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Cyr61/CTGF/Nov family proteins in gastric carcinogenesis

World Journal of Gastroenterology 2014年第7期20卷 1694-1700页

作者： Tsu-Yao Cheng Ming-Shiang Wu Kuo-Tai Hua Min-Liang Kuo Ming-Tsan Lin Department of Laboratory Medicine National Taiwan University Hospital Department of Internal Medicine National Taiwan University Hospital Graduate Institute of Toxicology National Taiwan University College of Medicine Department of Surgery National Taiwan University Hospital

Gastric cancer(GC)is the second leading cause of cancer-related *** poor survival rate may reflect the relatively aggressive tumor biology of ***,the importance of the tumor microenvironment in carcinogenesis has *** the tumor microenvironment,tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating *** Cyr61/CTGF/Nov(CCN)proteins are a family of matricellular proteins with variable roles in many physiological and pathological *** evidence suggests that CCN family proteins contribute to GC carcinogenic ***,we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field.

关键词： Cyr61/CTGF/Nov proteins cysteine-rich angiogenic inducer 61 Connective tissue growth factor Nephroblastoma over-expressed Gastric cancer Gastric carcinogenesis

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Cyr61 Alleviates Cholangitis by Inhibiting Cytotoxic Effects of CD8^(+) T Cells on Biliary Epithelial Cells

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Current Medical Science 2021年第6期41卷 1205-1213页

作者： Tiao-chun CHENG Han LI Xi LUO Lin-ling JU Lin CHEN Jian-guo SHAO Yong-jun SHE Min LI Zhao-lian BIAN Medical School of Nantong University Nantong 226006China Nantong Institute of Liver Disease Nantong Third People’s Hospital Nantong UniversityNantong 226006China Department of Gastroenterology and Hepatology Nantong Third People’s HospitalNantong UniversityNantong 226006China Department of Anesthesiology Nantong Third People’s HospitalNantong UniversityNantong 226006China

Objective:Primary biliary cholangitis(PBC)is a chronic progressive cholestatic liver *** recent years,researchers have found that cysteine-rich angiogenic inducer 61(Cyr61,also known as CCN1)has a potential role in reducing portal inflammation in patients with *** study aimed to explore the relationship between Cyr61 and PBC to provide new ideas and an experimental basis for the clinical treatment of ***:After induction of the overexpression of Cyr61 in a mouse model of PBC using recombinant adenovirus,hematoxylin and eosin staining and pathological scores were used to indicate intrahepatic inflammation and bile duct ***-time PCR was used to detect changes in inflammation-related cytokines in the *** further study the mechanism,we assessed whether Cyr61 protects bile duct epithelial cells from cytotoxic ***:Serum and hepatic Cyr61 levels were increased in the murine model of *** of Cyr61 alleviated hepatic inflammation and bile duct injury in ***61 inhibited the cytotoxic effects of CD8^(+)T cells by acting on biliary epithelial cells(BECs)in ***:Our results provide novel insight into the pathogenesis of PBC and suggest that Cyr61 plays a dominant role in the cytotoxic effects on BECs in ***,therapeutic strategies targeting Cyr61 could be a potent therapy for PBC.

关键词： cysteine-rich angiogenic inducer 61 primary biliary cholangitis inflammation bile duct damage cytotoxicity

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Stretch-induced Expression of CYR61 Increases the Secretion of IL-8 in A549 Cells via the NF-κβ/Iκβ Pathway

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Current Medical Science 2018年第4期38卷 672-678页

作者： Yan ZHANG Ping GUI Shang-long YAO Dong YANG Yang LV De-fang DING Department of Anaesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Pain Medicine Wuhan Pu-Ai Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430033 China

Mechanical ventilation （MV） with large tidal volumes can increase lung alveolar permeability and initiate inflammatory responses, resulting in ventilator-induced lung injury （VILI）. The mechanisms of the injurious effects of MV and the genetic susceptibility remain unclear. VILI-related genes such as cysteine-rich angiogenic inducer 61 （Cyr61） have been demonstrated to play a detrimental role in the aggressive ventilation strategies. In the present study, we investigated the involvement of Cyr61 in the VILI and the underlying mechanism. A549 cells were exposed to cyclic stretch of varying durations and then the mRNA and protein levels of Cyr61 were measured by real-time PCR and Western blotting, respectively. Additionally, after exposure ofA549 cells to cyclic stretch for 5 min to 1 h, the expression levels of nuclear factor kappaB （NF-κβ） and IL-8 were detected by ELISA and Western blotting. Thereafter, Cyr61 expression was depressed in A549 cells with the siRNA pGenesill. 1-Cyr61-3 before the cyclic stretch, and IL-8 secretion and the activation of NF- κB pathways were probed by ELISA and Western blotting, respectively. Moreover, a NF- κB inhibitor （PDTC） and an activator （TNF） were used before mechanical stretch. Realtime PCR and ELISA were performed to detect the mRNA and protein of IL-8, respectively. The results showed that the mechanical cyclic stretch led to increased Cyr61 expression at mRNA and protein levels in A549 cells. Additionally, cyclic stretch also mobilized NF- κB from the cytoplasm to the nucleus and increased IL-8 secretion in A549 cells. The inhibition of Cyr61 blocked the NF-κB activation and IL-8 secretion in response to cyclic stretch. Inhibition of NF-κB attenuated the mRNA and protein expression of IL-8 in A549 cells transfected with Cyr61 siRNA. It was suggested that Cyr61/NF-κB signaling pathway mediates the upregulation of IL-8 in response to cyclic stretch in A594 cells. These findings support the hypothesis that Cyr61 plays a critica

关键词： cysteine-rich angiogenic inducer 61 cyclic stretch lung injury

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