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GSTT1,GSTM1 and cyp2e1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

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World Journal of Gastroenterology 2004年第9期10卷 1240-1245页

作者： Jucimara Colombo Ana elizabete Silva Andréa Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wohnrath Departamento de Biologia UNESP-Campus de So José do Rio Preto-SPBrazil Departamento de Doencas Dermatológicas Infecciosas e ParasitáriasFaculdade de MedicinaFAMERPSo José do Rio PretoSPBrazil Hospital de Base Faculdade de MedicinaFAMERE So José do Rio PretoSPBrazil Fundaco pio Ⅻ BarretosBrazil

AIM:To test the hypothesis that,in the Southeastern Brazilian population,the GSTT1,GSTM1 and cyp2e1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer. MeTHODS:We conducted a study on 100 cases of gastric cancer (GC),100 cases of chronic gastritis (CG),and 150 controls (C).Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex ***2e1/pst1 genotyping was performed using a pCR-RFLp assay. ReSULTS:No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of cyp2e1 was observed among the three ***,a significant difference between CG and C was observed,due to a greater number of GSTT1/GSTM1 positive genotypes in the CG *** GSTT1 null genotype occurred more frequently in Negroid subjects,and the GSTM1 null genotype in Caucasians,while the GSTM1 positive genotype was observed mainly in individuals with chronic gastritis infected with H pylori. CONCLUSION:Our findings indicate that there is no obvious relationship between the GSTT1,GSTM1 and cyp2e1 polymorphisms and gastric cancer.

关键词： polymorphism, Genetic Adolescent Adult Aged Aged, 80 and over Brazil Case-Control Studies Chronic Disease cytochrome p-450 cyp2e1 Female Gastritis Genotype Glutathione Transferase Humans Male Middle Aged Research Support, Non-U.S. Gov't Risk Factors Stomach Neoplasms

cyp1A1,cyp2e1 and epHX1 polymorphisms in sporadic colorectal neoplasms

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World Journal of Gastroenterology 2016年第45期22卷 9974-9983页

作者： Glaucia Maria M Fernandes Anelise Russo Marcela Alcantara proenca Nathalia Fernanda Gazola Gabriela Helena Rodrigues patrícia Matos Biselli-Chicote Ana elizabete Silva Joao Gomes Netinho érika Cristina pavarino eny Maria Goloni-Bertollo Genetics and Molecular Biology Research Unit-UpGeM Department of Molecular Biology Sao José do Rio Preto Medical School FAMERP Departament of Biology UNESP-Sao Paulo State University Departament of Surgery and Coloproctology Service Sao José do Rio Preto Medical School FAMERP

AIM To investigate the contribution of polymorphisms in the cyp1A1, cyp2e1 and epHX1 genes on sporadic colorectal cancer(SCRC) risk. MeTHODS Six hundred forty-one individuals(227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The cyp1A1 *2A, cyp1A1 *2C cyp2e1 *5B and cyp2e1 *6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism(pCR-RFLp). The epHX1 Tyr113 His, epHX1 His139 Arg and cyp1A1 *2C polymorphisms were detected by real-time pCR. Chisquared test and binary logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the Haploview program, version *** Age over 6 2 years was a risk factor for SCRC development(OR = 7.54, 95%CI: 4.94-11.50, p 1). Male individuals were less susceptible to SCRC(OR = 0.55, 95%CI: 0.35-0.85, p 1). The cyp2e1*5B polymorphism was associated with SCRC in the codominant(heterozygous genotype: OR = 2.66, 95%CI: 1.64-4.32, p 1), dominant(OR = 2.82, 95%CI: 1.74-4.55, p 1), overdominant(OR = 2.58, 95%CI: 1.59-4.19, p 1), and log-additive models(OR = 2.84, 95%CI: 1.78-4.52, p 1). The cyp2e1*6 polymorphism was associated with an increased SCRC risk in codominant(heterozygous genotype: OR = 2.81, 95%CI: 1.84-4.28, p 1; homozygous polymorphic : OR = 7. 3 2, 9 5 % C I : 1.85-28.96, p 1), dominant(OR = 2.97, 95%CI: 1.97-4.50, p 1), recessive(OR = 5.26, 95%CI: 1.35-20.50, p = 0.016), overdominant(OR = 2.64, 95%CI: 1.74-4.01, p 1), and log-additive models(OR = 2.78, 95%CI: 1.91-4.06, p 1). The haplotype formed by the minor alleles of the cyp2e1*5B(C) and cyp2e1*6(A) polymorphisms was associated with SCRC(p = 0.002). However, the cyp1A1 *2A, cyp1A1 *2C, epHX1 Tyr113 His and epHX1 His139 Arg polymorphisms were not associated with *** In conclusion, the

