric intraepith... 详细信息

关键词： gastritis myeloid suppressor neoplasia Correlation circulating lymphocyte cytometry begin statistically

The immunophenotypic and clinical characteristics analysis of NPM1 mutated acute myeloid leukemia

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China Medical Abstracts(Internal Medicine) 2013年第2期30卷 122-123页

作者：刘艳荣 Instit Hema-tol People's HospPeking Univ

Objective To compare the immunophenotypic and clinical characteristics between NPM1mutated acute myeloid leukemia(AML)(NPM1m+AML)and unmutated AML(NPM1m-AML)not otherwise characterized(NOS)

关键词： myeloid otherwise mutated lymphocytic remission cytometry lymphoid presentation progenitor constituent

Effect of adrenomedullin on rat renal tubular epithelial cell apoptosis induced by hypoxiareoxygenation and its mechanism

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China Medical Abstracts(Internal Medicine) 2013年第3期30卷 180-181页

作者：苏晓乐 Dept Nephrol 2nd HospShanxi Med Univ

Objective To investigate the effect of adrenomedullin on rat renal tubular epithelial cell line (NRK-52E) apoptosis induced by hypoxia-reoxygenation (HR) injury and its *** NRK-52E cells were cultured and randomly all... 详细信息

关键词： tubular plasmid cytometry transfection cultured empty dehydrogenase Caspase lactate inhibiting

Morphological Study on the Mechanism of Tumor-selective Cytocidal Action of Tumor Necrosis Factor

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Journal of Medical Colleges of PLA(China) 1989年第3期4卷 200-204页

作者：阎伦飙何德华张璞 Department of Pathology Second Military Medical University Shanghai

Using light microscopy and electron microscopy, we observed the morphological changes inheuman hepatocellular carcinoma cell line (SMMC-7721) treated with tumor necrosis tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma. It wasfound that the changes of the injury occurred earlier in the cell membranes than in the nuclei duringthe course of TNF killing of SMMC-7721 cells and there were similar lesions around the necroticarea in the heterotransplanted human hepatocellular carcinoma in the nude mice as compared withthose produced in SMMC-7721 cells. In addition, the determination of the DNA content in TNF-treated SMMC-7721 cells and controls revealed no significant difference between them. On the basisof these results and Darzynkiewicz’s proposals, it is suggested that TNF exerts its tumor-selectivekilling effect by binding to a specific to a specific plasma membrane receptor to disturb synthesis or assembly ofcell membrane components, thus causing the plasma membrane injury and finally cell lysis.

关键词： tumor necrosis factor human hepatocellular carcinoma cell line heterotransplanted tumor electron microscopy flow cytometry

Respiratory System Respiratory tract tumor

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China Medical Abstracts(Internal Medicine) 2009年第3期26卷 152-153页