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Expressions of cyclin E, cyclin dependent kinase 2 and p57^(KIP2) in human gastric cancer

Chinese Medical Journal 2003年第1期116卷 20-23页

作者：梁斌王杉杨晓东叶颖江于永祥崔志荣 Department of Surgery and Laboratory of Surgical Oncology

Objective To investigate the expressions of cyclin E, cyclin dependent kinase 2(CDK-2)and cyclin-dependent kinase inhibitor p57 KIP2 in human gastric cancer, and to evaluate the relationships between protein levels and clinicopathological parameters. Methods Western blot was used to measure the expressions of cyclin E, CDK-2 and p57 KIP2 proteins in the surgically resected gastric carcinoma, adjacent normal mucosa and metastatic lymph nodes from 36 patients. Results cyclin E and CDK-2 protein levels were higher in gastric cancer tissues in comparison with normal tissues (Pcyclin E was correlated with lymph node involvement, poor histological grade and serosa invasion (Pcyclin E and CDK-2 expression was found when samples were stratified according to tumor size (P>0.05). Expression of cyclin E and CDK-2 showed a positive linear correlation (r=0.451, P=0.01). Protein levels of p57 KIP2 were lower in gastric cancer tissues than in the normal mucosa (P0.05). In metastatic lymph nodes, expression of cyclin E was increased and the expression of p57 KIP2 decreased. Conclusion Overexpressions of cyclin E, CDK-2 and downregulated expression of p57 KIP2 may play important roles in tumorigenesis and metastatic potential of gastric cancer.

关键词： stomach neoplasms cyclin E cyclin dependent kinase 2 cyclin-dependent kinase inhibitor

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Downregulation of multiple CDK inhibitor ICK/KRP genes upreg...

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The ICK/KRP cyclin-dependent kinase(CDK) inhibitors are important plant cell cycle factors sharing only limited similarity with the metazoan CIP/KIP family of CDK *** is known about the specific functions of different... 详细信息

关键词： cell cycle cell size cyclin-dependent kinase inhibitor ICK/KRP leaf size plant growth RBR1 and E2F seed size

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