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Gelation capability of cysteine-modified cyclo(L-Lys-L-Lys)s dominated by Fmoc and Trt protecting groups

Science China Chemistry 2016年第3期59卷 293-302页

作者： Huimin Geng Qianying Zong Jie You Lin Ye Aiying Zhang Ziqiang Shao Zengguo Feng School of Materials Science and Engineering Beijing Institute of Technology

A series of symmetrical peptidomimetics （3-8） based on cysteine-modified cyclo（L-Lys-L-Lys）s were synthesized, and their gelation capability in organic solvents was dominated by fluorenylmethyloxycarbonyl （Fmoc） and triphenylmethyl （Trt） protecting groups and the exchange of thiol-to-disulfide as well. The peptidomimetics holding Trt （3 and 4） showed no gel performance, while the Fmoc groups promoted 5 and 6 to give rise to thermo-reversible organogels in a number of organic solvents. The self-assembled fibrillar networks were distinctly evidenced in the organogels by transmission electron micros- copy （TEM） and scanning electron microscopy （SEM） observations. Fourier transform infrared spectroscopy （FT-IR） and fluorescence analyses revealed that the hydrogen bonding and ^-rt stacking play as major driving forces for the self-assembly of these organogelators. A 13-turn secondary structure was deduced for the organogel of 6 by virtue of X-ray diffraction, FT-IR and circular dichroism （CD） measurements, and an interdigitated bilayer structure was also presented.

关键词： organogel cyclic dipeptide self-assembly cysteine β-turn

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Recent research of peptide-based hydrogel in nervous regeneration

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Bioactive Materials 2024年第10期40卷 503-523页

作者： Chunmei Xie Yueyang Chen Lang Wang Kin Liao Bin Xue Yulong Han Lan Li Qing Jiang State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Advanced Digital and Additive Manufacturing Center Khalifa University of Science and TechnologyPo Box 127788Abu DhabiUnited Arab Emirates National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjingChina State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryDrum Tower Hospital Affiliated to Medical School of Nanjing UniversityNanjingChina Jiangsu Engineering Research Center for 3D Bioprinting NanjingChina Institute of Medical 3D Printing Nanjing UniversityNanjingChina

Neurological disorders exert significantly affect the quality of life for patients,necessitating effective strategies for nerve *** traditional autologous nerve transplantation and emerging therapeutic approaches encounter scientific challenges due to the complex nature of the nervous system and the unsuitability of the surrounding environment for cell *** engineering techniques offer a promising path for *** neural tissue engineering relies on modulating cell differentiation behavior and tissue repair by developing biomaterials that mimic the natural extracellular matrix(ECM)and establish a threedimensional ***-based hydrogels have emerged as a potent option among these biomaterials due to their ability to replicate the structure and complexity of the *** review aims to explore the diverse range of peptide-based hydrogels used in nerve regeneration with a specific focus on dipeptide hydrogels,tripeptide hydrogels,oligopeptide hydrogels,multidomain peptides(MDPs),and amphiphilic peptide hydrogels(PAs).Peptide-based hydrogels offer numerous advantages,including biocompatibility,structural diversity,adjustable mechanical properties,and degradation without adverse ***,hydrogels formed from self-assembled polypeptide nanofibers,derived from amino acids,show promising potential in engineering neural tissues,outperforming conventional materials like alginate,poly(ε-caprolactone),and ***,the simple design and cost-effectiveness of dipeptidebased hydrogels have enabled the creation of various functional supramolecular structures,with significant implications for nervous system *** hydrogels are expected to play a crucial role in future neural tissue engineering *** review aims to highlight the benefits and potential applications of peptidebased hydrogels,contributing to the advancement of neural tissue engineering.

关键词： Self-assembled dipeptide cyclic dipeptide Hydrogels Nervous regeneration

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Three previously undescribed metabolites from Cordyceps cicadae JXCH-1,an entomopathogenic fungus

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Natural Products and Bioprospecting 2023年第1期13卷 206-213页

作者： Jing Fan Pai Liu Kuan Zhao He-Ping Chen School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China School of Pharmacy Anhui University of Chinese MedicineHefei 230012China College of Life Science Jiangxi Science&Technology Normal UniversityNanchang 330013China

Three previously undescribed compounds,cordycicadione(1),cordycicadin F(2),and 7-hydroxybassiatin(3),were isolated from the cultures of Cordyceps cicadae JXCH1,an entomopathogenic *** structures and relative configurations were elucidated primarily by NMR spectroscopic *** absolute configurations of 1 and 2 were determined by ECD ***-crystal X-ray diffraction method was adopted to determine the absolute configuration of *** 2 is a polycyclic polyketide with an unusual enol ether moiety and a spiro *** compounds obtained in this study were subjected to screening their inhibition against the proliferation of the human lung cancer cell line A549 and the production of nitric oxide in murine macrophages RAW264.7.

关键词： Insect pathogenic fungus Cordyceps cicadae Steroid Polyketide cyclic dipeptide

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