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Sex differentiation of effect of microinjection of somatostatin into ventrolateral orbital cortex on formalin-induced nociceptive behavior in rats

Sex differentiation of effect of microinjection of somatosta...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Chao-Ling QU~(1,*),Bo XING~2,Yong-Hui DANG~2,Yan ZHAO~2,Feng-Yi XU~1,Fu-Quan HUO~1,Jing-Shi TANG~1 1 Department of Physiology and Pathophysiology,Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education,Xi’an Jiaotong University School of Medicine,Xi’an 710061,China 2 Department of Forensic Medicine,Key Laboratory of Environment and Gene Related to Diseases,Ministry of Education, Xi’an Jiaotong University School of Medicine,Xi’an 710061,China

Objective As a neuromodulator,somatostatin(SOM) and its receptors are involved in the antinociception in the spinal cord and the supraspinal ***,sex differences are observed in some pain-related *** studies have indicated that the ventrolateral orbital cortex(VLO) is involved in modulation of nociception as part of an endogenous analgesic system consisting of the spinal cord-nucleus submedius-VLO-periaqueductal gray-spinal cord *** aim of the current study was to examine whether the SOM and its receptors are involved in the VLO-induced antinociception in the rat formalin test,and determine whether there was a sex differentiation in the formalin *** After 5%formalin (50μl) was injected subcutaneously into the plantar surface of the hindpaw,the number of times of flinching the hindpaw per 5 min was measured as an index of nociceptive response to observe the effect of microinjection of SOM into the VLO on the nociceptive behavior in different sex *** SOM(10μg/0.5μl)microinjected into the VLO significantly decreased the number of the flinches in either early or later phases in the female rat,and this inhibitory effect was blocked by pre-treatment with its antagonist cyclo-somatostatin(c-SOM,25μg/0.5μl),whereas the SOM had no effect on the formalin-induced flinching behavior in the male ***,c-SOM microinjected alone into the VLO did not influence the flinching behavior in both male and female *** These results suggest that SOM and its receptors are involved in the antinociception in the VLO of the female,but not the male rats in the formalin test.

关键词： Ventrolateral orbital cortex sex difference octreotide cyclo-somatostatin formalin test Flinching rat

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