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cytokines that target immune killer cells against tumors

Cellular & Molecular Immunology 2020年第7期17卷 722-727页

作者： Jian Qiao Yang-Xin Fu The Department of Pathology University of Texas Southwestern Medical CenterDallasTX 75235USA

T-cell-stimulating cytokines have shown promise as monotherapies or in combination with other therapeutic modalities for immunotherapy of ***,their efficacy is limited due to their short half-life,pleiotropic roles,and induction of severe toxicity even at therapeutic *** overcome these major therapeutic barriers,cytokine-based products are being further developed to improve their therapeutic *** approaches include manipulating their activity to preferentially bind to effector immune cells rather than immune-suppressive cells,prolonging their half-life in vivo and modifying them to target *** review focuses on IL-2,IL-15,and IL-10,which have potent effects on immune cells that mediate effective antitumor *** will summarize the recent progress of these cytokines in both preclinical studies and selective clinical applications and will discuss our perspectives on the development of new strategies to potentiate cytokine-based immunotherapy.

关键词： IL-2 IL-15 IL-10 cytokine therapy cancer

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Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 215-224页

作者： Keun-Yeong Jeong Research and Development Center PearlsinMiresSeoul 03690South Korea

With the establishment of the immune surveillance mechanism since the 1950s,attempts have been made to activate the immune system for cancer treatment through the discovery of various cytokines or the development of antibodies up to *** fruits of these efforts have contributed to the recognition of the 3rd generation of anticancer immunotherapy as the mainstream of cancer ***,the limitations of cancer immunotherapy are also being recognized through the conceptual establishment of cold tumors recently,and colorectal cancer(CRC)has become a major issue from this therapeutic point of ***,it is emphasized that non-clinical strategies to overcome the immunosuppressive environment and clinical trials based on these basic investigations are being made on the journey to achieve better treatment outcomes for the treatment of cold CRC.

关键词： Colorectal cancer Immunotherapy Cell therapy Checkpoint inhibitor Cancer vaccine cytokine therapy

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A concise review of immunotherapy for glioblastoma

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Neuroimmunology and Neuroinflammation 2018年第6期5卷 18-28页

作者： Omer Sager Ferrat Dincoglan Selcuk Demiral Bora Uysal Hakan Gamsiz Bahar Dirican Murat Beyzadeoglu Department of Radiation Oncology University of Health SciencesGulhane Medical FacultyAnkara 06018Turkey

Glioblastoma(GB)is the most common and aggressive form of primary brain tumors in adults with a universally poor prognosis despite multimodal management including surgery,chemotherapy and radiation *** the novel therapeutic strategies,immunotherapy deserves particular attention with its potential to evoke biologic response and harness the host immune *** success achieved for other tumors has elicited great enthusiasm and prompted research on immunotherapy for *** the central nervous system has traditionally been thought of as an immune-privileged site,our understanding is being refined with emerging *** studies have been conducted and more are under way to establish the role of immunotherapy in management of *** of GB has yet resulted in mixed success with conflicting research findings,emphasizing the need for extensive study before its integration into routine clinical *** there is a lot of room for improvement,immunotherapy for GB may be feasible and serve as a viable management strategy broadening and strengthening the therapeutic armamentarium to combat this deadly ***,we present a concise review of immunotherapy for GB.

关键词： Glioblastoma immunotherapy glioma vaccine passive immunotherapy active immunotherapy cytokine therapy central nervous system

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