关键词： Single-nucleotide polymorphisms Colorectal neoplasms cytochrome p-450 cyp2e1 cytochrome p-450 cyp1A1 epoxide hydrolases 1

cytochrome p450 2e1 genetic polymorphism and gastric cancer in Changle,Fujian province

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World Journal of Gastroenterology 2001年第6期7卷 792-795页

作者： Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of epidemiology,Fujian Medical University,Fuzhou 350004,Fujian province,China2 Department of epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of epidemiology,UCLA School of public Health,Los Angeles California,USA Department of epidemiology Fujian Medical University Fuzhou 350004 Fujian Province China. zjcailin@***

AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. cytochrome p450 2e1 (cyp2e1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitrosoamines and low molecular weight organic compounds. The purpose of this study is to determine whether cyp450 2e1 polymorphisms are associated with risks of gastric cancer. MeTHODS: We conducted a population based case-control study in Changle county, Fujian province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including demographic characteristics, diet intake, and alcohol and tobacco consumption of individuals in our study were completed by a standardized ***-RFLp revealed three genotypes:heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in cyp2e1. ReSULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 individuals in gastric cancer group(6.6%), whereas there was only one in the control group (1.1%). However, there was no statistically significant difference between the two groups (two-tailed Fisher's exact test p=0.066). Individuals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR=1.50) and C2/C2 (OR=7.34) than individuals in control group (chi(2) =4.597, for trend p=0.032). The frequencies of genotypes with the C2 allele (C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele (C1/C1 genotype) among individuals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that individuals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer. CONCLUSION: poly

关键词： polymorphism, Genetic Aged Asian Continental Ancestry Group Case-Control Studies China cytochrome p-450 cyp2e1 Female Gene Frequency Genetic predisposition to Disease Humans Male Middle Aged Research Support, Non-U.S. Gov't Stomach Neoplasms

polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand

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World Journal of Gastrointestinal pathophysiology 2023年第2期14卷 21-33页

作者： Gyokukou You Lu Zeng Hideaki Tanaka emi Ohta Takahiro Fujii Kazuhiko Ohshima Masakazu Tanaka Nobuyuki Hamajima Chutiwan Viwatthanasittiphong Mantana Muangphot Dhiraphol Chenvidhya Adisorn Jedpiyawongse Banchob Sripa Masanao Miwa Satoshi Honjo Department of Bioscience Nagahama Institute of Bio-Science and TechnologyNagahama 526-0829ShigaJapan Division of Neuroimmunology Joint Research Center for Human Retrovirus InfectionKagoshima UniversityKagoshima 890-8544KagoshimaJapan Department of Healthcare Administration Nagoya University Graduate School of MedicineNagoya 466-8550AichiJapan Department of Diagnostic and Interventional Radiology Ubon Cancer CentreUbon Ratchathani 34000Thailand Department of pathology Ubon Cancer CentreUbon Ratchathani 34000Thailand Department of Surgery Ubon Cancer CentreUbon Ratchathani 34000Thailand Research Division National Cancer InstituteBangkok 10400Thailand Department of pathology Khon Kaen UniversityKhon Kaen 40002Thailand Department of paediatirics National Hospital OrganizationFukuoka National HospitalFukuoka 811-1394FukuokaJapan

BACKGROUND Cholangiocarcinoma(CCA)is an intractable cancer,and its incidence in north eastern Thailand is the highest *** with the liver fluke Opisthorchis viverrini(OV)has been associated with CCA ***,animal experiments have suggested that OV alone does not induce CCA,but its combination with a chemical carcinogen like nitrosamine can cause experimentally induced CCA in ***,in humans,other environmental and genetic factors may also be *** To examine relations between risk for CCA and genetic polymorphisms in carcinogenmetabolizing and inflammation-related *** This hospital-based case-control study enrolled 95 case-control pairs matched by age(±5 years)and *** examined relations between risk for CCA and genetic polymorphisms in carcinogenmetabolizing and inflammation-related genes,serum anti-OV,alcohol consumption,and *** of cyp2e1,IL-6(-174 and-634),IL-10(-819),and NF-κB(-94)and their cooccurrence with polymorphisms in the drug-metabolizing enzyme gene GSTT1 or GSTM1 were also *** Although CCA risk was not significantly associated with any single polymorphism,persons with the GSTT1 wild-type and cyp2e1 c1/c2+c2/c2 genotype had an increased risk(OR=3.33,95%CI:1.23-9.00)as compared with persons having the GSTT1 wild-type and cyp2e1 c1/c1 wild *** presence of anti-OV in serum was associated with a 7-to 11-fold increased risk,and smoking level was related to an OR of 1.5-1.8 in multivariable analyses adjusted for each of the seven genetic *** In addition to infection with OV,gene-gene interactions may be considered as one of the risk factors for CCA development.

关键词： Opisthorchis Glutathione transferase cytochrome p-450 cyp2e1 Case-control study