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Meta-analysis of cytochrome p4501a1 MspI Gene polymorphism and Childhood Acute Leukemia

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Biomedical and Environmental Sciences 2011年第6期24卷 683-687页

作者： ZHANG Yao Dong TAN Li Na ZHANG Xiao Ling WEI Hai Yan XIONG Hao HU Qun Department of Endocrinology Zhengzhou Children＇s Hospital Zhengzhou 450053 Henan China Department of Cardiothoracic Surgery Zhengzhou Children＇s Hospital Zhengzhou 450053 Henan China Department of pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China Department of Hematology Wuhan Children＇s Hospital Wuhan 430016 Hubei China

Objective To investigate the relationship between cytochrome p4501a1 （CYpIA1） Msp I gene polymorphism and childhood acute leukemia （AL）. Methods Relevant literature was extensively searched and screened by pubmed and Wanfang Database, Chinese Science Journal Database and Chinese Journal Net. Various data consolidation, combined OR values and their 95% CI were tested by RevMan 4.2; Funnel plots were used for the bias analysis. Results Six related literatures were found to meet the requirements. According to heterogeneity results, there was no significant difference in homozygous types（p〉0.05）, while there was significant difference in two others types （p all〈0.05）. For wild CYpIAIMspl homozygous for the reference group, Combined OR of heterozygous mutation, homozygous, heterozygous ＋ homozygous mutation in AL and control groups were 1.18, 0.96, and 1.10 respectively. Subgroup analysis： Z values of CYp1A1Mspl homozygous, heterozygous ＋ homozygous in the acute lymphoblastic leukemia （ALL） and the control group were 0.10 and 0.76 respectively, Z values in non-acute lymphoblastic leukemia and control group were 0.74 and 0.75. Conclusion There is no correlation between CYp1A1Mspl gene polymorphism and the susceptibility of childhood AL.

关键词： Acute leukemia cytochrome p4501a1 Genetic polymorphism Meta-analysis

The benzo(a) pyrene-induced mRNA expression of aromatic hydrocarbon receptor and cytochrome p4501a1 genes in rat liver

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Journal of pharmaceutical Analysis 2010年第1期22卷 30-33页

作者： Fu-Hou Chang,Qin Yin,Jun Qi,Min-Jie Wang,Lei Fan,Rui-Lan Han Department of pharmacology,Inner Mongolia Medical College,Huhhot 010059,China Department of pharmacology Inner Mongolia Medical College Huhhot 010059 China

Objective To study the benzo(a)pyrene(B[a]p)-induced mRNA expression of aromatic hydrocarbon receptor(AHR)and cytochrome p4501a1(CYp1A1)genes in rat *** Rats were injected intraperitoneally with 5,10 and 15mg/kg of B[a]*** total RNAs were extracted from rat livers by RNA purification kit,and the mRNA expression of AHR and CYp1A1 genes was determined by reverse transcription polymerase chain reaction(RT-pCR).β-actin was used as the internal *** mRNA expression of both AHR and CYp1A1 genes was measured at indicated time points(24,48 and 72h)after B[a]p treatment at three different concentrations(5,10 and 15mg/kg).Results The mRNA expression of AHR gene increased in a time-dependent manner at the concentration of 10mg/kg but not at 5 and 15mg/kg of B[a]*** mRNA expression of CYp1A1 gene differed significantly at 48h and 24h in rat livers treated with 10 and 15mg/kg dosage of B[a]*** mRNA expression of AHR and CYp1A1 genes increased with B[a]p treatment in a concentration-dependent *** time-dependent increase in mRNA expression was shown by AHR but not by CYp1A1 gene with B[a]p(10mg/kg)*** This study demonstrates that toxic B[a]p increases the mRNA expression of both AHR and CYp1A1 genes in vivo,suggesting that B[a]p may play a role in cancer genesis by this way.

关键词： benzo(a)pyrene aromatic hydrocarbon receptor cytochrome p4501a1 gene expression

Single-cell RNA-seq unveils critical regulators of human FOXp3^+regulatory T cell stability

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Science Bulletin 2020年第13期65卷 1114-1124,M0004页

作者： Gang Yi Yi Zhao Feng Xie Fuxiang Zhu Ziyun Wan Jingwan Wang Xie Wang Kai Gao Lixia Cao Xinyang Li Chen Chen Yashu Kuang Xiu Qiu Huanming Yang Jian Wang Bing Su Lei Chen Wei Zhang Yong Hou Xun Xu Yinyan He Andy Tsun Xiao Liu Bin Li Shanghai Institute of Immunology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Immunology and Microbiology Shanghai Jiao Tong University School of MedicineShanghai 200025China BGI-Shenzhen Shenzhen 518083China School of Biology and Biological Engineering South China University of TechnologyGuangzhou 510006China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Obstetrics and Gynaecology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Division of Birth Cohort Study Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510006China James D.Watson Institute of Genome Sciences Hangzhou 310058China Biotheus Inc. Zhuhai 519080China

The heterogeneity and plasticity of T lymphocytes is critical for determining immune response *** regulatory T(Treg)cells are commonly characterized by stable FOXp3 expression and have reported to exhibit heterogeneous phenotypes under inflammatory ***,the interplay between inflammation and Treg cell suppressive activity still remains ***,we utilized singlecell RNA sequencing to investigate how human Treg cells respond to the pro-inflammatory cytokine interleukin-6(IL-6).We observed that Treg cells divided into two subpopulations after IL-6 ***àunstable Treg cells lost FOXp3 expression and gained an effector-like T cell phenotype,whereas TIGIT+Treg cells retained robust suppressive *** cell transcriptome analysis revealed a spectrum of cellular states of IL-6-stimulated Treg cells and how cytochrome p450 family 1 subfamily A member 1(CYp1A1)is a crucial regulator of Treg cell suppressive capability and ***1A1-deficient human Treg cells developed a Th17-like phenotype after IL-6 *** findings implicate CYp1A1 as a previously unidentified regulator of Treg cells that may have target potential for clinical application for biotherapies.

关键词： Treg cell scRNA-seq Inflammation Interleukin-6 Heterogeneity cytochrome p4501a1

Application of CRS-pCR-RFLp to identify CYp1A1 gene polymorphism

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Application of CRS-PCR-RFLP to identify CYP1A1 gene polymorp...