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cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer

World Journal of Gastroenterology 2014年第4期20卷 968-977页

作者： Sayeh Savari Katyayni Vinnakota Yuan Zhang Anita Sjlander Division of Cell and Experimental Pathology Department of Laboratory Medicine Lund University Skne University Hospital

Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies.A complex milieu composed of distinct stromal and immune cells,soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of *** augmented inflammatory response can predispose a patient to colorectal cancer(CRC).Common risk factors associated with CRC development include diet and lifestyle,altered intestinal microbiota and commensals,and chronic inflammatory bowel *** leukotrienes are potent inflammatory metabolites synthesized from arachidonic acid and have a broad range of functions involved in the etiology of various *** review discusses the important role of cysteinyl leukotriene signaling in linking inflammation and CRC.

关键词： Eicosanoids cysteinyl leukotrienes CysLT1R CysLT2R Inflammation Colorectal cancer

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Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第3期4卷 162-168页

作者： Tanya M. Laidlaw Brigham and Women’s Hospital Division of RheumatologyImmunology and AllergyBostonMAUSA Harvard Medical School BostonMAUSA

It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter’s disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms, which usually in-volves nasal congestion, rhinorrhea, wheezing and bronchospasm. Gastrointestinal distress, nausea, a pruritic rash and angioedema can also occasionally develop. However, the underlying pathologic mechanism that drives these clinical reactions remains elusive. Pretreatment with medications that inhibit the leukotriene pathway decreases the severity of clinical reactions, which points to the involvement of cysteinyl leukotrienes (cysLTs) in the pathogenesis of these aspirin-induced reactions. Furthermore, studies of aspirin challenges in carefully-phenotyped patients with AERD have confirmed that both proinflammatory lipid mediators, predominantly cysLTs and prostaglandin (PG) D 2, and the influx of effector cells to the respiratory tissue, contribute to symptom development during aspirin-induced reactions. Mast cells, which have been identified as the major cellular source of cysLTs and PGD 2, are likely to be major participants in the acute reactions, and are an attractive target for future pharmacotherapies in AERD. Although several recent studies support the role of platelets as inflammatory effector cells and as a source of cysLT overproduction in AERD, it is not yet clear whether platelet activation plays a direct role in the development of the aspirin-induced reactions. To further our understanding of the pathogenesis of aspirin-induced reactions in AERD, and to broaden the pharmacotherapeutic options available to these patients, additional investigations with targeted clinical trials will be required.

关键词： Aspirin-exacerbated respiratory disease(AERD) Nasal polyps Samter’s triad Pathogenesis cysteinyl leukotrienes Prostaglandins Mast cell

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Exposure to extremely low-frequency electromagnetic fields inhibits T-type calcium channels in HEK293 cells

Exposure to extremely low-frequency electromagnetic fields i...

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中国神经科学学会第十届全国学术会议

作者： Yu-Jie CUI Chang-Long HU Institutes of Brain Science School of Life Sciences and State Key Laboratory of Medical NeurobiologyFudan University

The modulation of a variety of ion channel activities by extremely low-frequency electromagnetic fields（ELF-EMF） has been reported previously,few reports have researched the effects of ELF-EMF on the activity of voltage-activated T-type calcium *** this report,we investigated the effects of ELF-EMF on all three subtypes of T-type calcium channels transfected in HEK293 *** results demonstrate that the exposure of HEK293 cells to ELF-EMF for 60 min significantly decreased the currents of T-type calcium channels（31%）,time-dependent patterns have been observed *** phenomenon is very similar to the effect of intracellular application of arachidonic acid（AA） on currents of T-type calcium channels in HEK293 *** increases in intracellular AA（15.4%） and extracellular cysteinyl leukotrienes（31%） were observed following ELF-EMF *** blottings indicated that the total expression levels of T-type calcium channel protein were not affected after exposure to ELF-EMF.5-lipoxygenase inhibitors were able to ehminate this ELF-EMF-induced decrease in T-type calcium channel *** addition,perfusion of CysLTs significantly inhibited the currents of T-type calcium channels.

关键词： extremely low-frequency electromagnetic fields T-type calcium channel currents cysteinyl leukotrienes HEK293 Cells

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